46 research outputs found
Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media
Chronic otitis media (OM) is common in Down syndrome (DS), but underlying aetiology is unclear. We analysed the entire available mouse resource of partial trisomy models of DS looking for histological evidence of chronic middle-ear inflammation. We found a highly penetrant OM in the Dp(16)1Yey mouse, which carries a complete trisomy of MMU16. No OM was found in the Dp(17)1Yey mouse or the Dp(10)1Yey mouse, suggesting disease loci are located only on MMU16. The Ts1Cje, Ts1RhR, Ts2Yah, and Ts65Dn trisomies and the transchomosomic Tc1 mouse did not develop OM. On the basis of these findings, we propose a two-locus model for chronic middle-ear inflammation in DS, based upon epistasis of the regions of HSA21 not in trisomy in the Tc1 mouse. We also conclude that environmental factors likely play an important role in disease onset
Wechselwirkung der Schmelze mit Fels Experimentelle Bestimmung wichtiger Stoffwerte. Abschlussbericht
With 14 refs., 3 tabs., 50 figs.Copy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
Theoretische Aufstellung der Energiebilanzen, Bilanzgrenze RDB-Wand (RS 72b) und Bilanzgrenze Containment-Wand (RS 72a) fuer DWR und SWR Abschlussbericht
Fuer eine DWR- und SWR-Standardanlage wurden die thermodynamischen Zustaende im Reaktordruckbehaelter (RDB) und im Containment bei einem hypothetischen Kernschmelzunfall mit ingenieurmaessigen Mitteln analysiert. (orig.)The thermohydraulics in the pressure vessel and in the containment during a hypothetical reactor melt down accident were analyzed for a PWR and a BWR. (orig.)SIGLEAvailable from TIB Hannover: D.Dt.F.QN1(10,2) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Bewertung einiger Massnahmen zur Reduktion der Unfallfolgen der Freisetzungskategorie II Abschlussbericht
With 12 refs., 5 tabs., 14 figs.SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Untersuchungen zur Containmentintegritaet bei Kernschmelzen unter hohem Primaerkreisinnendruck Abschlussbericht
TIB: RN 7995 (1984,003) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman