New Limits on the Polarized Anisotropy of the Cosmic Microwave Background at Subdegree Angular Scales

We update the limit from the 90 GHz PIQUE ground-based polarimeter on the magnitude of any polarized anisotropy of the cosmic microwave radiation. With a second year of data, we have now limited both Q and U on a ring of 1 degree radius. The window functions are broad: for E-mode polarization, the effective l is = 191 +143 -132. We find that the E-mode signal can be no greater than 8.4 microK (95% CL), assuming no B-mode polarization. Limits on a possible B-mode signal are also presented.Comment: 4 pages, 3 figures, submitted to Astrophysical Journal Letter

Titan's atmosphere as observed by Cassini/VIMS solar occultations: CH4_4, CO and evidence for C2_2H6_6 absorption

We present an analysis of the VIMS solar occultations dataset, which allows us to extract vertically resolved information on the characteristics of Titan's atmosphere between 100-700 km with a characteristic vertical resolution of 10 km. After a series of data treatment procedures, 4 occultations out of 10 are retained. This sample covers different seasons and latitudes of Titan. The transmittances show clearly the evolution of the haze and detect the detached layer at 310 km in Sept. 2011 at mid-northern latitudes. Through the inversion of the transmission spectra with a line-by-line radiative transfer code we retrieve the vertical distribution of CH$_4$ and CO mixing ratio. The two methane bands at 1.4 and 1.7 {\mu}m are always in good agreement and yield an average stratospheric abundance of $1.28\pm0.08$%. This is significantly less than the value of 1.48% obtained by the GCMS/Huygens instrument. The analysis of the residual spectra after the inversion shows that there are additional absorptions which affect a great part of the VIMS wavelength range. We attribute many of these additional bands to gaseous ethane, whose near-infrared spectrum is not well modeled yet. Ethane contributes significantly to the strong absorption between 3.2-3.5 {\mu}m that was previously attributed only to C-H stretching bands from aerosols. Ethane bands may affect the surface windows too, especially at 2.7 {\mu}m. Other residual bands are generated by stretching modes of C-H, C-C and C-N bonds. In addition to the C-H stretch from aliphatic hydrocarbons at 3.4 {\mu}m, we detect a strong and narrow absorption at 3.28 {\mu}m which we tentatively attribute to the presence of PAHs in the stratosphere. C-C and C-N stretching bands are possibly present between 4.3-4.5 {\mu}m. Finally, we obtain the CO mixing ratio between 70-170 km. The average result of $46\pm16$ ppm is in good agreement with previous studies.Comment: 51 pages, 28 figure

Image-Based Scene Representations for Head-Motion Parallax in 360° Panoramas

Creation and delivery of “RealVR” experiences essentially consists of the following four main steps: capture, processing, representation and rendering. In this chapter, we present, compare, and discuss two recent end-to-end approaches, Parallax360 by Luo et al. [9] and MegaParallax by Bertel et al. [3]. Both propose complete pipelines for RealVR content generation and novel-view synthesis with head-motion parallax for 360° environments.Parallax360 uses a robotic arm for capturing thousands of input views on the surface of a sphere. Based on precomputed disparity motion fields and pairwise optical flow, novel viewpoints are synthesized on the fly using flow-based blending of the nearest two to three input views which provides compelling head-motion parallax.MegaParallax proposes a pipeline for RealVR content generation and rendering that emphasizes casual, hand-held capturing. The approach introduces view-dependent flow-based blending to enable novel-view synthesis with head-motion parallax within a viewing area determined by the field of view of the input cameras and the capturing radius.We describe both methods and discuss their similarities and differences in corresponding steps in the RealVR pipeline and show selected results. The chapter ends by discussing advantages and disadvantages as well as outlining the most important limitations and future work.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 66599

Calmodulin Lobes Facilitate Dimerization and Activation of Estrogen Receptor-Alpha

Estrogen receptor α (ER-α) is a nuclear hormone receptor that controls selected genes, thereby regulating proliferation and differentiation of target tissues, such as breast. Gene expression controlled by ER-α is modulated by Ca2+ via calmodulin (CaM). Here we present the NMR structure of Ca2+-CaM bound to two molecules of ER-α (residues 287–305). The two lobes of CaM bind to the same site on two separate ER-α molecules (residues 292, 296, 299, 302, and 303), which explains why CaM binds two molecules of ER-α in a 1:2 complex and stabilizes ER-α dimerization. Exposed glutamate residues in CaM (Glu-11, Glu-14, Glu-84, and Glu-87) form salt bridges with key lysine residues in ER-α (Lys-299, Lys-302, and Lys-303), which is likely to prevent ubiquitination at these sites and inhibit degradation of ER-α. Transfection of cells with full-length CaM slightly increased the ability of estrogen to enhance transcriptional activation by ER-α of endogenous estrogen-responsive genes. By contrast, expression of either the N- or C-lobe of CaM abrogated estrogen-stimulated transcription of the estrogen responsive genes pS2 and progesterone receptor. These data suggest that CaM-induced dimerization of ER-α is required for estrogen-stimulated transcriptional activation by the receptor. In light of the critical role of ER-α in breast carcinoma, our data suggest that small molecules that selectively disrupt the interaction of ER-α with CaM may be useful in the therapy of breast carcinoma

A Limit on the Polarized Anisotropy of the Cosmic Microwave Background at Subdegree Angular Scales

A ground-based polarimeter, PIQUE, operating at 90 GHz has set a new limit on the magnitude of any polarized anisotropy in the cosmic microwave background. The combination of the scan strategy and full width half maximum beam of 0.235 degrees gives broad window functions with average multipoles, l = 211+294-146 and l = 212+229-135 for the E- and B-mode window functions, respectively. A joint likelihood analysis yields simultaneous 95% confidence level flat band power limits of 14 and 13 microkelvin on the amplitudes of the E- and B-mode angular power spectra, respectively. Assuming no B-modes, a 95% confidence limit of 10 microkelvin is placed on the amplitude of the E-mode angular power spectrum alone.Comment: 4 pages, 3 figures, submitted to Astrophysical Journal Letter

In-situ measurement of electrodermal activity during occupational therapy

Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 59-61).Physiological arousal is an important part of occupational therapy for children with Sensory Processing Disorder (SPD) but therapists do not have a way to objectively measure how therapy affects arousal. We hypothesized that when children with SPD participate in guided activities within an occupational therapy setting, informative changes in electrodermal activity (EDA) can be detected using iCalm. iCalm is a small, wireless sensor developed at MIT that measures EDA and motion, worn on the wrist or above the ankle. Twenty-two children (ages 3-10) with a clinical diagnosis of SPD participated. EDA was measured from the backs of the children's ankles. Concurrent video recordings allowed for comparison of therapeutic activities and children's EDA. Overall, we measured 77 therapy sessions. All measurements were in-situ, during regularly scheduled therapy sessions. Statistical analysis describing how equipment affects EDA was inconclusive, suggesting that many factors play a role in how a child's EDA changes. Case studies provided examples of how occupational therapy affected children's EDA. This is the first study of the effects of occupational therapy's in-situ activities using continuous physiologic measures. The results suggest that careful case-study analyses of the relation between therapeutic activities and physiological arousal may inform clinical practice.by Elliott B. Hedman.S.M