Proof of concept of diffuse optical tomography using time-of-flight range imaging cameras

Diffuse optical tomography is an optical technique to create 3-dimensional images of the inside of highly scattering material. Research groups around the world have been developing imaging systems using various source-detector arrangements to determine optical properties of biological tissue with a focus on medical applications. In this paper we investigate whether a range imaging camera can be used as a detector array. We used time-of-flight range imaging cameras instead of the conventional source-detector array used by others. The results provided in this paper show reconstructed images of absorption and reduced scattering of an object submerged in a tissue simulating phantom. Using the ranging camera XZ422 Demonstrator and the NIRFAST software package, we reconstructed 2D images of a 6 mm metal rod submerged in the centre of a 5 cm deep tank filled with 1% IntralipidTM. We have shown for the first time that range imaging cameras can replace the traditional detectors in diffuse optical tomography

Hedging Diffusion Processes by Local Risk-Minimisation with Applications to Index Tracking

The solution to the problem of hedging contingent claims by local risk-minimisation has been considered in detail in Follmer and Sondermann (1986), Follmer and Schweizer (1991) and Schweizer (1991). However, given a stochastic process Xt and tau1 tau2, the strategy that is locally risk-minimising for Xtau1 is in general not locally risk-minimising for Xtau2. In the case of diffusion processes, this paper considers the problem of determining a strategy that is simultaneously locally risk-minimising for Xtau for all tau. That is, a strategy that is locally risk-minimising for the entire process Xt. The necessary and sufficient conditions under which this is possible are obtained, and applied to the problem of index tracking. In particular, a close connection between the local risk-minimising and the tracking error variance minimising strategies for index tracking is established, and leads to a simple criterion for the selection of optimal set of assets from which to form a tracker portfolio, as well as a value-at-risk type measure for the set of assets used.minimal martingale measure; local risk-minimisation; hedging; incomplete market; index tracking; portfolio selection

Intending to be ethical: An examination of consumer choice in sweatshop avoidance

While much research in ethical consumption has focused on contexts such as food, this research explores ethical consumer decision-making in the context of intention to avoid sweatshop apparel. This research seeks to deepen the Theory of Planned Behavior with respect to the motivation and volitional stages underlying behavior. The findings of the research, based on 794 consumers, are novel and support an enriched framework which reveals that the role of attitude, subjective norm and perceived behavioral control are mediated by desire, intention and plan. The findings have implications for research seeking to address the ‘intention-behavior’ gap

Successful retrieval of competing spatial environments in humans involves hippocampal pattern separation mechanisms.

The rodent hippocampus represents different spatial environments distinctly via changes in the pattern of "place cell" firing. It remains unclear, though, how spatial remapping in rodents relates more generally to human memory. Here participants retrieved four virtual reality environments with repeating or novel landmarks and configurations during high-resolution functional magnetic resonance imaging (fMRI). Both neural decoding performance and neural pattern similarity measures revealed environment-specific hippocampal neural codes. Conversely, an interfering spatial environment did not elicit neural codes specific to that environment, with neural activity patterns instead resembling those of competing environments, an effect linked to lower retrieval performance. We find that orthogonalized neural patterns accompany successful disambiguation of spatial environments while erroneous reinstatement of competing patterns characterized interference errors. These results provide the first evidence for environment-specific neural codes in the human hippocampus, suggesting that pattern separation/completion mechanisms play an important role in how we successfully retrieve memories

On entropy, specific heat, susceptibility and Rushbrooke inequality in percolation

We investigate percolation, a probabilistic model for continuous phase transition (CPT), on square and weighted planar stochastic lattices. In its thermal counterpart, entropy is minimally low where order parameter (OP) is maximally high and vice versa. Besides, specific heat, OP and susceptibility exhibit power-law when approaching the critical point and the corresponding critical exponents $\alpha, \beta, \gamma$ respectably obey the Rushbrooke inequality (RI) $\alpha+2\beta+\gamma\geq 2$. Their analogues in percolation, however, remain elusive. We define entropy, specific heat and redefine susceptibility for percolation and show that they behave exactly in the same way as their thermal counterpart. We also show that RI holds for both the lattices albeit they belong to different universality classes.Comment: 5 pages, 3 captioned figures, to appear as a Rapid Communication in Physical Review E, 201

Generation of Lamprey Monoclonal Antibodies (Lampribodies) Using the Phage Display System.

The variable lymphocyte receptors (VLRs) consist of leucine rich repeats (LRRs) and comprise the humoral antibodies produced by lampreys and hagfishes. The diversity of the molecules is generated by stepwise genomic rearrangements of LRR cassettes dispersed throughout the VLRB locus. Previously, target-specific monovalent VLRB antibodies were isolated from sea lamprey larvae after immunization with model antigens. Further, the cloned VLR cDNAs from activated lamprey leukocytes were transfected into human cell lines or yeast to select best binders. Here, we expand on the overall utility of the VLRB technology by introducing it into a filamentous phage display system. We first tested the efficacy of isolating phage into which known VLRB molecules were cloned after a series of dilutions. These experiments showed that targeted VLRB clones could easily be recovered even after extensive dilutions (1 to 109). We further utilized the system to isolate target-specific "lampribodies" from phage display libraries from immunized animals and observed an amplification of binders with relative high affinities by competitive binding. The lampribodies can be individually purified and ostensibly utilized for applications for which conventional monoclonal antibodies are employed