IC 044 Gude to National Heart and Blood Vessel Research and Demonstration Center Records, 1975-1983

The National Heart and Blood Vessel Research & Demonstration Center records contains a directory, bulletins, reports, and other various printed material related to the National Heart and Blood Vessel Research & Demonstration Center. See more at https://archives.library.tmc.edu/ic-044

Modified Bentall operation with bioprosthetic valve and Valsalva graft conduit:the "slit skirt" technique

We elucidated the efficacy of the slit skirt technique to prevent bleeding from the proximal anastomosis between the graft and aortic annulus. Between September 2008 and September 2014, 15 patients underwent a modified Bentall operation with the slit skirt technique at our institution. No patients had bleeding from the proximal anastomosis. No re-thoracotomy for bleeding was required. During midterm follow-up (median period, 21 months), no patient had pseudoaneurysms at the proximal suture line. We conclude that the slit skirt technique is useful to prevent bleeding from the proximal anastomosis after the Bentall operation

Toas Walkability Workshop

The Taos Land Trust, University of New Mexico’s Prevention Research Center, Strong at Heart, and members of the Taos community worked together to assess how safe and easy it is for people to get around Taos on foot. Walkable communities are healthier, safer, cleaner, and more economical. More than thirty people discussed their experiences walking in Taos, built awareness of particular problem areas, and generated ideas to make the downtown area more pedestrian friendly

NO formation in nucleus tractus solitarii attenuates pressor response evoked by skeletal muscle afferents

Li, Jianhua, and Jeffrey T. Potts. NO formation in nucleus tractus solitarii attenuates pressor response evoked by skeletal muscle afferents. Am J Physiol Heart Circ Physiol 280: H2371-H2379, 2001.-We have previously shown that static muscle contraction induces the expression of c-Fos protein in neurons of the nucleus tractus solitarii (NTS) and that some of these cells were codistributed with neuronal NADPH-diaphorase [nitric oxide (NO) synthase]-positive fibers. In the present study, we sought to determine the role of NO in the NTS in mediating the cardiovascular responses elicited by skeletal muscle afferent fibers. Static contraction of the triceps surae muscle was induced by electrical stimulation of the L7 and S1 ventral roots in anesthetized cats. Muscle contraction during microdialysis of artificial extracellular fluid increased mean arterial pressure (MAP) and heart rate (HR) 51 Ϯ 9 mmHg and 18 Ϯ 3 beats/min, respectively. Microdialysis of L-arginine (10 mM) into the NTS to locally increase NO formation attenuated the increases in MAP (30 Ϯ 7 mmHg, P Ͻ 0.05) and HR (14 Ϯ 2 beats/min, P Ͼ 0.05) during contraction. Microdialysis of D-arginine (10 mM) did not alter the cardiovascular responses evoked by muscle contraction. Microdialysis of N G -nitro-L-arginine methyl ester (2 mM) during contraction attenuated the effects of Larginine on the reflex cardiovascular responses. These findings demonstrate that an increase in NO formation in the NTS attenuates the pressor response to static muscle contraction, indicating that the NO system plays a role in mediating the cardiovascular responses to static muscle contraction in the NTS. cardiovascular responses; static muscle contraction; blood pressure; heart rate; microdialysis; L-arginine; L-NAME STUDIES HAVE DEMONSTRATED that nitric oxide (NO) synthase (NOS) is localized in discrete medullary areas (41) involved in cardiovascular regulation The evidence that the muscle afferents terminate in several laminae of the spinal cord as well as ascending to terminate in the NTS has been shown by neuroanatomic tracing studies MATERIALS AND METHODS General Surgical Preparation Experiments were performed on 25 anesthetized cats of either sex weighing 3.4-5.5 kg. The animals were anesthetized by inhalation of a halothane-oxygen mixture (2-3%). An endotracheal tube was inserted into the trachea via a tracheotomy to maintain an open airway, and the jugular vein and carotid artery were catheterized for drug administration and measurement of ABP, respectively. Anesthesia was then maintained with a mixture of ␣-chloralose (80 mg/kg) and urethane (200 mg/kg) injected intravenously. Throughout the experiment, supplemental ␣-chloralose (15 mg/kg iv) was given if the cats exhibited a corneal reflex or if they withdrew a limb in response to a noxious stimulus

Out-of-hospital cardiac arrest surveillance: Cardiac Arrest Registry to Enhance Survival (CARES), United States, October 1, 2005-December 31, 2010

PROBLEM/CONDITION: Each year, approximately 300,000 persons in the United States experience an out-of-hospital cardiac arrest (OHCA); approximately 92% of persons who experience an OHCA event die. An OHCA is defined as cessation of cardiac mechanical activity that occurs outside of the hospital setting and is confirmed by the absence of signs of circulation. Whereas an OHCA can occur from noncardiac causes (i.e., trauma, drowning, overdose, asphyxia, electrocution, primary respiratory arrests, and other noncardiac etiologies), the majority (70%--85%) of such events have a cardiac cause. The majority of persons who experience an OHCA event, irrespective of etiology, do not receive bystander-assisted cardiopulmonary resuscitation (CPR) or other timely interventions that are known to improve the likelihood of survival to hospital discharge (e.g., defibrillation). Because nearly half of cardiac arrest events are witnessed, efforts to increase survival rates should focus on timely and effective delivery of interventions by bystanders and emergency medical services (EMS) personnel. This is the first report to provide summary data from an OHCA surveillance registry in the United States. REPORTING PERIOD: This report summarizes surveillance data collected during October 1, 2005-- December 31, 2010. DESCRIPTION OF THE SYSTEM: In 2004, CDC established the Cardiac Arrest Registry to Enhance Survival (CARES) in collaboration with the Department of Emergency Medicine at the Emory University School of Medicine. This registry evaluates only OHCA events of presumed cardiac etiology that involve persons who received resuscitative efforts, including CPR or defibrillation. Participating sites collect data from three sources that define the continuum of emergency cardiac care: 911 dispatch centers, EMS providers, and receiving hospitals. OHCA is defined in CARES as a cardiac arrest that occurred in the prehospital setting, had a presumed cardiac etiology, and involved a person who received resuscitative efforts, including CPR or defibrillation. RESULTS: During October 1, 2005--December 31, 2010, a total of 40,274 OHCA records were submitted to the CARES registry. After noncardiac etiology arrests and missing hospital outcomes were excluded from the analysis (n = 8,585), 31,689 OHCA events of presumed cardiac etiology (e.g., myocardial infarction or arrhythmia) that received resuscitation efforts in the prehospital setting were analyzed. The mean age at cardiac arrest was 64.0 years (standard deviation [SD]: 18.2); 61.1% of persons who experienced OHCA were male (n = 19,360). According to local EMS agency protocols, 21.6% of patients were pronounced dead after resuscitation efforts were terminated in the prehospital setting. The survival rate to hospital admission was 26.3%, and the overall survival rate to hospital discharge was 9.6%. Approximately 36.7% of OHCA events were witnessed by a bystander. Only 33.3% of all patients received bystander CPR, and only 3.7% were treated by bystanders with an automated external defibrillator (AED) before the arrival of EMS providers. The group most likely to survive an OHCA are persons who are witnessed to collapse by a bystander and found in a shockable rhythm (e.g., ventricular fibrillation or pulseless ventricular tachycardia). Among this group, survival to discharge was 30.1%. A subgroup analysis was performed among persons who experienced OHCA events that were not witnessed by EMS personnel to evaluate rates of bystander CPR for these persons. After exclusion of 3,400 OHCA events that occurred after the arrival of EMS providers, bystander CPR information was analyzed for 28,289 events. In this group, whites were significantly more likely to receive CPR than blacks, Hispanics, or members of other racial/ethnic populations (p<0.001). Overall survival to hospital discharge of patients whose events were not witnessed by EMS personnel was 8.5%. Of these, patients who received bystander CPR had a significantly higher rate of overall survival (11.2%) than those who did not (7.0%) (p<0.001). INTERPRETATION: CARES data have helped identify opportunities for improvement in OHCA care. The registry is being used continually to monitor prehospital performance and selected aspects of hospital care to improve quality of care and increase rates of survival following OHCA. CARES data confirm that patients who receive CPR from bystanders have a greater chance of surviving OHCA than those who do not. PUBLIC HEALTH ACTIONS: Medical directors and public health professionals in participating communities use CARES data to measure and improve the quality of prehospital care for persons experiencing OHCA. Tracking performance longitudinally allows communities to better understand which elements of their care are working well and which elements need improvement. Education of public officials and community members about the importance of increasing rates of bystander CPR and promoting the use of early defibrillation by lay and professional rescuers is critical to increasing survival rates. Reporting at the state and local levels can enable state and local public health and EMS agencies to coordinate their efforts to target improving emergency response for OHCA events, regardless of etiology, which can lead to improvement in OHCA survival rates.Bryan McNally, Rachel Robb, Monica Mehta, Kimberly Vellano, Amy L. Valderrama, Paula W. Yoon, Comilla Sasson, Allison Crouch, Amanda Bray Perez, Robert Merritt, Arthur Kellermann.Cover title."Corresponding author: Amy L. Valderrama, [Division for Heart Disease and Stroke Prevention,] National Center for Chronic Disease Prevention and Health Promotion, CDC"--P. 1."July 29, 2011.""U.S. Government Printing Office: 2011-723-011/21060, Region IV"--P. [4] of cover.Also available via the World Wide Web.Includes bibliographical references (p. 19)

Worksite health

The CDC Worksite Health ScoreCard (HSC) is a tool designed to help employers assess whether they have implemented evidence-based health promotion interventions or strategies in their worksites to prevent heart disease, stroke, and related conditions such as hypertension, diabetes, and obesity. The tool was developed by the CDC Division for Heart Disease and Stroke Prevention in collaboration with the Emory University Institute for Health and Productivity Studies (IHPS), the Research Triangle Institute, the CDC National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP) Workplace Workgroup, and an expert panel of federal, state, academic, and private sector. To ensure the validity and reliability of the tool, a validation study was conducted by Emory University's IHPS. This study involved a national sample of 93 employers of variable size who agreed to pilot test the survey and provide feedback on the survey's content and structure.Acknowledgements and suggested citation -- Introduction -- Using the Health ScoreCard (HSC) -- Instructions -- Scoring your survey -- CDC worksite health ScoreCard worksheet -- Validation study benchmarking report -- References -- Appendix A. Frequently asked questions (FAQs) -- Appendix B. Resources for action -- Appendix C. Glossary -- Appendix D. Scoring methodology -- Appendix E. Worksite plan and budget templatesDyann M. Matson-Koffman, Lead Scientific Advisor.On cover: Health scorecard manual."CS234218."Available via the World Wide Web as an Acrobat .pdf file (1.77 MB, 72 p.).Centers for Disease Control and Prevention. The CDC Worksite Health ScoreCard: An Assessment Tool for Employers to Prevent Heart Disease, Stroke, and Related Health Conditions. Atlanta: U.S. Department of Health and Human Services; 2012

Addressing chronic disease through community health workers: a policy and systems-level approach : a policy brief on community health workers

This document provides guidance and resources for implementing recommendations to integrate community health workers (CHWs) into community-based efforts to prevent chronic disease. After providing general information on CHWs in the United States, it sets forth evidence demonstrating the value and impact of CHWs in preventing and managing a variety of chronic diseases, including heart disease and stroke, diabetes, and cancer. In addition, descriptions are offered of chronic disease programs that are engaging CHWs, examples of state legislative action are provided, recommendations are made for comprehensive polices to build capacity for an integrated and sustainable CHW workforce in the public health arena, and resources are described that can assist state health departments and others in making progress with CHWs."9/27/11." - date from document propertiesIncludes bibliographical refernces (p. 13-16)

Sodium reduction in communities

"Reducing sodium intake is a priority for the Centers for Disease Control and Prevention (CDC), which is working to reduce sodium intake by promoting local, state, and national strategies; working with public and private stakeholders; enhancing the monitoring of sodium intake and changes in the food supply; and expanding scientific literature on sodium. In 2010, CDC launched the Sodium Reduction in Communities Program (SRCP) to reduce sodium intake by helping create healthier food environments at the local level. Five sites were funded to promote and sustain policy, system, and environ-mental changes in communities and to conduct program evaluations of their progress toward reducing sodium consumption in the population." - p. 1Date from document properties.Also available via the World Wide Web as an Acrobat .pdf file (266 KB, 2 p.)