A prospective study correlating fluid balance and outcome in critically ill patients

Background: Fluid administration can be lifesaving as fluid accumulation after initial resuscitation and stabilization of hemodynamics can lead to avoidable adverse effects and less favorable outcomes.Objective: The aim of the work was to evaluate whether even fluid balance in comparison to negative or even fluid status is correlated with increased morbidity and mortality rates in critically ill patients.Patients and Methods: An observational prospective study was done on 145 patients older than eighteen years, admitted to the general intensive care (Medical & Surgical ICU) units in Helwan University Hospitals and Ain Shams University Hospitals during the period from November 2020 till May 2021.Results: One hundred twenty-four patients (85.5%) who survived, having the median cumulative fluid balance of -110ml (IQR-2.1 – 2.2L) after four days following randomization while the median cumulative fluid balance of the 21 patients (14.5%) who didn’t survive was 3800 ml (IQR 1.7-5.2L), after four days of ICU admission. Fluid balance more than 1.2 liters per day in our study had higher ICU complications: Increased risk of AKI, longer ICU and hospital stays, mechanical ventilation and fluid balance was an independent factor associated with increased mortality.Conclusion: It could be concluded that negative fluid balance for 4 days in critically ill patients was associated with less length of stay in the general ICU, and less mechanical ventilation duration, while positive fluid balance, leads to higher mechanical ventilation duration, vasopressors requirements, and significantly associated with higher mortality

Different spectrophotometric methods manipulating ratio spectra for the assay of hydrocortisone acetate and clioquinol in their topical preparation

Simple and precise spectrophotometric methods for quantitative assay of a mixture of hydrocortisone acetate (HCA) and clioquinol (CL) were developed and validated through different mathematical manipulation pathways. The developed methods utilized ratio spectra for resolving binary mixtures including absorbance subtraction, ratio subtraction coupled with spectrum subtraction, constant multiplication, constant value, and derivative ratio. The proposed methods were proved to be specific by analysing the laboratory-prepared mixtures and were applied for the assay of topical preparation successfully. The methods were validated using ICH guidelines where accuracy, repeatability and intermediate precision were within the acceptable limits. The linearity range was found to be 2-22 for HCA and 1.5-7 µg/mL for CL in all proposed methods and 2-7 µg/mL for HCA and CL in absorbance subtraction method through using a unified regression equation. The findings were statistically evaluated with respect to the official and reported methods, demonstrating that there was no significant difference

Efficacy of nano-hydroxyapatite coating on osseointegration of early loaded dental implants

Background and Objectives:  The success rates of dental implants have been reported as a challenge, especially for early loading in the posterior maxilla area. The surfaces of dental implants are generally modified in an attempt to improve osseointegration. In which Unitite implants with Nano hydroxyapatite coating affect the healing process acceleration, high hydrophilicity, increased bone formation (BIC - Bone Implant Contact ), and the quality improvement of the new bone formed (BAFO - Bone Area Fraction Occupancy), keeping the original implant microtopography. This study aimed to evaluate the efficacy of Nano hydroxyapatite coating osseointegration of early loaded dental implants in the posterior maxilla. Patients and Methods: A clinical trial was carried out on ten patients need  twelve  implants with early loading   were treated in the oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University ;  A root-form implant is the most frequently used type of dental implant today. The basis for dental implants is osseointegration, the HAnano® coating associated with its microtopography generate an increase in the titanium surface energy, making the implant highly hydrophilic, which guarantees the presence of blood and its components in the healing chamber