Severe cytomegalovirus gastritis during natalizumab-mediated immunosuppression

We report a 35-year-old female receiving natalizumab as monotherapy for multiple sclerosis who subsequently developed severe cytomegalovirus gastritis. As cytomegalovirus gastritis has not been previously described during natalizumab treatment, we discuss the biological plausibility of this potential association and avenues for further study

The Need For Judicial Activism Acceptance Speech

Honorable President, Dean of the Shepard Broad Law Center, members of the faculty, respected students, distinguished guests, ladies and gentlemen

An Invariant Dual-beam Snowflake Antenna for Future 5G Communications

A broadband snowflake antenna for future 5G and millimeter-wave communications is presented. The proposed antenna has a size of 8 × 5 mm 2 . The antenna consists of a central hexagon surrounded by a series of symmetrically placed smaller hexagons around it, resulting in broadband characteristics. The impedance bandwidth of the proposed antenna ranges from 25.284-29.252 GHz. The antenna has a gain of 3.12 dBi at 28 GHz and is more than 98% efficient. A distinct feature of the proposed antenna is its dual-beam radiation pattern. The two beams remain fixed at ±50° even if the frequency is varied with in its operating band. The proposed antenna is modelled on thin Rogers substrate which makes it very useful for future 5G smart phones

Multiband split-ring resonator based planar inverted-F antenna for 5G applications

5G, the fifth generation of wireless communications, is focusing on multiple frequency bands, such as 6GHz, 10GHz, 15GHz, 28GHz, and 38GHz, to achieve high data rates up to 10 Gbps or more.The industry demands multiband antennas to cover these distant frequency bands, which is a task much more challenging. In this paper, we have designed a novel multiband split-ring resonator (SRR) based planar inverted-F antenna (PIFA) for 5G applications. It is composed of a PIFA, an inverted-L parasitic element, a rectangular shaped parasitic element, and a split-ring resonator (SRR) etched on the top plate of the PIFA.The basic PIFA structure resonates at 6GHz. An addition of a rectangular shaped parasitic element produces a resonance at 15GHz. The introduction of a split-ring resonator produces a band notch at 8GHz, and a resonance at 10GHz, while the insertion of an inverted-L shaped parasitic element further enhances the impedance bandwidth in the 10GHz band. The frequency bands covered, each with more than 1GHz impedance bandwidth, are 6GHz (5–7GHz), 10GHz (9–10.8GHz), and 15GHz (14-15GHz), expected for inclusion in next-generation wireless communications, that is, 5G. The design is simulated using Ansys Electromagnetic Suite 17 simulation software package.The simulated and the measured results are compared and analyzed which are generally in good agreement

Impact of Topical Nepafenac on Macular Thickness after Phacoemulsification with Intraocular Lens Implantation in Patients without Diabetic Retinopathy

PURPOSE:  To study the effect of post-operative Non-Steroidal Anti-inflammatory (NSAID) eye drops on macular thickness in patients without diabetic retinopathy measured by Optical Coherence Tomography (OCT) STUDY DESIGN: Quasi experimental study PLACE & DURATION OF STUDY:  removed for blind review METHODOLOGY: Diabetic patients without retinopathy who required cataract surgery for visual rehabilitation were included in study. They were than divided into two groups. Group A included patients who received routine steroid+antibiotic post-operative drops while Group B comprised of patients who received nepafenac (0.1%) eye drops eight hourly in addition to routine post-operative eye drops. All patients underwent standard phacoemulsification and intraocular lens implantation followed by use of NSAID eye drops for a month. OCT measurements were done pre-operatively, 7 and 28 days post operatively. RESULTS: Comparison of central macular thickness between groups was significant at (Pre & 7 day post op) and insignificant at (7th day & 28th day post op) and (Pre & 28th day post op) i.e. 0.043, 0.834 and 0.084 respectively. However, difference of mean central macular thickness was significant at all follow-up periods i.e.0.003, 0.006, and 0.000 CONCLUSION: Post-operative NSAID in diabetic patients without retinopathy leads to a significant decrease in macular thickness as compared to controls after cataract surgery. KEY WORDS: Phacoemulsification, Optical Coherence Tomography, Non-steroidal Anti-Inflammatory Agent

Pseudomonas aeruginosa Cell Wall Polysaccharide-Iron Oxide Nanoparticle Augments the Formation of Biofilm by the Bacterium

Pseudomonas aeruginosa is very ubiquitous microorganism which is a member of the normal microbial flora in human. The bacterium forms biofilm that is responsible for many persistent and chronic infections. P. aeruginosa biofilm formation is mediated by two soluble lectins, LecA (PA-IL) and LecB (PAIIL) that are essential extracellular virulence factor of P. aeruginosa. In this study bacteria isolated from direct biopsy samples of colorectal cancer (CRC) were used. Iron oxide nanoparticles (IONP) were prepared by coprecipitation method and subsequently coated with Pseudomonas aeruginosa polysaccharide using the principles of electrostatic interaction. The Fourier transform infrared spectroscopy (FTIR) and scanning probe microscope (SPM) analyses confirmed the successful coating of polysaccharide on the surface of iron oxide nanoparticles. The preparation appeared to have 1649 cm-1 (CONH2) and 1543 cm-1 (N-H) band. Particle size for polysaccharide coated iron oxide increased from 85.09 nm for naked iron oxide nanoparticles to 107.20 nm. Bacterial polysaccharide coated iron oxide nanoparticles was used to inhibite Pseudomoas aeruginosa biofilm on saliva coated 96-well polystyrene.It was seen that exposure of cells to polysaccharide coated iron oxide showed increased biofilm formation on optimally coated saliva on polystyrene plates.The highest augmentation was recorded in a concentration of 100mg/ml and in saliva of Lewis group Lea+ and approaching (75%) p˃0.05 and the lowest augmentation was achieved in a concentration of 1mg/ml and approached (5%) p=1.4×10-3, Lea-b- secretor gave (5%) augmentation p=2.6×10-3 while Lea-b- secretor saliva coat showed (15%) augmentation p=0.05 compared with naked iron oxide nanoparticles.Percentage augmentation of polysaccharide coated iron oxide nanoparticles in concentration of 100mg/ml, 10mg/ml and 0.1mg/ml was non significant p˃0.05 except for Leb saliva used in concentration of 0.1mg/ml that was highly significant (44.5%) augmentation p=3.3×10-3in compared with iron oxide nanoparticles. In 0.01 mg/ml polysaccharide-iron oxide nanoparticle concentration augmentation reached (5.9%) p=0.03 for Lea-b-non secretor while Leb saliva (46%) augmentation p=0.03 in addition Lea gave (15%) augmentation and Lea-b- secretor showed (26.7%) augmentation p˃0.05. This imply Lewis molecules determinants and bacterial lectin interaction in biofilm formation. Lectin are involved in biofilm formation. Keywords: key words, polysaccharide-iron oxide, nanoparticles, Pseudomonas aeruginosa biofilm