Recruiting and retaining children and families' social workers. The potential of work discussion groups

Current difficulties with the recruitment and retention of children and families' social workers have been formally acknowledged. However, although initiatives which focus on remuneration and career progression are clearly welcome, research and evidence from practice highlights how social workers themselves place high value on the availability of good quality supervision. Yet, questions remain about whether first-line managers have the time or are even in the best position to offer this support. This article draws on the experience and evaluation of one particular model of supervision — 'work discussion groups' —and explores its impact with residential social work staff and teachers as well as the potential for further developments of this kind

Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission from Depression.

BACKGROUND: Ketamine as an antidepressant improves anhedonia as early as 2h post-infusion. These drug effects are thought to be exerted via actions on reward-related brain areas-yet, these actions remain largely unknown. Our study investigates ketamine's effects during the anticipation and receipt of an expected reward, after the psychotomimetic effects of ketamine have passed, when early antidepressant effects are reported. METHODS: We examined ketamine's effects during the anticipation and receipt of expected rewards on pre-defined brain areas, namely the dorsal and ventral striatum, the ventral tegmental area, the amygdala and the insula. We have recruited 37 male and female participants who remitted from depression and were free from symptoms and antidepressant treatments at the time of the scan. Participants were scanned, 2h after drug administration, in a double-blind cross over design (ketamine:0.5mg/kg and placebo) while performing a monetary reward task. RESULTS: A significant main effect of ketamine, across all ROIs, was observed during the anticipation and feedback phases of win and no-win trials. The drug effects were particularly prominent in the nucleus accumbens and putamen, which showed increased activation upon the receipt of smaller rewards compared to neutral. The levels of (2R,6R)-HNK, 2h post-infusion, significantly correlated with the activation observed in the ventral tegmental area for that contrast. CONCLUSIONS: These findings demonstrate that ketamine can produce detectable changes in reward-related brain areas, 2h after infusion, which occur without symptom changes and support the idea that ketamine might improve reward-related symptoms via modulation of response to feedback

A systematic review of community participation measures for people with intellectual disabilities

Background: Community participation is considered a fundamental aspect of quality of life and one of the essential goals of services for people with intellectual disabilities (ID), yet there is no agreed way of measuring community participation. Method: Two systematic searches were performed across eight electronic databases to identify measures of community participation and identify validation studies for each measure. Measures were included if they were developed for adults with ID, measured extent of participation and had published information regarding content and psychometric properties. Each measure was evaluated on the basis of psychometric properties and in relation to coverage of nine domains of community participation from the International Classification of Functioning, Disability and Health (ICF). Results: Eleven measures were selected with the quality rating scores varying substantially ranging from 2-11 of a possible 16. Conclusions: The majority of measures were not sufficiently psychometrically tested. Findings suggest a need for the development of a psychometrically robust instrument

A Study of CO Emission in High Redshift QSOs Using the Owens Valley Millimeter Array

Searches for CO emission in high-redshift objects have traditionally suffered from the accuracy of optically-derived redshifts due to lack of bandwidth in correlators at radio observatories. This problem has motivated the creation of the new COBRA continuum correlator, with 4 GHz available bandwidth, at the Owens Valley Radio Observatory Millimeter Array. Presented here are the first scientific results from COBRA. We report detections of redshifted CO(J=3-2) emission in the QSOs SMM J04135+10277 and VCV J140955.5+562827, as well as a probable detection in RX J0911.4+0551. At redshifts of z=2.846, z=2.585, and z=2.796, we find integrated CO flux densities of 5.4 Jy km/s, 2.4 Jy km/s, and 2.9 Jy km/s for SMM J04135+10277, VCV J140955.5+562827, and RX J0911.4+0551, respectively, over linewidths of Delta(V_{FWHM}) ~ 350 km/s. These measurements, when corrected for gravitational lensing, correspond to molecular gas masses of order M(H_2) ~ 10^{9.6-11.1} solar masses, and are consistent with previous CO observations of high-redshift QSOs. We also report 3-sigma upper limits on CO(3-2) emission in the QSO LBQS 0018-0220 of 1.3 Jy km/s. We do not detect significant 3mm continuum emission from any of the QSOs, with the exception of a tentative (3-sigma) detection in RX J0911.4+0551 of S_{3mm}=0.92 mJy/beam.Comment: 18 pages, 5 figures, 2 tables, accepted to ApJ. Changes made for version 2: citations added, 2 objects added to Table 2 and Figure

Ultracompact monolithic integration of balanced, polarization diversity photodetectors for coherent lightwave receivers

The authors have monolithically integrated an optical front-end on InP for balanced, polarization-diversity coherent lightwave reception which is only 1.3-mm long. Low on-chip insertion loss (<4.5 dB) and balanced photoresponse (1.05:1 or better) are achieved at 1.5-μm wavelength using straightforward, regrowth-free fabrication. Low-capacitance photodetectors (≤0.15 pF) are employed for high bandwidth operation

Space Velocities of L- and T-type Dwarfs

(Abridged) We have obtained radial velocities of a sample of 18 ultracool dwarfs (M6.5-T8) using high-resolution, near-infrared spectra obtained with NIRSPEC and the Keck II telescope. We have confirmed that the radial velocity of Gl 570 D is coincident with that of the K-type primary star Gl 570 A, thus providing additional support for their true companionship. The presence of planetary-mass companions around 2MASS J05591914-1404488 (T4.5V) has been analyzed using five NIRSPEC radial velocity measurements obtained over a period of 4.37 yr. We have computed UVW space motions for a total of 21 L and T dwarfs within 20 pc of the Sun. This population shows UVW velocities that nicely overlap the typical kinematics of solar to M-type stars within the same spatial volume. However, the mean Galactic (44.2 km/s) and tangential (36.5 km/s) velocities of the L and T dwarfs appear to be smaller than those of G to M stars. A significant fraction (~40%) of the L and T dwarfs lies near the Hyades moving group (0.4-2 Gyr), which contrasts with the 10-12% found for earlier-type stellar neighbors. Additionally, the distributions of all three UVW components (sigma_{UVW} = 30.2, 16.5, 15.8 km/s) and the distributions of the total Galactic (sigma_{v_tot} = 19.1 km/s) and tangential (sigma_{v_t} = 17.6 km/s) velocities derived for the L and T dwarf sample are narrower than those measured for nearby G, K, and M-type stars, but similar to the dispersions obtained for F stars. This suggests that, in the solar neighborhood, the L- and T-type ultracool dwarfs in our sample (including brown dwarfs) is kinematically younger than solar-type to early M stars with likely ages in the interval 0.5-4 Gyr.Comment: Accepted for publication in Ap

Fibroblast Growth Factor 23 (FGF23) and Alpha-Klotho Stimulate Osteoblastic MC3T3.E1 Cell Proliferation and Inhibit Mineralization

Elevated serum levels of the phosphate-regulating hormone fibroblast growth factor 23 (FGF23) are found in patients with phosphate wasting diseases and chronic kidney disease-mineral and bone disorder (CKD-MBD). These diseases are associated with rickets and renal osteodystrophy, respectively. FGF23 is secreted from osteoblastic cells and signals through FGFRs, membrane coreceptor alpha-Klotho (Klotho), and, possibly, a circulating form of Klotho. Despite the absence of detectable Klotho on osteoblastic cells, studies have suggested that forced FGF23 expression in osteoblasts inhibited mineralization. Thus, we examined the effects of exogenously applied FGF23 on osteoblastic MC3T3.E1 cell proliferation and differentiation, with and without soluble Klotho. MC3T3.E1 cells were cultured in osteoblast differentiation medium, supplemented with FGF23 (0.1–1,000 ng/mL), Klotho (50 ng/mL), the combination FGF23 + Klotho, and FGF2 (100 ng/mL) as a control. Neither FGF23 nor Klotho exposure affected proliferation of day 4 growth phase cells or mineralization of day 14 cultures. In contrast, FGF23 + Klotho resulted in inhibition of mineralization and osteoblast activity markers at day 14, and a slight, reproducible induction of proliferation. Inhibition of FGFR1, but not FGFR2 or FGFR3, completely restored FGF23 + Klotho-induced inhibition of alkaline phosphatase (ALP) activity at day 7. ALP activity was partially restored by the MAPK inhibitor U0126 but not inhibitors p38 and P13K. Thus, soluble Klotho enables FGF23 signaling in MC3T3.E1 cells, likely through FGFR 1(IIIc). Elevated FGF23 actions, in part, appear to parallel FGF2 with lower potency. In addition to affecting bone via indirect phosphate wasting pathways, supraphysiological FGF23 and soluble Klotho may directly impact bone in diseases with elevated FGF23 levels

Cyclopropanation using flow-generated diazo compounds.

We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of different diazo species to generate functionalised cyclopropanes which are valuable 3D building blocks.We are grateful to Pfizer Worldwide Research and Development (CB, RJI and JMH), the Swiss National Science Foundation (DNT), CAPES (RL, no 9865/13-6) and the EPSRC (SVL, grant no EP/K0099494/1 and no EP/K039520/1) for financial support.This is the final published article, originally published in Organic & Biomolecular Chemistry, 2015,13, 2550-2554 DOI: 10.1039/C5OB00019

Evidence for pyrazine-based chromophores in cloud water mimics containing methylglyoxal and ammonium sulfate

Simulating aqueous brown carbon (aqBrC) formation from small molecule amines and aldehydes in cloud water mimics provides insight into potential humic-like substance (HULIS) contributors and their effect on local and global aerosol radiative forcing. Previous work has shown that these (Maillard type) reactions generate products that are chemically, physically, and optically similar to atmospheric HULIS in many significant ways, including in their complexity. Despite numerous characterization studies, attribution of the intense brown color of many aqBrC systems to specific compounds remains incomplete. In this work, we present evidence of novel pyrazine-based chromophores (PBCs) in the product mixture of aqueous solutions containing methylglyoxal and ammonium sulfate. PBCs observed here include 2,5-dimethyl pyrazine (DMP) and products of methylglyoxal addition to the pyrazine ring. This finding is significant as the literature of Maillard reactions in food chemistry tightly links the formation of pyrazine (and related compounds) to browning in foods. We investigated the roles of both cloud processing (by bulk evaporation) and pH in absorptivity and product distribution in microliter samples to understand the contribution of these PBCs to aqBrC properties. In agreement with previous work, we observed elevated absorptivity across the entire UV–visible spectrum following simulated cloud processing as well as higher absorptivity in more basic samples. Absorptivity of the pH 2 sample, following evaporation over a period of days, exceeded that of the unevaporated pH 9 sample. In addition, mixtures of ammonium sulfate and methylglyoxal at pH 5 that were dried in under 1&thinsp;h and analyzed 24&thinsp;h later were as absorptive as pH 9 samples allowed to react for 7 days, indicating that evaporation occurring during cloud processing may provide a reaction pathway favorable for carbonyl–ammonia chemistry even under acidic conditions of aerosol and cloud water. The fraction of pyrazine compounds in the product mixture increased by up to a factor of 4 in response to drying with a maximum observed contribution of 16&thinsp;% at pH 5. Therefore, cloud processing under acidic conditions may produce PBCs at the expense of imine- and imidazole-derived compounds. This finding has implications for further BrC reactivity and degradation pathways.</p

Ranking ligand affinity for the DNA minor groove by experiment and simulation

The structural and thermodynamic basis for the strength and selectivity of the interactions of minor-groove binders (MGBs) with DNA is not fully understood. In 2003 we reported the first example of a thiazole containing MGB that bound in a phase shifted pattern that spanned 6 base-pairs rather than the usual 4 (for tricyclic distamycin-like compounds). Since then, using DNA footprinting, nuclear magnetic resonance spectroscopy, isothermal titration calorimetry and molecular dynamics, we have established that the flanking bases around the central 4 being read by the ligand have subtle effects on recognition. We have investigated the effect of these flanking sequences on binding and the reasons for the differences and established a computational method to rank ligand affinity against varying DNA sequences