Visualization, analysis, and design of COMBO-FISH probes in the grid-based GLOBE 3D genome platform

The genome architecture in cell nuclei plays an important role in modern microscopy for the monitoring of medical diagnosis and therapy since changes of function and dynamics of genes are interlinked with changing geometrical parameters. The planning of corresponding diagnostic experiments and their imaging is a complex and often interactive IT intensive challenge and thus makes high-performance grids a necessity. To detect genetic changes we recently developed a new form of fluorescence in situ hybridization (FISH) - COMBinatorial Oligonucleotide FISH (COMBO-FISH) - which labels small nucleotide sequences clustering at a desired genomic location. To achieve a unique hybridization spot other side clusters have to be excluded. Therefore, we have designed an interactive pipeline using the grid-based GLOBE 3D Genome Viewer and Platform to design and display different labelling variants of candidate probe sets. Thus, we have created a grid-based virtual "paper" tool for easy interactive calculation, analysis, management, and representation for COMBO-FISH probe design with many an advantage: Since all the calculations and analysis run in a grid, one can instantly and with great visual ease locate duplications of gene subsequences to guide the elimination of side clustering sequences during the probe design process, as well as get at least an impression of the 3D architectural embedding of the respecti

Superdeformation in 91Tc

A high-spin rotational band with 11 γ-ray transitions has been observed in 91Tc. The dynamical moment of inertia as well the transition quadrupole moment of 8.1-1.4/+1.9 eb measured for this band show the characteristics of a superdeformed band. However, the shape is more elongated than in the neighbouring A = 80-90 superdeformed nuclei. Theoretical interpretations of the band within the cranked Strutinsky approach based on two different Woods-Saxon potential parameterisations are presented. Even though an unambiguous configuration assignment proved difficult, both calculations indicate a larger deformation and at least three additional high-N intruder orbitals occupied compared to the lighter SD nuclei

Estrutura das exportações e crescimento econômico: uma análise empírica, 1985-2003 Export structure and economic growth: an empirical analysis, 1985-2003

O artigo discute empiricamente a ideia de que a estrutura das exportações seja determinante para o crescimento econômico. A influência da estrutura das exportações sobre a taxa de crescimento é abordada no contexto de um modelo com restrição externa. Para testar essa relação, as exportações foram divididas em dois grupos: a) dinâmicas sob uma perspectiva schumpeteriana (que incluem setores de alta tecnologia) e b) dinâmicas sob uma perspectiva keynesiana (que incluem setores para os quais o crescimento da demanda internacional é superior à média). A hipótese-chave é que, quando os países nos quais os setores com eficiências keynesiana e schumpeteriana têm maior peso nas exportações, esses atingem taxas mais elevadas de crescimento. Os resultados mostram que os dois tipos de eficiência têm um efeito positivo e significativo, sendo mais forte o impacto da eficiência schumpeteriana.<br>The paper discusses the idea that the quality of exports matters for economic growth. The influence of the structure of exports on the rates of economic growth is discussed within the context of a growth model with external constraints. To test the relationship between exports and growth, exports are divided in two groups: a) dynamic from a Schumpeterian perspective (high-tech sectors) and b) dynamic from a Keynesian perspective (international demand grows at higher rates than the average). The key hypothesis is that countries whose total exports have higher shares of sectors with Keynesian and Schumpeterian efficiency will grow faster. The empirical results are consistent with this hypothesis. In addition, the results suggest that Schumpeterian efficiency tends to have a stronger impact on growth than Keynesian efficiency