18,504 research outputs found
Exoplanetary atmosphere target selection in the era of comparative planetology
The large number of new planets expected from wide-area transit surveys means
that follow-up transmission spectroscopy studies of their atmospheres will be
limited by the availability of telescope assets. We argue that telescopes
covering a broad range of apertures will be required, with even 1m-class
instruments providing a potentially important contribution. Survey strategies
that employ automated target selection will enable robust population studies.
As part of such a strategy, we propose a decision metric to pair the best
target to the most suitable telescope, and demonstrate its effectiveness even
when only primary transit observables are available. Transmission spectroscopy
target selection need not therefore be impeded by the bottle-neck of requiring
prior follow-up observations to determine the planet mass. The decision metric
can be easily deployed within a distributed heterogeneous network of telescopes
equipped to undertake either broadband photometry or spectroscopy. We show how
the metric can be used either to optimise the observing strategy for a given
telescope (e.g. choice of filter) or to enable the selection of the best
telescope to optimise the overall sample size. Our decision metric can also
provide the basis for a selection function to help evaluate the statistical
completeness of follow-up transmission spectroscopy datasets. Finally, we
validate our metric by comparing its ranked set of targets against lists of
planets that have had their atmospheres successfully probed, and against some
existing prioritised exoplanet lists.Comment: 20 pages, 16 figures, 3 tables. Revision 3, accepted by MNRAS.
Improvements include always using planetary masses where available and
reliable, treatment for sky backgrounds and out-of-transit noise and a use
case for defocused photometr
A heralded quantum gate between remote quantum memories
We demonstrate a probabilistic entangling quantum gate between two distant
trapped ytterbium ions. The gate is implemented between the hyperfine "clock"
state atomic qubits and mediated by the interference of two emitted photons
carrying frequency encoded qubits. Heralded by the coincidence detection of
these two photons, the gate has an average fidelity of 90+-2%. This entangling
gate together with single qubit operations is sufficient to generate large
entangled cluster states for scalable quantum computing
Identifying influential spreaders and efficiently estimating infection numbers in epidemic models: a walk counting approach
We introduce a new method to efficiently approximate the number of infections
resulting from a given initially-infected node in a network of susceptible
individuals. Our approach is based on counting the number of possible infection
walks of various lengths to each other node in the network. We analytically
study the properties of our method, in particular demonstrating different forms
for SIS and SIR disease spreading (e.g. under the SIR model our method counts
self-avoiding walks). In comparison to existing methods to infer the spreading
efficiency of different nodes in the network (based on degree, k-shell
decomposition analysis and different centrality measures), our method directly
considers the spreading process and, as such, is unique in providing estimation
of actual numbers of infections. Crucially, in simulating infections on various
real-world networks with the SIR model, we show that our walks-based method
improves the inference of effectiveness of nodes over a wide range of infection
rates compared to existing methods. We also analyse the trade-off between
estimate accuracy and computational cost, showing that the better accuracy here
can still be obtained at a comparable computational cost to other methods.Comment: 6 page
Summary of a Crew-Centered Flight Deck Design Philosophy for High-Speed Civil Transport (HSCT) Aircraft
Past flight deck design practices used within the U.S. commercial transport aircraft industry have been highly successful in producing safe and efficient aircraft. However, recent advances in automation have changed the way pilots operate aircraft, and these changes make it necessary to reconsider overall flight deck design. Automated systems have become more complex and numerous, and often their inner functioning is partially or fully opaque to the flight crew. Recent accidents and incidents involving autoflight system mode awareness Dornheim, 1995) are an example. This increase in complexity raises pilot concerns about the trustworthiness of automation, and makes it difficult for the crew to be aware of all the intricacies of operation that may impact safe flight. While pilots remain ultimately responsible for mission success, performance of flight deck tasks has been more widely distributed across human and automated resources. Advances in sensor and data integration technologies now make far more information available than may be prudent to present to the flight crew
The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome of invasive ductal breast carcinoma
Aims: To clarify MUC1 patterns in invasive ductal breast carcinoma and to relate them to clinicopathological parameters, coexpression of other biological markers and prognosis. Methods and results: Samples from 243 consecutive patients with primary ductal carcinoma were incorporated into tissue microarrays (TMAs). Slides were stained for MUC1, oestrogen receptor (ER), progesterone receptor (PR), Her2/neu, p53 and cyclin D1. Apical membrane MUC1 expression was associated with smaller tumours (P = 0.001), lower tumour grades (P < 0.001), PR positivity (P = 0.003) and increased overall survival (OS; P = 0.030). Diffuse cytoplasmic MUC1 expression was associated with cyclin D1 positivity (P = 0.009) and increased relapse-free survival (RFS; P = 0.034). Negativity for MUC1 was associated with ER negativity (P = 0.004), PR negativity (P = 0.001) and cyclin D1 negativity (P = 0.009). In stepwise multivariate analysis MUC1 negativity was an independent predictor of both RFS [hazard ratio (HR) 3.5, 95% confidence interval (CI) 1.5, 8.5; P = 0.005] and OS (HR 14.7, 9 5% Cl 4.9, 44. 1; P < 0.001). Conclusions: The expression pattern of MUC1 in invasive ductal breast carcinoma is related to tumour characteristics and clinical outcome. In addition, negative MUC1 expression is an independent risk factor for poor RFS and OS, besides 'classical' prognostic indicators
Evaluating current and forthcoming proposals on JHA databases and a smart borders system at EU external borders
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