316 research outputs found
Разработка способа очистки газовой среды в процессе выращивания полупроводниковых монокристаллов
An individual’s zinc status has a significant impact on the immune system, and zinc deficiency, as well as supplementation, modulates immune function. To investigate the effects of zinc on different leukocyte subsets, we used microarray technology to analyze and compare the changes in mRNA expression in cell culture models of monocytes (THP-1), T cells (Jurkat), and B cells (Raji), in response to supplementation for 40 h with 50 μM zinc or 2.5 μM of the membrane-permeant zinc chelator TPEN [N,N,N′,N′-tetrakis-(2-pyridyl-methyl)ethylenediamine], respectively. In each cell type, several hundred genes were identified to be zinc sensitive, but only a total of seven genes were commonly regulated in all three cell lines. The majority of those genes were involved in zinc homeostasis, and none in immune function. Nevertheless, further analysis revealed that zinc affects entire functional networks of genes that are related to proinflammatory cytokines and cellular survival. Although the zinc-regulated activities are similar throughout the gene networks, the specific genes that are affected vary significantly between different cell types, a situation that helps to elucidate the disparity of the effects that zinc has on different leukocyte populations
Environmental assessment of the Urban Mining and Recycling (UMAR) unit by applying the LCA framework
Magnetic and superconducting properties of Cd2Re2O7: Cd NMR and Re NQR
We report Cd NMR and Re NQR studies on Cd2Re2O7, the first superconductor
among pyrochlore oxides Tc=1 K. Re NQR spectrum at zero magnetic field below
100 K rules out any magnetic or charge order. The spin-lattice relaxation rate
below Tc exhibits a pronounced coherence peak and behaves within the
weak-coupling BCS theory with nearly isotropic energy gap. Cd NMR results point
to moderate ferromagnetic enhancement at high temperatures followed by rapid
decrease of the density of states below the structural transition temperature
of 200 K.Comment: 4 pages, 4 figure
A spheroid toxicity assay using magnetic 3D bioprinting and real-time mobile device-based imaging
An ongoing challenge in biomedical research is the search for simple, yet robust assays using 3D cell cultures for toxicity screening. This study addresses that challenge with a novel spheroid assay, wherein spheroids, formed by magnetic 3D bioprinting, contract immediately as cells rearrange and compact the spheroid in relation to viability and cytoskeletal organization. Thus, spheroid size can be used as a simple metric for toxicity. The goal of this study was to validate spheroid contraction as a cytotoxic endpoint using 3T3 fibroblasts in response to 5 toxic compounds (all-trans retinoic acid, dexamethasone, doxorubicin, 5′-fluorouracil, forskolin), sodium dodecyl sulfate (+control), and penicillin-G (−control). Real-time imaging was performed with a mobile device to increase throughput and efficiency. All compounds but penicillin-G significantly slowed contraction in a dose-dependent manner (Z’ = 0.88). Cells in 3D were more resistant to toxicity than cells in 2D, whose toxicity was measured by the MTT assay. Fluorescent staining and gene expression profiling of spheroids confirmed these findings. The results of this study validate spheroid contraction within this assay as an easy, biologically relevant endpoint for high-throughput compound screening in representative 3D environments
New magnetic coherence effect in superconducting La_{2-x}Sr_{x}CuO_{4}
We have used inelastic neutron scattering to examine the magnetic
fluctuations at intermediate frequencies in the simplest high temperature
superconductor, La_{2-x}Sr_{x}Cu_{4}. The suppression of the low energy
magnetic response in the superconducting state is accompanied by an increase in
the response at higher energies. Just above a threshold energy of ~7 meV there
is additional scattering present below T_{c} which is characterised by an
extraordinarily long coherence length, in excess of 50 \AA.Comment: 11 pages, RevTeX, 4 postscript figure
A topological Dirac insulator in a quantum spin Hall phase : Experimental observation of first strong topological insulator
When electrons are subject to a large external magnetic field, the
conventional charge quantum Hall effect \cite{Klitzing,Tsui} dictates that an
electronic excitation gap is generated in the sample bulk, but metallic
conduction is permitted at the boundary. Recent theoretical models suggest that
certain bulk insulators with large spin-orbit interactions may also naturally
support conducting topological boundary states in the extreme quantum limit,
which opens up the possibility for studying unusual quantum Hall-like phenomena
in zero external magnetic field. Bulk BiSb single crystals are
expected to be prime candidates for one such unusual Hall phase of matter known
as the topological insulator. The hallmark of a topological insulator is the
existence of metallic surface states that are higher dimensional analogues of
the edge states that characterize a spin Hall insulator. In addition to its
interesting boundary states, the bulk of BiSb is predicted to
exhibit three-dimensional Dirac particles, another topic of heightened current
interest. Here, using incident-photon-energy-modulated (IPEM-ARPES), we report
the first direct observation of massive Dirac particles in the bulk of
BiSb, locate the Kramers' points at the sample's boundary and
provide a comprehensive mapping of the topological Dirac insulator's gapless
surface modes. These findings taken together suggest that the observed surface
state on the boundary of the bulk insulator is a realization of the much sought
exotic "topological metal". They also suggest that this material has potential
application in developing next-generation quantum computing devices.Comment: 16 pages, 3 Figures. Submitted to NATURE on 25th November(2007
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