In this Day and Age: An Empirical Gyrochronology Relation for Partially and Fully Convective Single Field Stars

Gyrochronology, the field of age-dating stars using mainly their rotation periods and masses, is ideal for inferring the ages of individual main-sequence stars. However, due to the lack of physical understanding of the complex magnetic fields in stars, gyrochronology relies heavily on empirical calibrations that require consistent and reliable stellar age measurements across a wide range of periods and masses. In this paper, we obtain a sample of consistent ages using the gyro-kinematic age-dating method, a technique to calculate the kinematics ages of stars. Using a Gaussian Process model conditioned on ages from this sample (~ 1 - 14 Gyr) and known clusters (0.67 - 3.8 Gyr), we calibrate the first empirical gyrochronology relation that is capable of inferring ages for single, main-sequence stars between 0.67 Gyr to 14 Gyr. Cross-validating and testing results suggest our model can infer cluster and asteroseismic ages with an average uncertainty of just over 1 Gyr. With this model, we obtain gyrochronology ages for ~ 100,000 stars within 1.5 kpc of the Sun with period measurements from Kepler and ZTF, and 384 unique planet host stars.Comment: Submitted to AJ. Missing citations welcom

Bridging the gap -- the disappearance of the intermediate period gap for fully convective stars, uncovered by new ZTF rotation periods

The intermediate period gap, discovered by Kepler, is an observed dearth of stellar rotation periods in the temperature-period diagram at $\sim$ 20 days for G dwarfs and up to $\sim$ 30 days for early-M dwarfs. However, because Kepler mainly targeted solar-like stars, there is a lack of measured periods for M dwarfs, especially those at the fully convective limit. Therefore it is unclear if the intermediate period gap exists for mid- to late-M dwarfs. Here, we present a period catalog containing 40,553 rotation periods (9,535 periods $>$ 10 days), measured using the Zwicky Transient Facility (ZTF). To measure these periods, we developed a simple pipeline that improves directly on the ZTF archival light curves and reduces the photometric scatter by 26%, on average. This new catalog spans a range of stellar temperatures that connect samples from Kepler with MEarth, a ground-based time domain survey of bright M-dwarfs, and reveals that the intermediate period gap closes at the theoretically predicted location of the fully convective boundary ($G_{\rm BP} - G_{\rm RP} \sim 2.45$ mag). This result supports the hypothesis that the gap is caused by core-envelope interactions. Using gyro-kinematic ages, we also find a potential rapid spin-down of stars across this period gap

Abrupt decrease of the population of a tiger beetle species, Cylindela elisae (Carabidae, Cicindelinae), in Tottori Sand Dunes, Honshu, Japan in 2017.

鳥取市鳥取砂丘オアシス周辺に営巣するエリザハンミョウの集団の保全に向けて2015 年から本種の成虫が発生する夏季に標識再捕法により当地での発生個体数を調査している。すでに結果を報告している2016 年までの調査に引き続き2017 年も同様の調査をおこなった。エリザハンミョウの成虫の消長は過去2年よりも早めに進行し，成虫は6月中旬に出現，7月中にはほぼ消失した。この間にマークできた総個体数は112（2015 年は304，2016 年は270）とこの3 年間で最も少なく， Jolly-Seber 法による個体数推定値はもっとも多かった調査日（6 月27 日）でわずか153 であった（2015 年は2,300個体，2016 年は1,460 個体）。この個体数は個体群を健全に維持するために必要とされる最小集団サイズ（MVP）として従来言われてきていた500（個体数変動の大きい動植物では10,000）を大幅に下回っており，危険な状態である。2017 年におけるエリザハンミョウ成虫の早期の出現と消失は2017 年の7 月の高温が，また，個体数の減少にもっとも寄与した要因としては2017 年の4～6 月の少雨が考えられる。 / As a consecutive series of surveys of the population size of a tiger beetle species, Cylindera elisae (Motschulsky 1859) at a site so-called“ Oasis” in the Tottori Sand Dunes, Tottori City, started in 2015 (Tsurusaki et al. 2016, 2017), we estimated population size of the same population of the same species also in 2017 by using a mark-recapture method. A total of 112 adults of C. elisae were individually marked during the summer in 2017 (304 and 270 adults in 2015 and 2016 surveys, respectively). The highest number of adults of C. elisae estimated by the Jolly-Seber method was only 153 recorded on 27 June 2017. This population size is much smaller than 500 which was the number formerly often said as the minimum viable population (MVP), to say nothing of 10,000 as the MVP for univoltine insects whose population size tend to be variable every year. 　It is probable that high air temperature of July in 2017 brought early emergence and disappearance of C. elisae in 2017. It is also likely that drought at “Oasis” area due to extremely low amount of precipitation from April to June in 2017 was the main factor for the marked decrease of population of this species in 2017. Some measure should be taken for the recovery of this population

Predictors of Survival in Patients With Ischemic Stroke and Active Cancer: A Prospective, Multicenter, Observational Study

BACKGROUND: Limited data exist on the prognostic factors for patients with ischemic stroke and active cancer. METHODS AND RESULTS: We conducted a prospective, multicenter, observational study in Japan, including patients with acute ischemic stroke and active cancer, to investigate the prognostic factors. We followed up the patients for 1 year after stroke onset. The patients were divided into 2 groups according to cryptogenic stroke and known causes (small-vessel occlusion, large-artery atherosclerosis, cardioembolism, and other determined cause), and survival was compared. The hazard ratios (HRs) and 95% CIs for mortality were calculated using Cox regression models. We identified 135 eligible patients (39% women; median age, 75 years). Of these patients, 51% had distant metastasis. A total of 65 (48%) and 70 (52%) patients had cryptogenic stroke and known causes, respectively. Patients with cryptogenic stroke had significantly shorter survival than those with known causes (HR [95% CI], 3.11 [1.82–5.32]). The multivariable Cox regression analysis revealed that distant metastasis, plasma D-dimer levels, venous thromboembolism (either deep venous thrombosis or pulmonary embolism) complications at stroke onset were independent predictors of mortality after adjusting for potential confounders. Cryptogenic stroke was associated with prognosis in univariable analysis but was not significant in multivariable analysis. The plasma D-dimer levels stratified the prognosis of patients with ischemic stroke and active cancer. CONCLUSIONS: The prognosis of patients with acute ischemic stroke and active cancer varied considerably depending on stroke mechanism, distant metastasis, and coagulation abnormalities. The present study confirmed that coagulation abnormalities were crucial in determining the prognosis of such patients.Gon Y., Sakaguchi M., Yamagami H., et al. Predictors of Survival in Patients With Ischemic Stroke and Active Cancer: A Prospective, Multicenter, Observational Study. Journal of the American Heart Association 12, e029618 (2023); https://doi.org/10.1161/JAHA.123.029618

TESS Giants Transiting Giants. I.: A Noninflated Hot Jupiter Orbiting a Massive Subgiant

While the population of confirmed exoplanets continues to grow, the sample of confirmed transiting planets around evolved stars is still limited. We present the discovery and confirmation of a hot Jupiter orbiting TOI-2184 (TIC 176956893), a massive evolved subgiant (M ∗ = 1.53 ± 0.12 M o˙, R ∗ = 2.90 ± 0.14 R o˙) in the Transiting Exoplanet Survey Satellite (TESS) Southern Continuous Viewing Zone. The planet was flagged as a false positive by the TESS Quick-Look Pipeline due to periodic systematics introducing a spurious depth difference between even and odd transits. Using a new pipeline to remove background scattered light in TESS Full Frame Image data, we combine space-based TESS photometry, ground-based photometry, and ground-based radial velocity measurements to report a planet radius of R p = 1.017 ± 0.051 R J and mass of M p = 0.65 ± 0.16 M J . For a planet so close to its star, the mass and radius of TOI-2184b are unusually well matched to those of Jupiter. We find that the radius of TOI-2184b is smaller than theoretically predicted based on its mass and incident flux, providing a valuable new constraint on the timescale of post-main-sequence planet inflation. The discovery of TOI-2184b demonstrates the feasibility of detecting planets around faint (TESS magnitude > 12) post-main-sequence stars and suggests that many more similar systems are waiting to be detected in the TESS FFIs, whose confirmation may elucidate the final stages of planetary system evolution

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects