Antioxidant Activity of Leaves and Fruits of Iranian Conifers

Cupressus semipervirens var. horizontalis, Cupressus semipervirens var. semipervirens, Cupressus semipervirens cv. Cereifeormis, Juniperus communis subsp. hemisphaerica, Juniperus excelsa subsp. excelsa, Juniperus excelsa subsp. polycarpos, Juniperus foetidissima, Juniperus oblonga, Juniperus sabina, Platycladus orientalis and Taxus baccata are Iranian conifers. The antioxidant activity of leaves and fruits of these 11 different taxons were evaluated. The leaves of both male and female, and fruits of these plants were collected from different areas of the country. Methanol extract of leaves and fruits of these taxons were prepared. Antioxidant activity of each extracts was measured using two different tests of the ferric thiocyanate method and thiobarbituric acid. Results indicated that the methanol extracts of leaves, of male and female, and fruits of all these species (27 samples) possessed antioxidant activity when tested with both methods. The antioxidant activity was then compared with those of α-tocopherol (a natural antioxidant) and butylated hydroxytoluene (a synthetic antioxidant). Methanol extract of fruits of C. semipervirens cv. Cereifeormis showed the highest antioxidant activity while the methanol extract of leaves of C. semipervirens var. semipervirens possessed the lowest antioxidant activity. However, our finding showed that most of the tested extracts were showing strong antioxidant activity even higher than α-tocopherol

Morphometric and meristic study of Garra rufa populations in Tigris and Persian Gulf Basins

This study was conducted to determine morphometric and meristic characteristics of Garra rufa in 13 stations of Tigris and Persian Gulf basins. We caught 310 specimens during the year 2007-2008 using electro-shocker and sachok. Univariate analysis of variance (ANOVA) and principal component analysis were conducted and the ANOVA revealed significant differences in 28 morphometric and 9 meristic factors (P<0.05). Factor analysis showed that G. rufa of thirteen stations had 48.855% changes in 3 factors of the first morphometric characters (pectoral fin length, ventral fin length, depth of anal fin) and 71/611% changes in 3 factors of the first meristic characters (lateral line scales , circum peduncle scales, predorsal scales). Plotting the first and second principal component morphometric and meristic characters showed that the Mond River population was separated from the others but the other populations were overlapping with each other in the characteristics studied

Effects of energy drinks on blood pressure, heart rate, and electrocardiographic parameters: An experimental study on healthy young adults

Objective: To evaluate the effects of the consumption of energy drinks on cardiovascular parameters in a group of healthy young individuals. Methods: In a quasi-experimental study, 44 healthy adult participants aged between 15 and 30 years were evaluated. The blood pressure (BP) as well as electrocardiographic indices, including heart rate (HR), PR interval, QRS duration, corrected QT (QTc) interval, and ST-T changes were recorded before consumption of a caffeine-containing energy drink and at the specific time points over a 4-h test duration. Results: We found statistically significant HR decline (p=0.004) and more frequent ST-T changes (p=0.004) after the participants consumed the energy drink. However, readings for systolic BP (p=0.44), diastolic BP (p=0.26), PR interval (p=0.449), QRS duration (p=0.235), and QTc interval (p=0.953) showed no significant change post-consumption. Conclusion: In conclusion, we demonstrated that the consumption of energy drinks could contribute to HR decline and ST-T change in healthy young adults. © 2016 by Turkish Society of Cardiology

Fluoxetin upregulates connexin 43 expression in astrocyte

Introduction: Recent studies have shown that astrocytes play major roles in normal and disease condition of the central nervous system including multiple sclerosis (MS). Molecular target therapy studies in MS have revealed that connexin-43 (Cx43) and Aquaporin-4 (AQP4) contents of astrocytes undergo expression alteration. Fluoxetine had some effects in MS patients unrelated to its known antidepressant effects. Some of fluoxetine effects were attributed to its capability of cAMP signaling pathway stimulation. This study aimed to investigate possible acute effects of fluoxetine on Cx43 and AQP4 expression in astrocyte. Methods: Astrocytoma cells were treated for 24 hours with fluoxetine (10 and 20 μg/ml) with or without adenyl cyclase (AC) and protein kinase A (PKA) inhibition. Cx43 expression at both mRNA and protein levels and AQP4 expression at mRNA level were evaluated. Results: Acquired results showed that fluoxetine with and without AC and PKA inhibition resulted in Cx43 up-regulation both in mRNA and protein levels, whereas AQP4 expression have not changed. Discussion: In conclusion, data showed that fluoxetine alone and in the absence of serotonin acutely up-regulated Cx43 expression in astrocytes that can be assumed in molecular target therapy of MS patients. It seems that cAMP involvement in fluoxetine effects need more researches

Propionate functions as a feeding state-dependent regulatory metabolite to counter proinflammatory signaling linked to nutrient load and obesity.

The authors thank Drs. Antonio Murgia and Ben McNally of the University of Cambridge Biochemistry Department for their contributions to metabolomics and lipidomic data processing. They thank and acknowledge the assistance of the National Heart, Lung, and Blood Institute DNA Sequencing and Genomics Core in performing the RNA library sequencing and the National Heart, Lung, and Blood Institute Flow Cytometry Core for performing the flow cytometry.Peer reviewe

Selective β2 adrenergic agonist increases Cx43 and miR-451 expression via cAMP-Epac

It has been demonstrated that connexin 43 (Cx43) and microRNAs have significant roles in glioma. Cyclic adenosine monophosphate (cAMP) is suggested to be a regulator of connexins and microRNAs. However, it remains elusive whether cAMP and exchange protein directly activated by cAMP (Epac2), have a regulatory effect on Cx43 and microRNA-451 (miR-451) in astrocytoma cells. We treated 1321N1 astrocytoma cells with a selective β2 adrenergic agonist and a selective Epac activator with and without adenyl cyclase and protein kinase A inhibition. Cx43 and miR-451 expression were measured. Next, we evaluated the effect of miR-451 overexpression on Cx43 expression. Cell proliferation was measured using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results demonstrated that cAMPE-pac2 increased Cx43 and miR-451 expression. However, the alteration of miR-451 expression required a higher dose of drugs. Overexpression of miR-451 had no significant effect on Cx43 expression. The MTT assay showed that cAMP-Epac stimulation and miR-451 overexpression had a synergic inhibitory effect on cell proliferation. These findings may expand our understanding of the molecular biology of glioma and provide new potential therapeutic targets

Results of SemTab 2022

SemTab 2022 was the fourth edition of the Semantic Web Challenge on Tabular Data to Knowledge Graph Matching, successfully collocated with the 21st International Semantic Web Conference (ISWC) and the 17th Ontology Matching (OM) Workshop. SemTab provides a common framework to conduct a systematic evaluation of state-of-the-art systems. In this paper, we give an overview of the 2022’s edition of the challenge and summarize the results

Results of SemTab 2023

SemTab 2023 was the fifth edition of the Semantic Web Challenge on Tabular Data to Knowledge Graph Matching, collocated with the 22nd International Semantic Web Conference (ISWC) and the 18th Ontology Matching (OM) Workshop. SemTab provides a framework to conduct a systematic evaluation of state-of-the-art semantic table interpretation systems. In this paper, we give an overview of the 2023 edition of the challenge and summarize the results

Results of SemTab 2021

SemTab 2021 was the third edition of the Semantic Web Challenge on Tabular Data to Knowledge Graph Matching, successfully collocated with the 20th International Semantic Web Conference (ISWC) and the 16th Ontology Matching (OM) Workshop. SemTab provides a common framework to conduct a systematic evaluation of state-of-the-art systems