Modeling oxygen isotopes in the Pliocene: Large-scale features over the land and ocean

The first isotope-enabled general circulation model (GCM) simulations of the Pliocene are used to discuss the interpretation of δ18O measurements for a warm climate. The model suggests that spatial patterns of Pliocene ocean surface δ18O ( inline image) were similar to those of the preindustrial period; however, Arctic and coastal regions were relatively depleted, while South Atlantic and Mediterranean regions were relatively enriched. Modeled inline image anomalies are closely related to modeled salinity anomalies, which supports using inline image as a paleosalinity proxy. Modeled Pliocene precipitation δ18O ( inline image) was enriched relative to the preindustrial values (but with depletion of <2‰ over some tropical regions). While usually modest (<4‰), the enrichment can reach 25‰ over ice sheet regions. In the tropics inline image anomalies are related to precipitation amount anomalies, although there is usually a spatial offset between the two. This offset suggests that the location of precipitation change is more uncertain than the amplitude when interpreting inline image. At high latitudes inline image anomalies relate to temperature anomalies; however, the relationship is neither linear nor spatially coincident: a large inline image signal does not always translate to a large temperature signal. These results suggest that isotope modeling can lead to enhanced synergy between climate models and climate proxy data. The model can relate proxy data to climate in a physically based way even when the relationship is complex and nonlocal. The δ18O-climate relationships, identified here from a GCM, could not be determined from transfer functions or simple models

Sensitivity of Pliocene Arctic climate to orbital forcing, atmospheric CO2 and sea ice albedo parameterisation

General circulation model (GCM) simulations of the mid-Pliocene Warm Period (mPWP, 3.264 to 3.025Myr ago) do not reproduce the magnitude of Northern Hemisphere high latitude surface air and sea surface temperature (SAT and SST) warming that proxy data indicate. There is also large uncertainty regarding the state of sea ice cover in the mPWP. Evidence for both perennial and seasonal mPWP Arctic sea ice is found through analyses of marine sediments, whilst in a multi-model ensemble of mPWP climate simulations, half of the ensemble simulated ice-free summer Arctic conditions. Given the strong influence that sea ice exerts on high latitude temperatures, an understanding of the nature of mPWP Arctic sea ice would be highly beneficial. Using the HadCM3 GCM, this paper explores the impact of various combinations of potential mPWP orbital forcing, atmospheric CO2concentrations and minimum sea ice albedo on sea ice extent and high latitude warming. The focus is on the Northern Hemisphere, due to availability of proxy data, and the large data–model discrepancies in this region. Changes in orbital forcings are demonstrated to be sufficient to alter the Arctic sea ice simulated by HadCM3 from perennial to seasonal. However, this occurs only when atmospheric CO2concentrations exceed 300 ppm. Reduction of the minimum sea ice albedo from 0.5 to 0.2 is also sufficient to simulate seasonal sea ice, with any of the combinations of atmospheric CO2and orbital forcing. Compared to a mPWP control simulation, monthly mean increases north of 60◦N of up to 4.2◦C (SST) and 9.8◦C (SAT) are simulated. With varying CO2, orbit and sea ice albedo values we are able to reproduce proxy temperature records that lean towards modest levels of high latitude warming, but other proxy data showing greater warming remain beyond the reach of our model. This highlights the importance of additional proxy records at high latitudes and ongoing efforts to compare proxy signals between sites

The HadCM3 contribution to PlioMIP phase 2

We present the UK's input into the Pliocene Model Intercomparison Project phase 2 (PlioMIP2) using the Hadley Centre Climate Model version 3 (HadCM3). The 400 ppm CO2 Pliocene experiment has a mean annual surface air temperature that is 2.9 ∘C warmer than the pre-industrial and a polar amplification of between 1.7 and 2.2 times the global mean warming. The Pliocene Research Interpretation and Synoptic Mapping (PRISM4) enhanced Pliocene palaeogeography accounts for a warming of 1.4 ∘C, whilst the CO2 increase from 280 to 400 ppm leads to a further 1.5 ∘C of warming. Climate sensitivity is 3.5 ∘C for the pre-industrial and 2.9 ∘C for the Pliocene. Precipitation change between the pre-industrial and Pliocene is complex, with geographic and land surface changes primarily modifying the geographical extent of mean annual precipitation. Sea ice fraction and areal extent are reduced during the Pliocene, particularly in the Southern Hemisphere, although they persist through summer in both hemispheres. The Pliocene palaeogeography drives a more intense Pacific and Atlantic meridional overturning circulation (AMOC). This intensification of AMOC is coincident with more widespread deep convection in the North Atlantic. We conclude by examining additional sensitivity experiments and confirm that the choice of total solar insolation (1361 vs. 1365 Wm−2) and orbital configuration (modern vs. 3.205 Ma) does not significantly influence the anomaly-type analysis in use by the Pliocene community

The PRISM4 (mid-Piacenzian) paleoenvironmental reconstruction

The mid-Piacenzian is known as a period of relative warmth when compared to the present day. A comprehensive understanding of conditions during the Piacenzian serves as both a conceptual model and a source for boundary conditions and means of verification of global climate model experiments. In this paper we present the PRISM4 reconstruction, a palaeoenvironmental reconstruction of the mid-Piacenzian (~3 Ma) containing data for palaeogeography, land and sea-ice, sea-surface temperature, vegetation, soils and lakes. Our retrodicted palaeogeography takes into account glacial isostatic adjustments and changes in dynamic topography. Soils and lakes, both significant as land surface features, are introduced to the PRISM reconstruction for the first time. Sea-surface temperature and vegetation reconstructions are unchanged but now have confidence assessments. The PRISM4 reconstruction is being used as boundary condition data for the Pliocene Model Intercomparison Project, Phase 2 (PlioMIP2) experiments

A critical evaluation of the Oscillayers methods and datasets

Here we evaluate Oscillayers, a new method that aims to estimate palaeoclimates for the past 5.4 Myr, and discuss the associated theoretical and methodological issues. We show that the theoretical foundation of Oscillayers is inherently limited, because the method cannot incorporate spatio‐temporal variation and different forcing mechanisms into climate reconstructions. In addition, several methodological weaknesses are clarified that entrench the palaeoclimatic reconstruction of Oscillayers to patterns of climate change observed between the Last Glacial Maximum and current climates. We test the utility of the Oscillayers method to produce palaeoclimatic reconstructions that are similar to general circulation model (GCM)‐based estimates. On average, only 55.6% of values in the mean annual temperature datasets across the Pliocene and Pleistocene were within ±3°C when compared with corresponding GCM‐based datasets. Furthermore, on average only 75.3% of values in the mean annual precipitation datasets across the Pliocene and Pleistocene were within ±200 mm of rainfall of the GCM‐based estimates. Our results demonstrate that the Oscillayers approach does not provide a robust approximation of palaeoclimatic conditions throughout the Plio‐Pleistocene. Thus, when these datasets are used for scientific analyses, the results should be interpreted with a full appreciation of their limitations, particularly for periods outside the last glacial cycle

Atmospheric carbon dioxide, ice sheet and topographic constraints on palaeo moisture availability in Asia

Today, the hydrological regime in East and South Asia is dominated by the monsoons, whilst central Asia is characterized as arid. Studies that have examined the onset of aridity and the intensification of the monsoons in Asia have generated significant debate, especially in respect to the timing of monsoon onset and how this relates to the potential causal mechanisms. The uplift of the Tibetan Plateau, the retreat of the Paratethys Sea, and the global cooling after the Eocene/Oligocene transition are all considered major drivers of Asian aridity and monsoonal intensification. However, little is known about each of these factor's contribution to the development of modern monsoon behaviour. Here, for the first time, we perform sensitivity simulations of a fully coupled ocean–atmosphere climate model (HadCM3) to investigate the effect of the Greenland and Antarctic ice-sheets formation, atmospheric carbon dioxide (CO2) variability, and Tibetan Plateau uplift on East Central Asian aridity and monsoon driven precipitation. We focus on three individual regions, the South Asian Monsoon, the East Asian Monsoon and the Arid East Central Asia and we present the annual precipitation cycle and the moisture availability over each region. Our results show that of the parameters investigated the primary control on Asian hydroclimate is the topography of the Tibetan Plateau. Furthermore, our results highlight that the significance of each forcing depends on the component of the hydrological region and factors studied, a factor that proxy interpretation need to take into consideration

Pliocene Warmth Consistent With Greenhouse Gas Forcing

With CO2 concentrations similar to today (410 ppm), the Pliocene Epoch offers insights into climate changes under a moderately warmer world. Previous work suggested a low zonal sea surface temperature (SST) gradient in the tropical Pacific during the Pliocene, the so‐called “permanent El Niño.” Here, we recalculate SSTs using the alkenone proxy and find moderate reductions in both the zonal and meridional SST gradients during the mid‐Piacenzian warm period. These reductions are captured by coupled climate model simulations of the Pliocene, especially those that simulate weaker Walker circulation. We also produce a spatial reconstruction of mid‐Piacenzian warm period Pacific SSTs that closely resembles both Pliocene and future, low‐emissions simulations, a pattern that is, to a first order, diagnostic of weaker Walker circulation. Therefore, Pliocene warmth does not require drastic changes in the climate system—rather, it supports the expectation that the Walker circulation will weaken in the future under higher CO2

Prenatal hypoxia induces increased cardiac contractility on a background of decreased capillary density.

Background: Chronic hypoxia in utero (CHU) is one of the most common insults to fetal development and may be associated with poor cardiac recovery from ischaemia-reperfusion injury,yet the effects on normal cardiac mechanical performance are poorly understood. Methods: Pregnant female wistar rats were exposed to hypoxia (12% oxygen, balance nitrogen)for days 10–20 of pregnancy. Pups were born into normal room air and weaned normally. At 10 weeks of age, hearts were excised under anaesthesia and underwent retrograde 'Langendorff' perfusion. Mechanical performance was measured at constant filling pressure (100 cm H2O) with intraventricular balloon. Left ventricular free wall was dissected away and capillary density estimated following alkaline phosphatase staining. Expression of SERCA2a and Nitric Oxide Synthases (NOS) proteins were estimated by immunoblotting. Results: CHU significantly increased body mass (P < 0.001) compared with age-matched control rats but was without effect on relative cardiac mass. For incremental increases in left ventricular balloon volume, diastolic pressure was preserved. However, systolic pressure was significantly greater following CHU for balloon volume = 50 μl (P < 0.01) and up to 200 μl (P < 0.05). For higher balloon volumes systolic pressure was not significantly different from control. Developed pressures were correspondingly increased relative to controls for balloon volumes up to 250 μl (P < 0.05).Left ventricular free wall capillary density was significantly decreased in both epicardium (18%; P <0.05) and endocardium (11%; P < 0.05) despite preserved coronary flow. Western blot analysis revealed no change to the expression of SERCA2a or nNOS but immuno-detectable eNOS protein was significantly decreased (P < 0.001) in cardiac tissue following chronic hypoxia in utero. Conclusion: These data offer potential mechanisms for poor recovery following ischaemia, including decreased coronary flow reserve and impaired angiogenesis with subsequent detrimental effects of post-natal cardiac performance

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop

Rationale: In the endothelium, insulin stimulates endothelial NO synthase (eNOS) to generate the antiatherosclerotic signaling radical NO. Insulin-resistant type 2 diabetes mellitus is associated with reduced NO availability and accelerated atherosclerosis. The effect of enhancing endothelial insulin sensitivity on NO availability is unclear. Objective: To answer this question, we generated a mouse with endothelial cell (EC)–specific overexpression of the human insulin receptor (hIRECO) using the Tie2 promoter–enhancer. Methods and Results: hIRECO demonstrated significant endothelial dysfunction measured by blunted endothelium-dependent vasorelaxation to acetylcholine, which was normalized by a specific Nox2 NADPH oxidase inhibitor. Insulin-stimulated phosphorylation of protein kinase B was increased in hIRECO EC as was Nox2 NADPH oxidase–dependent generation of superoxide, whereas insulin-stimulated and shear stress–stimulated eNOS activations were blunted. Phosphorylation at the inhibitory residue Y657 of eNOS and expression of proline-rich tyrosine kinase 2 that phosphorylates this residue were significantly higher in hIRECO EC. Inhibition of proline-rich tyrosine kinase 2 improved insulin-induced and shear stress–induced eNOS activation in hIRECO EC. Conclusions: Enhancing insulin sensitivity specifically in EC leads to a paradoxical decline in endothelial function, mediated by increased tyrosine phosphorylation of eNOS and excess Nox2-derived superoxide. Increased EC insulin sensitivity leads to a proatherosclerotic imbalance between NO and superoxide. Inhibition of proline-rich tyrosine kinase 2 restores insulin-induced and shear stress–induced NO production. This study demonstrates for the first time that increased endothelial insulin sensitivity leads to a proatherosclerotic imbalance between NO and superoxide