7 research outputs found
Counts-in-Cylinders in the Sloan Digital Sky Survey with Comparisons to N-body Simulations
Environmental statistics provide a necessary means of comparing the
properties of galaxies in different environments and a vital test of models of
galaxy formation within the prevailing, hierarchical cosmological model. We
explore counts-in-cylinders, a common statistic defined as the number of
companions of a particular galaxy found within a given projected radius and
redshift interval. Galaxy distributions with the same two-point correlation
functions do not necessarily have the same companion count distributions. We
use this statistic to examine the environments of galaxies in the Sloan Digital
Sky Survey, Data Release 4. We also make preliminary comparisons to four models
for the spatial distributions of galaxies, based on N-body simulations, and
data from SDSS DR4 to study the utility of the counts-in-cylinders statistic.
There is a very large scatter between the number of companions a galaxy has and
the mass of its parent dark matter halo and the halo occupation, limiting the
utility of this statistic for certain kinds of environmental studies. We also
show that prevalent, empirical models of galaxy clustering that match observed
two- and three-point clustering statistics well fail to reproduce some aspects
of the observed distribution of counts-in-cylinders on 1, 3 and 6-Mpc/h scales.
All models that we explore underpredict the fraction of galaxies with few or no
companions in 3 and 6-Mpc/h cylinders. Roughly 7% of galaxies in the real
universe are significantly more isolated within a 6 Mpc/h cylinder than the
galaxies in any of the models we use. Simple, phenomenological models that map
galaxies to dark matter halos fail to reproduce high-order clustering
statistics in low-density environments.Comment: 17 pages, 10 figures. Accepted, Ap
Close Galaxy Counts as a Probe of Hierarchical Structure Formation
Standard LCDM predicts that the major merger rate of galaxy-size dark matter
halos rises rapidly with redshift. The average number of close companions per
galaxy, Nc, is often used to infer the galaxy merger rate, however, recent
observational studies suggest that Nc evolves very little with redshift. Here
we use a "hybrid" N- body simulation plus analytic substructure model to
predict Nc directly. We identify dark matter subhalos with galaxies and show
that the observed lack of close pair count evolution arises because the high
merger rate per halo at early times is counteracted by a decrease in the number
of halos massive enough to host a galaxy pair. We compare our results to data
compiled from the DEEP2, SSRS2, and the UZC redshift surveys. Observed pair
counts match our predictions if we assume a monotonic mapping between galaxy
luminosity and the maximum circular velocity that each subhalo had when it was
first accreted onto its host halo. This suggests that satellite galaxies are
significantly more resilient to destruction than are dissipationless dark
matter subhalos. We argue that while Nc does not provide a direct measure of
the halo merger rate, it offers a powerful means to constrain the Halo
Occupation Distribution and the spatial distribution of galaxies within halos.
Interpreted in this way, close pair counts provide a useful test of galaxy
formation processes on < 100 kpc scales.Comment: 16 pages, 16 figures, minor change to figure 10, figure captions
updated, typos corrected, Figure 4 corrected, version accepted for
publication by Ap
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Counts-in-Cylinders in the Sloan Digital Sky Survey with Comparisons to N-Body
Environmental statistics provide a necessary means of comparing the properties of galaxies in different environments and a vital test of models of galaxy formation within the prevailing, hierarchical cosmological model. We explore counts-in-cylinders, a common statistic defined as the number of companions of a particular galaxy found within a given projected radius and redshift interval. Galaxy distributions with the same two-point correlation functions do not necessarily have the same companion count distributions. We use this statistic to examine the environments of galaxies in the Sloan Digital Sky Survey, Data Release 4. We also make preliminary comparisons to four models for the spatial distributions of galaxies, based on N-body simulations, and data from SDSS DR4 to study the utility of the counts-in-cylinders statistic. There is a very large scatter between the number of companions a galaxy has and the mass of its parent dark matter halo and the halo occupation, limiting the utility of this statistic for certain kinds of environmental studies. We also show that prevalent, empirical models of galaxy clustering that match observed two- and three-point clustering statistics well fail to reproduce some aspects of the observed distribution of counts-in-cylinders on 1, 3 and 6-h{sup -1}Mpc scales. All models that we explore underpredict the fraction of galaxies with few or no companions in 3 and 6-h{sup -1} Mpc cylinders. Roughly 7% of galaxies in the real universe are significantly more isolated within a 6 h{sup -1} Mpc cylinder than the galaxies in any of the models we use. Simple, phenomenological models that map galaxies to dark matter halos fail to reproduce high-order clustering statistics in low-density environments
Exposure Route Influences Disease Severity in the COVID-19 Cynomolgus Macaque Model
The emergence of SARS-CoV-2 and the subsequent pandemic has highlighted the need for animal models that faithfully replicate the salient features of COVID-19 disease in humans. These models are necessary for the rapid selection, testing, and evaluation of potential medical countermeasures. Here, we performed a direct comparison of two distinct routes of SARS-CoV-2 exposure—combined intratracheal/intranasal and small particle aerosol—in two nonhuman primate species, rhesus and cynomolgus macaques. While all four experimental groups displayed very few outward clinical signs, evidence of mild to moderate respiratory disease was present on radiographs and at necropsy. Cynomolgus macaques exposed via the aerosol route also developed the most consistent fever responses and had the most severe respiratory disease and pathology. This study demonstrates that while all four models produced suitable representations of mild COVID-like illness, aerosol exposure of cynomolgus macaques to SARS-CoV-2 produced the most severe disease, which may provide additional clinical endpoints for evaluating therapeutics and vaccines
Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure.
Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to determine critical disease parameters associated with disease progression, and establish correlations between primate and human COVID-19. Respiratory abnormalities and viral shedding were noted for all animals, indicating successful infection. Cynomolgus macaques developed fever, and thrombocytopenia was measured for African green monkeys and rhesus macaques. Type II pneumocyte hyperplasia and alveolar fibrosis were more frequently observed in lung tissue from cynomolgus macaques and African green monkeys. The data indicate that, in addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation