The Dying Miner

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Enhancing Teacher Credibility: What We Can Learn From the Justice and Leadership Literature

Enhanced perceptions of instructor credibility are related to positive outcomes in the classroom, including participation and learning (Chory, 2007; Frymier & Thompson, 1992; McCroskey & Teven, 1999; Myers, 2004; Teven & McCroskey, 1997). We contend that student perceptions of instructor credibility can be directly impacted by applying management research to classroom practices. In other words, actionable management research is useful in the classroom not just to share with students because it may make them better managers, but also to improve teaching practices and related outcomes. The present article explores this tenet, first discussing why we believe applied research findings can and should be transferred to the classroom and then using Implicit Leadership Theory (ILT) and organizational justice literature to demonstrate how these concepts can be generalized to the classroom environment to ultimately enhance instructor credibility

Penetration of fusidic acid and rifampicin into cerebrospinal fluid in low-grade inflammatory meningitis caused by Staphylococcus epidermidis

AbstractCerebrospinal fluid (CSF) concentration-time curves of rifampicin and fusidic acid were studied in a patient with post-operative meningitis caused by Staphylococcus epidermidis. The patient was treated with this combination of antimicrobial agents because of a severe hypersensitivity reaction to vancomycin. Peak CSF concentrations of rifampicin exceeded the MIC by > 60-fold, while those of fusidic acid just reached the MIC. CSF concentrations of fusidic acid were relatively stable within the range reported for patients with uninflamed meninges, but serum levels were surprisingly low. An increase in the metabolism of fusidic acid induced by rifampicin cannot be excluded

An electromagnetic shashlik calorimeter with longitudinal segmentation

A novel technique for longitudinal segmentation of shashlik calorimeters has been tested in the CERN West Area beam facility. A 25 tower very fine samplings e.m. calorimeter has been built with vacuum photodiodes inserted in the first 8 radiation lengths to sample the initial development of the shower. Results concerning energy resolution, impact point reconstruction and electron/pion separation are reported.Comment: 13 pages, 12 figure

The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo

Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical renal cell carcinoma (RCC) models. Caki-1, KTC-26 or A498 cells were treated with various concentrations of VPA during in vitro cell proliferation 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays and to evaluate cell cycle manipulation. In vivo tumour growth was conducted in subcutaneous xenograft mouse models. The anti-tumoural potential of VPA combined with low-dosed interferon-α (IFN-α) was also investigated. VPA significantly and dose-dependently up-regulated histones H3 and H4 acetylation and caused growth arrest in RCC cells. VPA altered cell cycle regulating proteins, in particular CDK2, cyclin B, cyclin D3, p21 and Rb. In vivo, VPA significantly inhibited the growth of Caki-1 in subcutaneous xenografts, accompanied by a strong accumulation of p21 and bax in tissue specimens of VPA-treated animals. VPA–IFN-α combination markedly enhanced the effects of VPA monotherapy on RCC proliferation in vitro, but did not further enhance the anti-tumoural potential of VPA in vivo. VPA was found to have profound effects on RCC cell growth, lending support to the initiation of clinical testing of VPA for treating advanced RCC

Loading and unloading of sedimentary basins: the effect of rheological hysteresis

We present a model for the study of the effect of rheological hysteresis on compaction in sedimentary basins, when surface loading and unloading occurs. When compaction is slow (sedimentation rate is large and/or permeability is small), the hysteresis has little effect on the basal compaction layer, but in the more realistic case where compaction is fast (i.e., sedimentation is slow and/or permeability is large), surface unloading leads to downward propagation of a decompaction front, across which the vertical porosity gradient jumps, while subsequent surface reloading leads to downward propagation of a discontinuity in porosity, despite the fact that the porosity is governed by a diffusive equation of Richards type

Project status of the CMS tracker optical links

The development phase of the optical data transfer system for the CMS tracker is now complete. This paper presents the project status and reviews the preparation for production. In particular, it focuses on the results of the market surveys for front-end components, and on the performance evaluation of a close-to-final readout chain. I