15 research outputs found
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Generalized alternating direction method of multipliers: new theoretical insights and applications
© 2015, Springer-Verlag Berlin Heidelberg and The Mathematical Programming Society. Recently, the alternating direction method of multipliers (ADMM) has received intensive attention from a broad spectrum of areas. The generalized ADMM (GADMM) proposed by Eckstein and Bertsekas is an efficient and simple acceleration scheme of ADMM. In this paper, we take a deeper look at the linearized version of GADMM where one of its subproblems is approximated by a linearization strategy. This linearized version is particularly efficient for a number of applications arising from different areas. Theoretically, we show the worst-case O(1/k) convergence rate measured by the iteration complexity (k represents the iteration counter) in both the ergodic and a nonergodic senses for the linearized version of GADMM. Numerically, we demonstrate the efficiency of this linearized version of GADMM by some rather new and core applications in statistical learning. Code packages in Matlab for these applications are also developed.Link_to_subscribed_fulltex
Effects of brominated flame retardants and brominated dioxins on steroidogenesis in H295R human adrenocortical carcinoma cell line
Brominated flame retardants (BFRs) and brominated dioxins are emerging persistent organic pollutants that are ubiquitous in the environment and can be accumulated by wildlife and humans. These chemicals can disturb endocrine function. Recent studies have demonstrated that one of the mechanisms of endocrine disruption by chemicals is modulation of steroidogenic gene expression or enzyme activities. In this study, an in vitro assay based on the H295R human adrenocortical carcinoma cell line, which possesses most key genes or enzymes involved in steroidogenesis, was used to examine the effects of five bromophenols, two polybrominated biphenyls (PBBs 77 and 169), 2,3,7,8-tetrabromodibenzo-p-dioxin, and 2,3,7,8-tetrabromodibenzofuran on the expression of 10 key steroidogenic genes. The H295R cells were exposed to various BFR concentrations for 48 h, and the expression of specific genes - cytochrome P450 (CYP11A, CYP11B2, CYP17, CYP19, and CYP21), 3β- hydroxysteroid dehydrogenase (3βHSD2), 17β-hydroxysteroid dehydrogenase (17βHSD1 and 17βHSD4), steroidogenic acute regulatory protein (StAR), and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) - was quantitatively measured using real-time polymerase chain reaction. Cell viability was not affected at the doses tested. Most of the genes were either up- or down-regulated, to some extent, by BFR exposure. Among the genes tested, 3βHSD2 was the most markedly up-regulated, with a range of magnitude from 1.6- to 20-fold. The results demonstrate that bromophenol, bromobiphenyls, and bromodibenzo-p-dioxin/furan are able to modulate steroidogenic gene expression, which may lead to endocrine disruption. © 2007 SETAC.link_to_subscribed_fulltex