High-coherence ultra-broadband bidirectional dual-comb fiber laser

Dual-comb spectroscopy has emerged as an attractive spectroscopic tool for high-speed, high-resolution, and high-sensitivity broadband spectroscopy. It exhibits certain advantages when compared to the conventional Fourier-transform spectroscopy. However, the high cost of the conventional system, which is based on two mode-locked lasers and a complex servo system with a common single-frequency laser, limits the applicability of the dual-comb spectroscopy system. In this study, we overcame this problem with a bidirectional dual-comb fiber laser that generates two high-coherence ultra-broadband frequency combs with slightly different repetition rates (frep). The two direct outputs from the single-laser cavity displayed broad spectra of > 50 nm; moreover, an excessively small difference in the repetition rate (< 1.5 Hz) was achieved with high relative stability, owing to passive common-mode noise cancellation. With this slight difference in the repetition rate, the applicable optical spectral bandwidth in dual-comb spectroscopy could attain ~479 THz (~3,888 nm). In addition, we successfully generated high-coherence ultra-broadband frequency combs via nonlinear spectral broadening and detected high signal-to-noise-ratio carrier–envelope offset frequency (fCEO) beat signals using the self-referencing technique. We also demonstrated the high relative stability between the two fCEO beat signals and tunability. To our knowledge, this is the first demonstration of fCEO detection and frequency measurement using a self-referencing technique for a dual-comb fiber laser. The developed high-coherence ultra-broadband dual-comb fiber laser with capability of fCEO detection is likely to be a highly effective tool in practical, high-sensitivity, ultra-broadband applications

All-polarization-maintaining, polarization-multiplexed, dual-comb fiber laser with a nonlinear amplifying loop mirror

We developed an all-polarization-maintaining, polarization-multiplexed, dual-comb fiber laser with a nonlinear amplifying loop mirror (NALM) mode-locking mechanism. Owing to the use of the slow and fast axes of a polarization-maintaining fiber (PMF), the dual-frequency combs with slightly different repetition rates from the single-laser cavity are generated at the same center wavelength without extra-cavity nonlinear spectral broadening. The narrow relative beat note between the two frequency combs is obtained with a full-width-at-half-maximum of ~1 kHz in the optical frequency domain. The two frequency combs have high relative stability and mutual coherence owing to passive common-mode noise cancellation

Immunohistochemical Examination on the Distribution of Cells Expressed Lymphatic Endothelial Marker Podoplanin and LYVE-1 in the Mouse Tongue Tissue

The clinical study for lingual disease requires the detailed investigation of the lingual lymphatic network and lymphatic marker-positive cells. Recently, it has been reported that several tissue cells and leukocytes express lymphatic markers, LYVE-1 and podoplanin. This study was aimed to clarify the lingual distribution of cells expressing LYVE-1 and podoplanin. In the mouse tongue, podoplanin is expressed in nerve sheaths, lingual gland myoepithelial cells, and lymphatic vessels. LYVE-1 is expressed in the macrophage marker Mac-1-positive cells as well as lymphatic vessels, while factor-VIII was detected in only blood endothelial cells. α-SMA was detected in vascular smooth muscle and myoepithelial cells. Therefore, identification of lymphatic vessels in lingual glands, the combination of LYVE-1 and factor-VIII, or LYVE-1 and Mac-1 is useful because myoepithelial cells express podoplanin and α-SMA. The immunostaining of factor-VIII on lymphatic vessels was masked by the immunostaining to LYVE-1 or podoplanin because lymphatic vessels express factor-VIII to a far lesser extent than blood vessels. Therefore, except for the salivary glands, the combination of podoplanin and α-SMA, or factor-VIII is useful to identify lymphatic vessels and blood vessels with smooth muscle, or blood capillaries

Acetylation Unleashes Protein Demons of Dementia

Aberrant posttranslational modifications of proteins can impair synaptic plasticity and may render neurons vulnerable to degeneration during aging. In this issue of Neuron, Min et al. show that acetylation of the amino acid lysine in the microtubule-associated protein tau prevents its ubiquitin-mediated degradation, resulting in “tau tangles” similar to those of dementias. Other recent studies suggest that lysine hyperacetylation contributes to the accumulation of amyloid β-peptide in Alzheimer's disease and to impaired cognitive function resulting from a trophic factor deficit

Seaweed intake and blood pressure levels in healthy pre-school Japanese children

<p>Abstract</p> <p>Background</p> <p>Few studies have examined whether dietary factors might affect blood pressure in children. We purposed to investigate whether seaweed intake is associated with blood pressure level among Japanese preschool children.</p> <p>Methods</p> <p>The design of the study was cross-sectional and it was conducted in autumn 2006. Subjects were healthy preschoolers aged 3-6 years in Aichi, Japan. Blood pressure and pulse were measured once by an automated sphygmomanometer, which uses oscillometric methods. Dietary data, including seaweed intake, were assessed using 3-day dietary records covering 2 consecutive weekdays and 1 weekend day. Of a total of 533 children, 459 (86.1 percent) agreed to be enrolled in our study. Finally, blood pressure measurement, complete dietary records and parent-reported height and weight were obtained for 223 boys and 194 girls.</p> <p>Results</p> <p>When we examined Spearman's correlation coefficients, seaweed intake was significantly negatively related to systolic blood pressure in girls (<it>P </it>= 0.008). In the one-way analysis of covariance for blood pressure and pulse after adjustments for age and BMI, the boys with the lowest, middle and highest tertiles of seaweed intake had diastolic blood pressure readings of 62.8, 59.3 and 59.6 mmHg, respectively (<it>P </it>= 0.11, trend <it>P </it>= 0.038). Girls with higher seaweed intake had significantly lower systolic blood pressure readings (102.4, 99.2 and 96.9 mmHg for girls with the lowest, middle and highest tertiles of seaweed intake, respectively; <it>P </it>= 0.037, trend <it>P </it>= 0.030).</p> <p>Conclusion</p> <p>Our study showed that seaweed intake was negatively related to diastolic blood pressure in boys and to systolic blood pressure in girls. This suggests that seaweed might have beneficial effects on blood pressure among children.</p

A dehydrated space-weathered skin cloaking the hydrated interior of Ryugu

Without a protective atmosphere, space-exposed surfaces of airless Solar System bodies gradually experience an alteration in composition, structure and optical properties through a collective process called space weathering. The return of samples from near-Earth asteroid (162173) Ryugu by Hayabusa2 provides the first opportunity for laboratory study of space-weathering signatures on the most abundant type of inner solar system body: a C-type asteroid, composed of materials largely unchanged since the formation of the Solar System. Weathered Ryugu grains show areas of surface amorphization and partial melting of phyllosilicates, in which reduction from Fe3+ to Fe2+ and dehydration developed. Space weathering probably contributed to dehydration by dehydroxylation of Ryugu surface phyllosilicates that had already lost interlayer water molecules and to weakening of the 2.7 µm hydroxyl (–OH) band in reflectance spectra. For C-type asteroids in general, this indicates that a weak 2.7 µm band can signify space-weathering-induced surface dehydration, rather than bulk volatile loss

A Novel <i>NKX2-5</i> Variant in a Child with Left Ventricular Noncompaction, Atrial Septal Defect, Atrioventricular Conduction Disorder, and Syncope

The NKX2-5 gene encodes a transcription factor and is actively involved in heart formation and development. A pediatric case with its variant and left ventricular noncompaction (LVNC) has not been reported. A 12-year-old girl with a history of a surgery for atrial septal detect was referred because of syncope during exercise. The electrocardiogram showed atrioventricular block, and the echocardiogram revealed prominent trabeculations in the left ventricular wall, suggesting LVNC. A novel heterozygous variant in the NKX2-5 gene (NM_004387.1: c.255_256delCT, p.Phe86fs) was identified. NKX2-5 variants should be considered in cases with LVNC, congenital heart disease, arrhythmia, and syncope to prevent sudden cardiac death

Non-thermal Tomonaga-Luttinger liquid eventually emerging from hot electrons in the quantum Hall regime

Dynamics of integrable systems, such as Tomonaga-Luttinger (TL) liquids, is deterministic, and the absence of stochastic thermalization processes provides unique characteristics, such as long-lived non-thermal metastable states with many conserved quantities. Here, we show such non-thermal states can emerge even when the TL liquid is excited with extremely high-energy hot electrons in chiral quantum-Hall edge channels. This demonstrates the robustness of the integrable model against the excitation energy. Crossover from the single-particle hot electrons to the many-body TL liquid is investigated by using on-chip detectors with a quantum point contact and a quantum dot. The charge dynamics can be understood with a single-particle picture only for hot electrons. The resulting electron-hole plasma in the TL liquid shows a non-thermal metastable state, in which warm and cold electrons coexist without further thermalization. The multi-temperature constituents are attractive for transporting information with conserved quantities along the channels.Comment: 13 pages, 12 figure