Tissue eosinophilia and eosinophil degranulation in Riedel's invasive fibrous thyroiditis.

The etiology of Riedel's invasive fibrous thyroiditis (IFT) has remained obscure. This rare disorder has been confused in the past with the more common fibrous variant of Hashimoto's disease. The typical histological features of IFT, in particular the presence of an invasive fibrosclerotic process in conjunction with a prominent chronic inflammatory infiltrate, suggest that the release of fibrogenic cytokines and other factors from these cellular infiltrates may play an important role in the pathogenesis of this condition. Our observations in routinely processed tissue sections obtained from patients with documented IFT of striking tissue eosinophilia led us to hypothesize that eosinophils and their products may play a role in the evolution of this disease. Immunofluorescence staining with affinity-purified polyclonal rabbit antibody directed against human eosinophil granule major basic protein revealed marked tissue eosinophilia and abundant extracellular deposition of major basic protein in all specimens from 16 patients with IFT. By contrast, only occasional eosinophils and no extracellular major basic protein were detected in control thyroid tissues obtained from patients with multinodular goiter, Graves' disease, Hashimoto's disease, and normal thyroid tissue. The presence of marked eosinophil infiltration and extracellular major basic protein deposition in IFT and other associated fibrosclerotic conditions suggests a role for eosinophils and their products in propagating the fibrogenesis seen in IFT

Users manual for the US baseline corn and soybean segment classification procedure

A user's manual for the classification component of the FY-81 U.S. Corn and Soybean Pilot Experiment in the Foreign Commodity Production Forecasting Project of AgRISTARS is presented. This experiment is one of several major experiments in AgRISTARS designed to measure and advance the remote sensing technologies for cropland inventory. The classification procedure discussed is designed to produce segment proportion estimates for corn and soybeans in the U.S. Corn Belt (Iowa, Indiana, and Illinois) using LANDSAT data. The estimates are produced by an integrated Analyst/Machine procedure. The Analyst selects acquisitions, participates in stratification, and assigns crop labels to selected samples. In concert with the Analyst, the machine digitally preprocesses LANDSAT data to remove external effects, stratifies the data into field like units and into spectrally similar groups, statistically samples the data for Analyst labeling, and combines the labeled samples into a final estimate

Incontinence-specific quality of life measures used in trials of treatments for female urinary incontinence: a systematic review.

This systematic review examined the use of incontinence-specific QOL measures in clinical trials of female incontinence treatments, and systematically evaluated their quality using a standard checklist. Of 61 trials included in the review, 58 (95.1%) used an incontinence-specific QOL measure. The most commonly used were IIQ (19 papers), I-QoL (12 papers) and UDI (9 papers). Eleven papers (18.0%) used measures which were not referenced or were developed specifically for the study. The eight QOL measures identified had good clinical face validity and measurement properties. We advise researchers to evaluate carefully the needs of their specific study, and select the QOL measure that is most appropriate in terms of validity, utility and relevance, and discourage the development of new measures. Until better evidence is available on the validity and comparability of measures, we recommend that researchers consider using IIQ or I-QOL with or without UDI in trials of incontinence treatments

Regional agriculture surveys using ERTS-1 data

The Center for Remote Sensing Research has conducted studies designed to evaluate the potential application of ERTS data in performing agricultural inventories, and to develop efficient methods of data handling and analysis useful in the operational context for performing large area surveys. This work has resulted in the development of an integrated system utilizing both human and computer analysis of ground, aerial, and space imagery, which has been shown to be very efficient for regional crop acreage inventories. The technique involves: (1) the delineation of ERTS images into relatively homogeneous strata by human interpreters, (2) the point-by-point classification of the area within each strata on the basis of crop type using a human/machine interactive digital image processing system; and (3) a multistage sampling procedure for the collection of supporting aerial and ground data used in the adjustment and verification of the classification results

The contribution of social work field education to work-integrated learning.

The International Journal of Work-Integrated Learning is an Open Access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author.fals

Blind spots in IPE : marginalized perspectives and neglected trends in contemporary capitalism

Which blind spots shape scholarship in International Political Economy (IPE)? That question animates the contributions to a double special issue—one in the Review of International Political Economy, and a companion one in New Political Economy. The global financial crisis had seemed to vindicate broad-ranging IPE perspectives at the expense of narrow economics theories. Yet the tumultuous decade since then has confronted IPE scholars with rapidly-shifting global dynamics, many of which had remained underappreciated. We use the Blind Spots moniker in an attempt to push the topics covered here higher up the scholarly agenda—issues that range from institutionalized racism and misogyny to the rise of big tech, intensifying corporate power, expertise-dynamics in global governance, assetization, and climate change. Gendered and racial inequalities as blind spots have a particular charge. There has been a self-reinforcing correspondence between topics that have counted as important, people to whom they matter personally, and the latter’s ability to build careers on them. In that sense, our mission is not only to highlight collective blind spots that may dull IPE’s capacity to theorize the current moment. It is also a normative one—a form of disciplinary housekeeping to help correct both intellectual and professional entrenched biases