Predictors of positive growth after traumatic brain injury : a longitudinal study

Primary objective: To investigate long-term positive psychological growth in individuals with traumatic brain injury (TBI) and to relate growth to injury characteristics and early outcomes. Research design: Longitudinal study. Method and Procedure: Long-term follow-up of a group of TBI survivors recruited between 1991-1995. In 2004, 240 of the 563 original participants were invited to take part in a follow-up study. At follow-up, survivors completed the Positive Changes in Outlook Questionnaire (CiOP) along with a structured interview/questionnaire which permitted a Glasgow Outcome Scale (GOSE) score to be assigned. Results: 165 TBI survivors completed both questionnaire and CiOP. 103(62%) participants had suffered severe TBI, 24(15%) moderate and 38(23%) mild. Mean length of follow-up was 11.5 years post-injury (range 9-25 years). On the GOSE at follow-up, 43(26%) had severe disability; 72(44%) moderate disability; and 50(30%) good recovery. Scores on the CiOP indicated positive psychological growth in over half of the sample, as evidenced by agreement with items such as “I don’t take life for granted anymore” and “I value my relationships much more now”. CiOP total scores did not correlate with any injury or early outcome variables. However, at long-term follow-up there was a negative correlation between positive growth and anxiety and depression. Conclusion: Survivors of mild, moderate and severe TBI showed evidence of long-term positive changes in outlook

Evolutionary attitudes and literacy survey (EALS): Development and validation of a short form

This is the publisher's version, also available electronically from http://link.springer.com/article/10.1007%2Fs12052-012-0429-7.The Evolutionary Attitudes and Literacy Survey (EALS) is a multidimensional scale consisting of 16 lower- and 6 higher-order constructs developed to measure the wide array of factors that influence both an individual’s endorsement of and objection to evolutionary theory. Past research has demonstrated the validity and utility of the EALS (Hawley et al., Evol Educ Outreach 4:117–132, 2011); however, the 104-item long-form scale may be excessive for researchers and educators. The present study sought to reduce the number of items in the EALS while maintaining the validity and structure of the long form. For the present study, and following best practices for short-form construction, we surveyed a new sample of several hundred undergraduates from multiple majors and reduced the long form by 40% while maintaining the scale structure and validity. A multiple-group confirmatory factor analysis supported strong factorial invariance across samples, and therefore verified structure and pattern between the six higher-order constructs of the long-form EALS and the EALS short form (EALS-SF). Regression analysis further demonstrated the short form’s validity (i.e., demographics and openness to experience) and replicated previous findings. In the end, the EALS-SF may be a versatile tool that may be used whole or in part for a variety of research areas, including curricular effectiveness of courses on evolution and/or biology

Evolutionary Attitudes and Literacy Survey (EALS): Development and Validation of a Short Form

This is the publisher's version, also available electronically from http://link.springer.com/article/10.1007%2Fs12052-012-0429-7.The Evolutionary Attitudes and Literacy Survey (EALS) is a multidimensional scale consisting of 16 lower- and 6 higher-order constructs developed to measure the wide array of factors that influence both an individual’s endorsement of and objection to evolutionary theory. Past research has demonstrated the validity and utility of the EALS (Hawley et al., Evol Educ Outreach 4:117–132, 2011); however, the 104-item long-form scale may be excessive for researchers and educators. The present study sought to reduce the number of items in the EALS while maintaining the validity and structure of the long form. For the present study, and following best practices for short-form construction, we surveyed a new sample of several hundred undergraduates from multiple majors and reduced the long form by 40% while maintaining the scale structure and validity. A multiple-group confirmatory factor analysis supported strong factorial invariance across samples, and therefore verified structure and pattern between the six higher-order constructs of the long-form EALS and the EALS short form (EALS-SF). Regression analysis further demonstrated the short form’s validity (i.e., demographics and openness to experience) and replicated previous findings. In the end, the EALS-SF may be a versatile tool that may be used whole or in part for a variety of research areas, including curricular effectiveness of courses on evolution and/or biology

Hydrogen Balmer Line Broadening in Solar and Stellar Flares

The broadening of the hydrogen lines during flares is thought to result from increased charge (electron, proton) density in the flare chromosphere. However, disagreements between theory and modeling prescriptions have precluded an accurate diagnostic of the degree of ionization and compression resulting from flare heating in the chromosphere. To resolve this issue, we have incorporated the unified theory of electric pressure broadening of the hydrogen lines into the non-LTE radiative transfer code RH. This broadening prescription produces a much more realistic spectrum of the quiescent, A0 star Vega compared to the analytic approximations used as a damping parameter in the Voigt profiles. We test recent radiative-hydrodynamic (RHD) simulations of the atmospheric response to high nonthermal electron beam fluxes with the new broadening prescription and find that the Balmer lines are over-broadened at the densest times in the simulations. Adding many simultaneously heated and cooling model loops as a "multithread" model improves the agreement with the observations. We revisit the three-component phenomenological flare model of the YZ CMi Megaflare using recent and new RHD models. The evolution of the broadening, line flux ratios, and continuum flux ratios are well-reproduced by a multithread model with high-flux nonthermal electron beam heating, an extended decay phase model, and a "hot spot" atmosphere heated by an ultrarelativistic electron beam with reasonable filling factors: 0.1%, 1%, and 0.1% of the visible stellar hemisphere, respectively. The new modeling motivates future work to understand the origin of the extended gradual phase emission.Comment: 31 pages, 13 figures, 2 tables, accepted for publication in the Astrophysical Journa

Pseudoangiomatous Stromal Hyperplasia: A Case Report

Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign proliferating breast condition. It was first reported in 1986 when Vuitch, Rosen, and Erlandson described nine cases of benign well-circumscribed, breast masses that simulated vascular lesions consisting of mammary stromal proliferations (Vuitch et al. (1986)). Since then there have been few reported cases of PASH in the literature (Taira et al. (2005)). We describe a large PASH, mimicking inflammatory carcinoma in a young lady that was excised with excellent cosmetic results

What's the Matter with Kansas?: The Development and Confirmation of the Evolutionary Attitudes and Literacy Survey (EALS)

This is the publisher's version, also available electronically from http://link.springer.com/article/10.1007%2Fs12052-010-0294-1.The present survey was designed to assess predominant regional belief systems and the roles these beliefs play in science understanding and attitudes, and curricular effectiveness in colleges and universities. To this end, we created a wide variety of theory-driven subscales (lower order factors) reflecting, for example, exposure to evolutionary material, young earth creationist beliefs, moral and social objections, political ideology, endorsement of intelligent design fallacies, knowledge (and distrust) of the scientific enterprise, and attitudes of evolutionary theory’s relevance in several domains (e.g., sciences and humanities). We also included potentially important demographic variables (e.g., rural upbringing, family size). Finally, we assessed openness to experience, a key facet of personality. Hierarchical Structural Equation Modeling (SEM) analysis showed the 16 constructs to have a theoretically meaningful and quantitatively coherent higher order factor structure. In this large Kansas sample of university students, creationist reasoning and conservative orientation (political and religious) were negatively associated with exposure to evolutionary theory, knowledge about it, and positive attitudes toward its relevance. At the same time, exposure to the theory was positively associated with knowledge and positive attitudes. Importantly, though most Kansas-specific demographic variables (e.g., rural origins) were largely unrelated to outcomes of interest in this university-based sample, the personality factor openness to experience appears to be highly relevant for several higher order factors (e.g., exposure, knowledge and relevance, and creationist reasoning). We close with implications for educators and the next steps in survey development

What's the Matter with Kansas?: The Development and Confirmation of the Evolutionary Attitudes and Literacy Survey (EALS)

This is the publisher's version, also available electronically from http://link.springer.com/article/10.1007%2Fs12052-010-0294-1.The present survey was designed to assess predominant regional belief systems and the roles these beliefs play in science understanding and attitudes, and curricular effectiveness in colleges and universities. To this end, we created a wide variety of theory-driven subscales (lower order factors) reflecting, for example, exposure to evolutionary material, young earth creationist beliefs, moral and social objections, political ideology, endorsement of intelligent design fallacies, knowledge (and distrust) of the scientific enterprise, and attitudes of evolutionary theory’s relevance in several domains (e.g., sciences and humanities). We also included potentially important demographic variables (e.g., rural upbringing, family size). Finally, we assessed openness to experience, a key facet of personality. Hierarchical Structural Equation Modeling (SEM) analysis showed the 16 constructs to have a theoretically meaningful and quantitatively coherent higher order factor structure. In this large Kansas sample of university students, creationist reasoning and conservative orientation (political and religious) were negatively associated with exposure to evolutionary theory, knowledge about it, and positive attitudes toward its relevance. At the same time, exposure to the theory was positively associated with knowledge and positive attitudes. Importantly, though most Kansas-specific demographic variables (e.g., rural origins) were largely unrelated to outcomes of interest in this university-based sample, the personality factor openness to experience appears to be highly relevant for several higher order factors (e.g., exposure, knowledge and relevance, and creationist reasoning). We close with implications for educators and the next steps in survey development

Driving in stroke survivors aged 18–65 years: The Psychosocial Outcomes In StrokE (POISE) Cohort Study

Background: There is limited information regarding return to driving after stroke. Aims: To determine the frequency and predictors of return to driving within 1 month of acute stroke in younger (age 18–65 years) adults. Methods: POISE (Psychosocial Outcomes In StrokE) was a cohort study conducted in Australia between October 2008 and June 2010. Consecutive patients (age 18–65 years) with a recent (≤28 days) acute stroke were recruited. Validated demographic, clinical, mental health, cognitive, and disability measures including return to driving were obtained. Multivariable logistic regression was used to determine factors associated with return to driving within 1 month of stroke. Results: Among 359 participants who were legally able to drive before stroke, 96 (26.7%) returned to driving within 1 month. Compared to those without an early return to driving (n = 263), drivers were more often male, the main income earner, in paid work before stroke and without symptoms of depression or fatigue. Independence in activities of daily living (odds ratio (OR) 30.05, 95% confidence interval (CI) 3.85–234.45), not recalling receiving advice on driving cessation (OR 5.55, 95% CI 2.86–11.11), and having returned to paid work (OR 3.93, 95% CI 1.94–7.96) were associated with early return to driving. Conclusions: One in four young adults resumed driving within a month, contrary to guideline recommendations. These data reinforce the importance of deciding who is responsible for determining fitness to drive after stroke, when, and whether it is reasonable to enforce driving restrictions on those with minimal disability who are fit to return to work. Registration: Australian New Zealand Clinical Trials Registry ANZCTRN 12608000459325

Stratified randomization controls better for batch effects in 450K methylation analysis: a cautionary tale

Background: Batch effects in DNA methylation microarray experiments can lead to spurious results if not properly handled during the plating of samples. Methods: Two pilot studies examining the association of DNA methylation patterns across the genome with obesity in Samoan men were investigated for chip- and row-specific batch effects. For each study, the DNA of 46 obese men and 46 lean men were assayed using Illumina's Infinium HumanMethylation450 BeadChip. In the first study (Sample One), samples from obese and lean subjects were examined on separate chips. In the second study (Sample Two), the samples were balanced on the chips by lean/obese status, age group, and census region. We used methylumi, watermelon, and limma R packages, as well as ComBat, to analyze the data. Principal component analysis and linear regression were respectively employed to identify the top principal components and to test for their association with the batches and lean/obese status. To identify differentially methylated positions (DMPs) between obese and lean males at each locus, we used a moderated t-test.Results: Chip effects were effectively removed from Sample Two but not Sample One. In addition, dramatic differences were observed between the two sets of DMP results. After removing'' batch effects with ComBat, Sample One had 94,191 probes differentially methylated at a q-value threshold of 0.05 while Sample Two had zero differentially methylated probes. The disparate results from Sample One and Sample Two likely arise due to the confounding of lean/obese status with chip and row batch effects.Conclusion: Even the best possible statistical adjustments for batch effects may not completely remove them. Proper study design is vital for guarding against spurious findings due to such effects