Phase I study of gemcitabine using a once every 2 weeks schedule.

Gemcitabine (2',2'-difluorodeoxycytidine) is a novel nucleoside analogue. As part of a series of studies to determine the maximum tolerated dose (MTD) of gemcitabine and the most appropriate schedule, a two-centre phase I study of gemcitabine was undertaken in patients with advanced refractory solid tumours using a once every 2 weeks schedule. Fifty-two patients were entered into the study at 14 different dose levels (40-5700 mg m-2). Weekly evaluations for toxicity were performed and the MTD for this once every 2 weeks schedule was 5700 mg m-2. The dose-limiting toxicity was myelosuppression, with neutropenia being most significant. Other toxicities were nausea, vomiting, fever and asthenia. One minor response was seen in a heavily pretreated breast cancer patient treated at 1200 mg m-2. Preclinical studies suggest that the efficacy of gemcitabine is more schedule than dose related, and it is concluded that this is not the most appropriate dosing schedule for gemcitabine. However, this study demonstrates the safety profile of gemcitabine, as doses over fourfold greater than that recommended for the weekly schedule of 1000 mg m-2 could be tolerated

SOSIALISASI DAN PELATIHAN ECOBRICK SEBAGAI UPAYA MENGURANGI SAMPAH PLASTIK DI KELURAHAN BATU GAJAH

Sampah plastik merupakan salah satu dari sekian banyak faktor penyumbang kerusakan ekosistem yang terus digunakan dalam kehidupan sehari-hari sehingga permasalahan sampah plastik selalu menjadi permasalahan yang sulit diatasi. Tujuan dilaksanakannya kegiatan ini adalah untuk meningkatkan pemahaman masyarakat terkait pengelolaan sampah plastik secara kreatif melalui metode ecobrick. Melalui sosialisasi dan pelatihan pengolahan sampah dengan metode ecobrick, anak muda di Kelurahan Batu Gajah tergerak untuk turut  mengimplementasikannya pada kehidupan bermasyarakat sehingga dapat berdampak positif, baik untuk kebersihan lingkungan maupun untuk membantu dalam meningkatkan perkembangan ekonomi kreatif di Kelurahan Batu Gaja

‘It used to be brutal, now it’s an art’:changing negotiations of violence and masculinity in British karate

In most western (and indeed eastern) cultures, fighting is seen as an ultimate symbol of masculinity – an embodied display of dominance, control and violence (Bourdieu, 2001). As a space legitimising and praising performances of mimetic violence (Dunning, 1999), combat sports provide an arena where the virtues of dominance and power at the heart of conceptions of orthodox masculinity (Anderson, 2010 ) or hegemonic masculinity (Connell, 2005) can be symbolically presented by men through bodily displays of strength, physical aggression, and the taking and overcoming of pain (Bourdieu, 2001; Messner, 1990; Wacquant, 2004). Yet, over the last twenty years the focus of karate in Britain has been perceived to shift from aggressive acts of 'hitting hard' to developing and displaying controlled, acrobatic and technically precise movements. Drawn from a nine-month ethnography and 7 semi-structured interviews, this chapter explores how British male karate practitioners re/negotiate ideas of masculinity and embodiments of a masculine identity in the context of karate’s changing emphasis on, and practices of, 'violence'. This paper suggests that a 'civilising' shift (Elias and Dunning, 1986) in the competition rules increases in women’s participation in karate with men, and subsequent negotiations of mimetic violence, complicate the use of violence as a symbol of praised masculine identity within British karate . A praised masculine identity is crafted by carefully blending traits conventional deemed feminine such as technical precision, elegance and agility alongside displays of strength and dominance. Such performances challenge conceptions of an orthodox sporting masculinity and notions of hierarchical gender distinction

A Cross-Cultural Exploration of Masculinity and Relationships in Men From Turkey, Norway, and the United States

Masculinity ideology is the endorsement of a set of culturally based male role norms that influences gender-related attitudes, beliefs, and behaviors. However, masculinity research has been criticized for not being inclusive enough of different cultures. This study explored the cultural and relational components of masculinity by comparing 564 Turkish, Norwegian, and U.S. men\u27s endorsement of masculinity ideology and examining the associations between masculinity ideology and interpersonal attitudes and behavioral competencies with romantic partners and work colleagues separately for the three groups of men. Norwegian men had significantly lower scores on a measure of masculinity ideology than both Turkish and U.S. men. Canonical correlation analyses revealed that all three groups of men had significant associations between male role norms and interpersonal relationship variables, but the patterns of association differed by country. Generally, endorsement of traditional male role norms was associated with poorer interpersonal competencies for men in all three countries, although the associations were much stronger for the Norwegian sample. Implications, limitations, and directions for future research are discussed. © The Author(s) 2013