1,612 research outputs found
Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up †
Readout of GEM Detectors Using the Medipix2 CMOS Pixel Chip
We have operated a Medipix2 CMOS readout chip, with amplifying, shaping and
charge discriminating front-end electronics integrated on the pixel-level, as a
highly segmented direct charge collecting anode in a three-stage gas electron
multiplier (Triple-GEM) to detect the ionization from Fe X-rays and
electrons from Ru. The device allows to perform moderate energy
spectroscopy measurements (20 % FWHM at 5.9 keV -rays) using only digital
readout and two discriminator thresholds. Being a truly 2D-detector, it allows
to observe individual clusters of minimum ionizing charged particles in
(70:30) and (70:30) mixtures and to achieve excellent
spatial resolution for position reconstruction of primary clusters down to
, based on the binary centroid determination method.Comment: 18 pages, 14 pictures. submitted to Nuclear Instruments and Methods
in Physics Research
Critical Susceptibility Exponent Measured from Fe/W(110) Bilayers
The critical phase transition in ferromagnetic ultrathin Fe/W(110) films has
been studied using the magnetic ac susceptibility. A statistically objective,
unconstrained fitting of the susceptibility is used to extract values for the
critical exponent (gamma), the critical temperature Tc, the critical amplitude
(chi_o) and the range of temperature that exhibits power-law behaviour. A
fitting algorithm was used to simultaneously minimize the statistical variance
of a power law fit to individual experimental measurements of chi(T). This
avoids systematic errors and generates objective fitting results. An ensemble
of 25 measurements on many different films are analyzed. Those which permit an
extended fitting range in reduced temperature lower than approximately .00475
give an average value gamma=1.76+-0.01. Bilayer films give a weighted average
value of gamma = 1.75+-0.02. These results are in agreement with the
-dimensional Ising exponent gamma= 7/4. Measurements that do not exhibit
power-law scaling as close to Tc (especially films of thickness 1.75ML) show a
value of gamma higher than the Ising value. Several possibilities are
considered to account for this behaviour.Comment: -Submitted to Phys. Rev. B -Revtex4 Format -6 postscript figure
Growth modes of Fe(110) revisited: a contribution of self-assembly to magnetic materials
We have revisited the epitaxial growth modes of Fe on W(110) and Mo(110), and
propose an overview or our contribution to the field. We show that the
Stranski-Krastanov growth mode, recognized for a long time in these systems, is
in fact characterized by a bimodal distribution of islands for growth
temperature in the range 250-700°C. We observe firstly compact islands
whose shape is determined by Wulff-Kaischev's theorem, secondly thin and flat
islands that display a preferred height, ie independant from nominal thickness
and deposition procedure (1.4nm for Mo, and 5.5nm for W on the average). We
used this effect to fabricate self-organized arrays of nanometers-thick stripes
by step decoration. Self-assembled nano-ties are also obtained for nucleation
of the flat islands on Mo at fairly high temperature, ie 800°C. Finally,
using interfacial layers and solid solutions we separate two effects on the
preferred height, first that of the interfacial energy, second that of the
continuously-varying lattice parameter of the growth surface.Comment: 49 pages. Invited topical review for J. Phys.: Condens. Matte
Adjuvant low-dose interferon α2a with or without dacarbazine compared with surgery alone: a prospective-randomized phase III DeCOG trial in melanoma patients with regional lymph node metastasis
Background: More than half of patients with melanoma that has spread to regional lymph nodes develop recurrent disease within the first 3 years after surgery. The aim of the study was to improve disease-free survival (DFS) and overall survival (OS) with interferon (IFN) α2a with or without dacarbazine (DTIC) compared with observation alone. Patients and methods: A total of 444 patients from 42 centers of the German Dermatologic Cooperative Oncology Group who had received a complete lymph node dissection for pathologically proven regional node involvement were randomized to receive either 3 MU s.c. of IFNα2a three times a week for 2 years (Arm A) or combined treatment with same doses of IFNα2a plus DTIC 850 mg/m2 every 4-8 weeks for 2 years (Arm B) or to observation alone (Arm C). Treatment was discontinued at first sign of relapse. Results: A total of 441 patients were eligible for intention-to-treat analysis. Kaplan-Meier 4-year OS rate of those who had received IFNα2a was 59%. For those with surgery alone, survival was 42% (A versus C, P = 0.0045). No improvement of survival was found for the combined treatment Arm B with 45% survival rate (B versus C, P = 0.76). Similarly, DFS rates showed significant benefit for Arm A, and not for Arm B. Multivariate Cox model confirmed that Arm A has an impact on OS (P = 0.005) but not Arm B (P = 0.34). Conclusions: 3 MU interferon α2a given s.c. three times a week for 2 years significantly improved OS and DFS in patients with melanoma that had spread to the regional lymph nodes. Interestingly, the addition of DTIC reversed the beneficial effect of adjuvant interferon α2a therap
Facilitating the registration of biocontrol organisms, plant extracts and semiochemicals in Europe
The legal regulation of plant protection products (Dir. 91/414/ EEC) is a bottleneck in the market introduction of new microbial biocontrol agents, plant extracts and pheromones. In contrast, invertebrate biocontrol agents (“beneficials”) are not registered at EU level.
The EU-funded project REBECA suggested improvements to accelerate the regulation process and make it more cost-effective, without compromises to the level of safety. Representatives of all stakeholder groups participated in the REBECA workshops. The EU Commission and Member States are encouraged to improve the registration of biocontrol organisms, plant extracts and semiochemicals at EU and/or national level.
The full proposals can be found at www.rebeca-net.de
First principles calculation of structural and magnetic properties for Fe monolayers and bilayers on W(110)
Structure optimizations were performed for 1 and 2 monolayers (ML) of Fe on a
5 ML W(110) substrate employing the all-electron full-potential linearized
augmented plane-wave (FP-LAPW) method. The magnetic moments were also obtained
for the converged and optimized structures. We find significant contractions
( 10 %) for both the Fe-W and the neighboring Fe-Fe interlayer spacings
compared to the corresponding bulk W-W and Fe-Fe interlayer spacings. Compared
to the Fe bcc bulk moment of 2.2 , the magnetic moment for the surface
layer of Fe is enhanced (i) by 15% to 2.54 for 1 ML Fe/5 ML W(110), and
(ii) by 29% to 2.84 for 2 ML Fe/5 ML W(110). The inner Fe layer for 2
ML Fe/5 ML W(110) has a bulk-like moment of 2.3 . These results agree
well with previous experimental data
First observation of excited states in 173Hg
The neutron-deficient nucleus 173Hg has been studied following
fusion-evaporation reactions. The observation of gamma rays decaying from
excited states are reported for the first time and a tentative level scheme is
proposed. The proposed level scheme is discussed within the context of the
systematics of neighbouring neutron-deficient Hg nuclei. In addition to the
gamma-ray spectroscopy, the alpha decay of this nucleus has been measured
yielding superior precision to earlier measurements.Comment: 5 pages, 4 figure
Temozolomide plus pegylated interferon alfa-2b as first-line treatment for stage IV melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group (DeCOG)
Background: Combination of temozolomide (TMZ) with nonpegylated interferon alfa is associated with increased efficacy in terms of response rates compared with monotherapy. A multicenter phase II study was carried out to assess the activity and toxicity of TMZ plus pegylated interferon alfa-2b (peg-IFNα-2b), hypothesizing improved efficacy due to modified pharmacokinetic properties of the novel interferon (IFN) formulation. Patients and methods: In all, 124 patients with stage IV melanoma without prior chemotherapy and no cerebral metastases were treated with 100 μg peg-IFNα-2b s.c. per week and oral TMZ 200 mg/m2 (days 1-5, every 28 days). Primary study end point was objective response, and secondary end points were overall and progression-free survival (PFS) and safety. Results: In all, 116 patients were assessable for response: 2 (1.7%) had a complete response and 19 (16.4%) a partial response (overall response rate 18.1%). Of total, 25.0% achieved disease stabilization and 56.9% progressed. Overall survival was 9.4 months; PFS was 2.8 months. Grade 3/4 thrombocytopenia occurred in 20.7% and grade 3/4 leukopenia in 23.3%. Conclusions: The efficacy of TMZ plus peg-IFNα-2b in this large phase II study is moderate and comparable to published results of the combination of TMZ with non-peg-IFN. Likewise, the safety profile of peg-IFNα-2b seems to be similar to non-peg-IFN when combined with TM
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