22 research outputs found
Comparison of hemodynamic changes between phenylephrine and combined phenylephrine and glycopyrrolate groups after spinal anesthesia for cesarean delivery
Prophylactic antiemetic effects in gynecologic patients receiving fentanyl IV-patient controlled analgesia: comparison of combined treatment with ondansetron and dexamethasone with metoclopramide and dexamethasone
The Effects of Preoperative Information and Hand Massage on Postoperative Satisfaction Score after Cesarean Section under Combind Spinal-Epidural Anesthesia
Correlations between Mean Arterial Blood Pressure, Cardiac Index, and Systemic Vascular Resistance Index in Laparoscopically-assisted Vaginal Hysterectomy (LAVH)
Hemodynamic Effects of Intravenous Bolus Dosing of Nicardipine on Pneumoperitoneum during Laparoscopically-Assisted Vaginal Hysterectomy (LAVH)
Effects of a Crystalloid Preload on Hemodynamics after Pneumoperitoneum in Laparoscopically-Assisted Vaginal Hysterectomy (LAVH)
A Comparison of Analgesic Effects and Side Effects of Intrathecal Morphine, Nalbuphine and a Morphine-Nalbuphine Mixture for Pain Relief during a Cesarean Section
Effect of Saline-Filled or Viscous Lidocaine-Filled Cuff on the Laser-Induced Polyvinyl Chloride Endotracheal Tube Fires and Tidal Volume
Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model.
The primary cilium is an organelle protruding from the cell body that senses external stimuli including chemical, mechanical, light, osmotic, fluid flow, and gravitational signals. Skin is always exposed to the external environment and responds to external stimuli. Therefore, it is possible that primary cilia have an important role in skin. Ciliogenesis was reported to be involved in developmental processes in skin, such as keratinocyte differentiation and hair formation. However, the relation between skin pigmentation and primary cilia is largely unknown. Here, we observed that increased melanogenesis in melanocytes treated with a melanogenic inducer was inhibited by a ciliogenesis inducer, cytochalasin D, and serum-free culture. However, these inhibitory effects disappeared in GLI2 knockdown cells. In addition, activation of sonic hedgehog (SHH)-smoothened (Smo) signaling pathway by a Smo agonist, SAG inhibited melanin synthesis in melanocytes and pigmentation in a human skin model. On the contrary, an inhibitor of primary cilium formation, ciliobrevin A1, activated melanogenesis in melanocytes. These results suggest that skin pigmentation may be regulated partly by the induction of ciliogenesis through Smo-GLI2 signaling