Chlorobenzene compounds as possible immuno-disruptor agents

Dichlorobenzenes are lipophilic, depositable, colorless liquids that appear as an exposure factor because they are continuously present in households, but are also used in agriculture in large quantities in e.g. insecticides and fungicides. As there is a constant interaction between the living systems and its environment and the internal organizational stability of biological systems is controlled by homeostasis, these agents may disrupt the homeostasis, therefore it is especially important to study the effect of these compounds on the immune system

Effect of subtoxic dose, extreme low frequency (ELF) electromagnetic field (EMF) treatments on liver enzyme changes in in vivo Turkey model experiments

Natural electromagnetic field background radiation in Earth is 20-30 µT, which is a condition in terrestrial evolution. Today, however, in the technosphere-determined environment, intermittent extreme low-frequency electromagnetic fields are predominant. In the present work, we aim to investigate this topic area by in vivo systematic study of subtoxic and chronic electromagnetic field exposures in a turkey model

Sugar substitute compounds as environmental exposures - aspects from neuroendocrine functions

It is an extremely interesting question to what extent elements of psychic activity (e.g. cognition) in social existence can change by mediating neuroendocrine communication when it is necessarily altered by chemical environmental influences (e.g. nutritional biological agents) through real technosphere exposures. In the processes of learning and memory, biological mechanisms regulated by the neuro-endocrine system appear predominantly, showing a network relationship with essential local system properties. Exposures (dietary supplements) are tested on in vitro models by monitoring the events of neuro-endocrinological communication (hormone secretions, monoamine /adrenaline and serotonine/) and their changes in exposure

Magnesium-dependent atpase as a possibility for the investigation of deponating environmental loads in a hepatocyte model

Chemicals that load the environment can be chlorobenzenes with massive chemical stability. They induce a dose-dependent toxic effect in the cells of affected tissues, and because of their high frequency of occurrence in the food chain, they can be used as expositors in environmental exposure models. In this work, we wanted to investigate the magnesium-dependent ATPase activity of chlorobenzenes in hepatocytes

A fibrocyte model for monitoring environmental chemicals

Human activity affects all elements of the Earth's environment and the system of relationships between them. Chlorobenzenes created during chemicalization are capable of modulating the adaptation potential of biological organisms and because of their high frequency of occurrence in the food chain, they can be used as expositors in environmental exposure models. It is necessary to develop a biological model system suitable for the investigation of environmental pollutant chemical agents, which indicates changes quickly and easily

Exclusion of the anterior communicating artery with endovascular flow diverters – A possible treatment method of a wide-necked aneurysm

Introduction: We describe a case of a patient with severe subarachnoid hemorrhage from the rupture of difficult-to-treat morphology, a suspected partially thrombosed anterior communicating artery aneurysm. Case presentation: The patient was admitted with World Federation of Neurosurgeons (WFNS) score of 4 and a Fisher grade IV hemorrhage. Angiography demonstrated a wide neck anterior communicating artery aneurysm not suitable for the standard coiling and surgical treatment. On the 10th day after the bleeding, endovascular treatment was performed to exclude the anterior communicating artery from the circulation by implanting flow diverters to A2 to A1 on both sides. On Day 18, a CT scan showed communicating hydrocephalus, and thus the patient was treated with a ventriculoperitoneal shunt. At the four-month follow-up, angiography showed O'Kelly-Marotta grade D aneurysm occlusion, and the patient's modified Rankin score was 0. The patient made a complete recovery. Discussion: Even though this was a rare application of the flow diverter, other treatment approaches, including detachable coil, stent implantation, and surgical clipping were considered less safe and less effective treatment in this case of anterior communicating artery aneurysm. Conclusion: Endovascular exclusion of the anterior communicating artery from the circulation may be a safe and effective treatment approach in cases without significant perforant artery branches where the conventional endovascular treatment is not considered to be applicable. © 2023 The Author