Thiosilicate der Lanthanide : Synthesen, Kristallstrukturen und magnetische Eigenschaften

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Properties and Application of High-manganese TWIP-steels in Sheet Metal Forming

AbstractWithin this work uniaxial tensile tests have been performed with high-manganese TWIP-steel and different dual-phase steels to determine mechanical properties. The transfer of the results form uniaxial tensile tests to multi-axial stresses has been made with deep drawing experiments to describe and assess deep and stretch formability of the analysed materials. Forming limits of materials are demonstrated by forming limit diagrams. FE-simulation systems have been applied to predict deep drawing and spring-back behaviour of high-manganese TWIP in comparison to dual-phase steels. The simulation results are discussed between the different materials

Диагностика релятивистских электронных пучков по угловому распределению когерентного дифракционного излучения

Современные лазерно-плазменные ускорители позволяют получать и ускорять электронные сгустки субпикосекундной длительности, для которых отсутствуют средства диагностики требуемой точности. Распространенный метод измерения длительности электронных сгустков основан на использовании стрик – камеры, точность которого не превышает 1 мм. Использование метода, основанного на спектрально-угловых измерения когерентного переходного излучения, позволяет улучшить точность. Использование КДИ для этой цели обеспечивает неинвазивный характер диагностики. В ходе выполнения ВКР были исследованы возможности использования когерентного дифракционного излучения (КДИ) от щелевой мишени со смещением для измерения длины электронного сгустка.Modern laser-plasma accelerators make it possible to obtain and accelerate electron bunches of subpicosecond duration, for which there are no diagnostic tools of the required accuracy. A common method for measuring the duration of electron bunches is based on the use of a streak camera, the accuracy of which does not exceed 1 mm. The use of a method based on spectral-angular measurements of coherent transition radiation makes it possible to improve the accuracy. The use of CDR for this purpose provides a non-invasive diagnostic character. In the course of graduation project , the possibilities of using coherent diffraction radiation (CDR) from an offset slit target to measure the length of an electron bunch were investigated

A feasibility trial of skin surface motion-gated stereotactic body radiotherapy for treatment of upper abdominal or lower thoracic targets using a novel O-ring gantry

BACKGROUND AND PURPOSE: A novel O-ring gantry can deliver stereotactic body radiation therapy (SBRT) with artificial intelligence-facilitated, CT-guided online plan adaptation. It gates mobile targets by optically monitoring skin surface motion. However, this gating solution has not been clinically validated. We conducted a trial to evaluate the feasibility of optical skin surface-guided gating for patients with mobile upper abdominal or lower thoracic malignancies treated with SBRT on this platform (NCT05030454). MATERIALS AND METHODS: Ten patients who were prescribed SBRT to a thoracic or abdominal target and were capable of breath-hold for at least 17 s enrolled. They received SBRT in five fractions with breath-hold technique and optical skin surface motion monitored-gating with a ± 2 mm tolerance. Online plan adaptation was left to the discretion of the daily treating physician. The primary endpoint was defined as successful completion of \u3e 75 % of attempted fractions. Exploratory endpoints included local control and acute grade ≥ 3 toxicity rates after three months. For adapted fractions the contouring, planning, quality assurance, and treatment delivery times were recorded. RESULTS: Forty-seven of 51 SBRT fractions (92 %) were successfully gated at breath-hold by optical skin surface motion monitoring. The tumor centroid position during breath-hold varied by a mean of approximately 2 mm. Sixty-three percent of fractions were adapted online with a median total treatment time of 78.5 min. After three months no local recurrences or acute grade ≥ 3 toxicities were observed. CONCLUSIONS: SBRT treatment to mobile targets with surface-monitored gating on a novel O-ring gantry was prospectively validated

A pilot study of same-day MRI-only simulation and treatment with MR-guided adaptive palliative radiotherapy (MAP-RT)

We conducted a prospective pilot study evaluating the feasibility of same day MRI-only simulation and treatment with MRI-guided adaptive palliative radiotherapy (MAP-RT) for urgent palliative indications (NCT#03824366). All (16/16) patients were able to complete 99% of their first on-table attempted fractions, and no grades 3-5 toxicities occurred

Prospective in silico evaluation of cone-beam computed tomography-guided stereotactic adaptive radiation therapy (CT-STAR) for the ablative treatment of ultracentral thoracic disease

PURPOSE: We conducted a prospective, in silico study to evaluate the feasibility of cone-beam computed tomography (CBCT)-guided stereotactic adaptive radiation therapy (CT-STAR) for the treatment of ultracentral thoracic cancers (NCT04008537). We hypothesized that CT-STAR would reduce dose to organs at risk (OARs) compared with nonadaptive stereotactic body radiation therapy (SBRT) while maintaining adequate tumor coverage. METHODS AND MATERIALS: Patients who were already receiving radiation therapy for ultracentral thoracic malignancies underwent 5 additional daily CBCTs on the ETHOS system as part of a prospective imaging study. These were used to simulate CT-STAR, in silico RESULTS: Seven patients were accrued, 6 with intraparenchymal tumors and 1 with a subcarinal lymph node. CT-STAR was feasible in 34 of 35 simulated fractions. In total, 32 dose constraint violations occurred when the P CONCLUSIONS: CT-STAR widened the dosimetric therapeutic index of ultracentral thorax SBRT compared with nonadaptive SBRT. A phase 1 protocol is underway to evaluate the safety of this paradigm for patients with ultracentral early-stage NSCLC

Urine cell-free DNA multi-omics to detect MRD and predict survival in bladder cancer patients

Circulating tumor DNA (ctDNA) sensitivity remains subpar for molecular residual disease (MRD) detection in bladder cancer patients. To remedy this problem, we focused on the biofluid most proximal to the disease, urine, and analyzed urine tumor DNA in 74 localized bladder cancer patients. We integrated ultra-low-pass whole genome sequencing (ULP-WGS) with urine cancer personalized profiling by deep sequencing (uCAPP-Seq) to achieve sensitive MRD detection and predict overall survival. Variant allele frequency, inferred tumor mutational burden, and copy number-derived tumor fraction levels in urine cell-free DNA (cfDNA) significantly predicted pathologic complete response status, far better than plasma ctDNA was able to. A random forest model incorporating these urine cfDNA-derived factors with leave-one-out cross-validation was 87% sensitive for predicting residual disease in reference to gold-standard surgical pathology. Both progression-free survival (HR = 3.00, p = 0.01) and overall survival (HR = 4.81, p = 0.009) were dramatically worse by Kaplan-Meier analysis for patients predicted by the model to have MRD, which was corroborated by Cox regression analysis. Additional survival analyses performed on muscle-invasive, neoadjuvant chemotherapy, and held-out validation subgroups corroborated these findings. In summary, we profiled urine samples from 74 patients with localized bladder cancer and used urine cfDNA multi-omics to detect MRD sensitively and predict survival accurately

Шляхи підвищення ефективності використання виробничих ресурсів сільськогосподарських підприємств

Single-phase polycrystalline samples and single crystals of the complex boride phases Ti8Fe3Ru18B8 and Ti7Fe4Ru18B8 have been synthesized by arc melting the elements. The phases were characterized by powder and single-crystal X-ray diffraction as well as energy-dispersive X-ray analysis. They are new substitutional variants of the Zn11Rh18B8 structure type, space group P4/mbm (no. 127). The particularity of their crystal structure lies in the simultaneous presence of dumbbells which form ladders of magnetically active iron atoms along the [001] direction and two additional mixed iron/titanium chains occupying Wyckoff sites 4h and 2b. The ladder substructure is ca. 3.0 Å from the two chains at the 4h, which creates the sequence chain–ladder–chain, establishing a new structural and magnetic motif, the scaffold. The other chain (at 2b) is separated by at least 6.5 Å from this scaffold. According to magnetization measurements, Ti8Fe3Ru18B8 and Ti7Fe4Ru18B8 order ferrimagnetically below 210 and 220 K, respectively, with the latter having much higher magnetic moments than the former. However, the magnetic moment observed for Ti8Fe3Ru18B8 is unexpectedly smaller than the recently reported Ti9Fe2Ru18B8 ferromagnet. The variation of the magnetic moments observed in these new phases can be adequately understood by assuming a ferrimagnetic ordering involving the three different iron sites. Furthermore, the recorded hysteresis loops indicate a semihard magnetic behavior for the two phases. The highest Hc value (28.6 kA/m), measured for Ti7Fe4Ru18B8, lies just at the border of those of hard magnetic materials