9,769 research outputs found
Broadcasting graphic war violence: the moral face of Channel 4
Drawing on empirical data from Channel 4 (C4) regarding the broadcasting of violent war imagery, and positioned within Goffman’s notion of the interaction ritual (1959, 1967), this article investigates how C4 negotiate potentially competing commercial, regulatory and moral requirements through processes of discretionary decision-making. Throughout, the article considers the extent to which these negotiations are presented through a series of ‘imaginings’ – of C4 and its audience – which serve to simultaneously guide and legitimate the decisions made. This manifestation of imaginings moves us beyond more blanket explanations of ‘branding’ and instead allows us to see the final programmes as the end product of a series of complex negotiations and interactions between C4 and those multiple external parties significant to the workings of their organization. The insights gleaned from this case study are important beyond the workings of C4 because they help elucidate how all institutions and organizations may view, organize and justify their practices (to both themselves and others) within the perceived constraints in which they operate
The pursuit of ignorance:The UK’s anti-lobbying clause will jeopardise evidence informed policy making
No abstract available
Supernovae in Low-Redshift Galaxy Clusters: Observations by the Wise Observatory Optical Transient Search (WOOTS)
We describe the Wise Observatory Optical Transient Search (WOOTS), a survey
for supernovae (SNe) and other variable and transient objects in the fields of
redshift 0.06-0.2 Abell galaxy clusters. We present the survey design and
data-analysis procedures, and our object detection and follow-up strategies. We
have obtained follow-up spectroscopy for all viable SN candidates, and present
the resulting SN sample here. Out of the 12 SNe we have discovered, seven are
associated with our target clusters while five are foreground or background
field events. All but one of the SNe (a foreground field event) are Type Ia
SNe. Our non-cluster SN sample is uniquely complete, since all SN candidates
have been either spectroscopically confirmed or ruled out. This allows us to
estimate that flux-limited surveys similar to WOOTS would be dominated (~80%)
by SNe Ia. Our spectroscopic follow-up observations also elucidate the
difficulty in distinguishing active galactic nuclei from SNe. In separate
papers we use the WOOTS sample to derive the SN rate in clusters for this
redshift range, and to measure the fraction of intergalactic cluster SNe. We
also briefly report here on some quasars and asteroids discovered by WOOTS.Comment: Submitted to ApJ. Comments welcom
The CARMA correlator
The Combined Array for Research in Millimeter-wave Astronomy (CARMA) requires a flexible correlator to process the data from up to 23 telescopes and up to 8GHz of receiver bandwidth. The Caltech Owens Valley Broadband Reconfigurable Array (COBRA) correlator, developed for use at the Owens Valley millimeter-wave array and being used by the Sunyaev-Zeldovich Array (SZA), will be adapted for use by CARMA. The COBRA correlator system, a hybrid analog-digital design, consisting of downconverters, digitizers and correlators will be presented in this paper. The downconverters receive an input IF of 1-9GHz and produce a selectable output bandwidth of 62.5MHz, 125MHz, 250MHz, or 500MHz. The downconverter output is digitized at 1Gsample/s to 2-bits per sample. The digitized data is optionally digitally filtered to produce bands narrower than 62.5MHz (down to 2MHz). The digital correlator system is a lag- or XF-based system implemented using Field-Programmable Gate Arrays (FPGAs). The digital system implements delay lines, calculates the autocorrelations for each antenna, and the cross-correlations for each baseline. The number of lags, and hence spectral channels, produced by the system is a function of the input bandwidth; with the 500MHz band having the coarsest resolution, and the narrowest bandwidths having the finest resolution
An evaluation of antipseudomonal dosing on the incidence of treatment failure
Introduction: Significant mortality is associated with delays in appropriate antibiotic therapy in Pseudomonas aeruginosa infections. The impact of empiric dosing on clinical outcomes has been largely unreported. Methods: This retrospective cohort compared treatment failure in patients receiving guideline-concordant or guideline-discordant empiric therapy with cefepime, meropenem, or piperacillin/tazobactam. Patients with culture-positive P. aeruginosa between 1 July 2013 and 31 July 2019 were eligible for inclusion. Patients with cystic fibrosis, polymicrobial infection, and urinary or pulmonary colonization were excluded. The composite primary outcome was treatment failure, defined as (1) therapy modification due to resistance/perceived treatment failure, (2) increased/unchanged qSOFA, or (3) persistent fever 48 h after initiating appropriate therapy. Secondary outcomes included rate of infectious diseases consultation, all-cause inpatient mortality, mechanical ventilation requirement, and infection-related intensive care unit and hospital lengths of stay. Results: In total, 198 patients were included: 90 guideline-concordant and 108 guideline-discordant. Baseline characteristics were balanced. Treatment failure was more common in the guideline-discordant than the guideline-concordant group (62% versus 48%; p = 0.04). This remained significant when adjusting for supratherapeutic dosing (p = 0.02). Infectious diseases consultation was higher in the guideline-discordant group (46% versus 29%, p = 0.01), while intensive care unit length of stay was longer in the guideline-concordant group (4.5 versus 3 days, p = 0.03). Additional secondary outcomes were similar. Conclusion: Treatment failure was significantly higher in patients receiving guideline-discordant empiric antipseudomonal dosing. Guideline-directed dosing, disease states, and patient-specific factors should be assessed when considering empiric antipseudomonal dosing
Coarse-grained model of entropic allostery
Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via a conformational change in response to the ligand binding. An alternative entropic mechanism of "allostery" suggests that the inducer ligand changes the intramolecular vibrational entropy, not just the mean static structure. We present a quantitative, coarse-grained model of entropic allostery, which suggests design rules for internal cohesive potentials in proteins employing this effect. It also addresses the issue of how the signal information to bind or unbind is transmitted through the protein. The model may be applicable to a wide range of repressors and also to signaling in trans-membrane proteins
Chemical Doppelgangers in GALAH DR3: the Distinguishing Power of Neutron-Capture Elements Among Milky Way Disk Stars
The observed chemical diversity of Milky Way stars places important
constraints on Galactic chemical evolution and the mixing processes that
operate within the interstellar medium. Recent works have found that the
chemical diversity of disk stars is low. For example, the APOGEE "chemical
doppelganger rate," or the rate at which random pairs of field stars appear as
chemically similar as stars born together, is high, and the chemical
distributions of APOGEE stars in some Galactic populations are well-described
by two-dimensional models. However, limited attention has been paid to the
heavy elements (Z > 30) in this context. In this work, we probe the potential
for neutron-capture elements to enhance the chemical diversity of stars by
determining their effect on the chemical doppelganger rate. We measure the
doppelganger rate in GALAH DR3, with abundances rederived using The Cannon, and
find that considering the neutron-capture elements decreases the doppelganger
rate from 2.2% to 0.4%, nearly a factor of 6, for stars with -0.1 < [Fe/H] <
0.1. While chemical similarity correlates with similarity in age and dynamics,
including neutron-capture elements does not appear to select stars that are
more similar in these characteristics. Our results highlight that the
neutron-capture elements contain information that is distinct from that of the
lighter elements and thus add at least one dimension to Milky Way abundance
space. This work illustrates the importance of considering the neutron-capture
elements when chemically characterizing stars and motivates ongoing work to
improve their atomic data and measurements in spectroscopic surveys.Comment: 23 pages, 16 figures, 1 table. Submitted to AAS Journals, comments
welcome. Associated catalog of high precision, Cannon-rederived abundances
for GALAH giants to be made publicly available upon acceptance and available
now upon request. See Walsen et al. 2023 for a complementary, high precision,
Cannon-rederived abundance catalog for GALAH solar twin
A gene-tree test of the traditional taxonomy of American deer: the importance of voucher specimens, geographic data, and dense sampling
The taxonomy of American deer has been established almost entirely on the basis of morphological data and without the use of explicit phylogenetic methods; hence, phylogenetic analyses including data for all of the currently recognized species, even if based on a single gene, might improve current understanding of their taxonomy. We tested the monophyly of the morphology-defined genera and species of New World deer (Odocoileini) with phylogenetic analyses of mitochondrial DNA sequences. This is the first such test conducted using extensive geographic and taxonomic sampling. Our results do not support the monophyly of Mazama, Odocoileus, Pudu, M. americana, M. nemorivaga, Od. hemionus, and Od. virginianus. Mazama contains species that belong to other genera. We found a novel sister-taxon relationship between “Mazama” pandora and a clade formed by Od. hemionus columbianus and Od. h. sitkensis, and transfer pandora to Odocoileus. The clade formed by Od. h. columbianus and Od. h. sitkensis may represent a valid species, whereas the remaining subspecies of Od. hemionus appear closer to Od. virginianus. Pudu (Pudu) puda was not found sister to Pudu (Pudella) mephistophiles. If confirmed, this result will prompt the recognition of the monotypic Pudella as a distinct genus. We provide evidence for the existence of an undescribed species now confused with Mazama americana, and identify other instances of cryptic, taxonomically unrecognized species-level diversity among populations here regarded as Mazama temama, “Mazama” nemorivaga, and Hippocamelus antisensis. Noteworthy records that substantially extend the known distributions of M. temama and “M.” gouazoubira are provided, and we unveil a surprising ambiguity regarding the distribution of “M.” nemorivaga, as it is described in the literature. The study of deer of the tribe Odocoileini has been hampered by the paucity of information regarding voucher specimens and the provenance of sequences deposited in GenBank. We pinpoint priorities for future systematic research on the tribe Odocoileini.Eliécer E. Gutiérrez, Kristofer M. Helgen, Molly M. McDonough, Franziska Bauer, Melissa T.R. Hawkins, Luis A. Escobedo-Morales, Bruce D. Patterson, Jesus E. Maldonad
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