Investigation of amplidyne position and rate-controlled power drives

This thesis document was issued under the authority of another institution, not NPS. At the time it was written, a copy was added to the NPS Library collection for reasons not now known. It has been included in the digital archive for its historical value to NPS. Not believed to be a CIVINS (Civilian Institutions) title.http://www.archive.org/details/investigationofa00haslU.S. Navy (U.S.N.) authors

A comparison of primary and secondary relevance judgements for real-life topics

The notion of relevance is fundamental to the field of Information Retrieval. Within the field a generally accepted conception of relevance as inherently subjective has emerged, with an individual’s assessment of relevance influenced by numerous contextual factors. In this paper we present a user study that examines in detail the differences between primary and secondary assessors on a set of “real-world” topics which were gathered specifically for the work. By gathering topics which are representative of the staff and students at a major university, at a particular point in time, we aim to explore differences between primary and secondary relevance judgements for real-life search tasks. Findings suggest that while secondary assessors may find the assessment task challenging in various ways (they generally possess less interest and knowledge in secondary topics and take longer to assess documents), agreement between primary and secondary assessors is high

Analisis Perbandingan Penentuan Laba Komersial dan Laba Fiskal Pada PT. Lima Rachmat Sejahtera

Penelitian ini bertujuan untuk menganalisa penentuan laba fiskal PT. LIMA RACHMAT SEJAHTERA dan menganalisa penyebab perbedaan penentuan laba komersial dan laba fiskal pada PT. LIMA RACHMAT SEJAHTERA. Penelitian ini menggunakan penelitian deskriptif komparatif. Deskriptif yaitu menjelaskan secara detail tentang perlakuan akuntansi yang berpengaruh dalam penyajian laporan keuangan dan perlakuan pajak terhadap pendapatan dan beban yang boleh dan tidak boleh dikurangkan. Komparatif yaitu membandingkan laba menurut Standar Akuntansi Keuangan dengan laba menurut Undang-Undang Perpajakan No 36 Tahun 2008. Kesimpulan dari penelitian ini yaitu PT. LIMA RACHMAT SEJAHTERA masih belum tepat dalam menentukan laba fiskal dikarenakan masih kurang tepatnya koreksi fiskal atas akun pendapatan jasa managemen fee beban asuransi kendaraan bermotor, beban pemeliharaan dan perbaikan kendaraan, beban kendaraan dinas lainnya, beban majalah dan literatur, dan beban amortisasi pra operasi karena tidak sesuai dengan ketentuan Undang-Undang Perpajakan. Analisis penyebab timbulnya perbedaan penentuan laba komersial dan laba fiskal PT. LIMA RACHMAT SEJAHTERA yaitu perbedaan dalam hal pengakuan pendapatan dan beban menurut Standar Akuntansi Keuangan dan menurut Undang-Undang Perpajakan. Perbedaan tersebut dikarenakan adanya koreksi fiskal beda waktu yang terdapat pada beban penyusutan gedung. Sedangkan perbedaan dikarenakan adanya koreksi fiskal beda tetap terdapat pada pendapatan bunga bank, pendapatan sewa, beban tunjangan jamsostek, beban THR dan bonus, beban tunjangan lainnya, beban asuransi kendaraan bermotor, beban pemeliharaan dan perbaikan kendaraan, beban kendaraan dinas lainnya, beban entertainment, beban pengobatan, beban amortisasi pra operasi, beban pajak PPh Pasal 4 ayat 2, beban adm bank, beban provisi dan adm kredit, dan beban operasional kantor lainnya

Long-Term Clinical and Multimodal Imaging Findings in Patients with Disseminated Mycobacterium Chimaera Infection

BACKGROUND To analyze long-term ophthalmic clinical and multimodal imaging findings of disseminated Mycobacterium (M.) chimaera infection after cardiothoracic surgery among the Swiss Cohort. METHODS Systemic and multimodal ophthalmic imaging and clinical findings including rate of recurrence were reviewed and correlated to a previously proposed classification system of choroidal lesions and classification of ocular disease. MAIN OUTCOMES MEASURES long-term clinical and multimodal ocular imaging findings of M. chimaera. RESULTS Twelve patients suffering from systemic infection from M. chimaera were included. Mean age at the first ophthalmic examination was 59 years (range from 48 to 66 years). Mean duration of the follow-up was 22.63 ± 17.8 months. All patients presented with bilateral chorioretinal lesions at baseline; 5 patients had additional signs, including optic disc swelling (2), choroidal neovascularization (1), retinal neovascularization (1) and cilioretinal vascular occlusion (1). Four recurrence events after discontinuation or adjustment of the antibiotic treatment were observed. Progressive choroiditis was seen in 5 patients under treatment, 4 of them deceased. CONCLUSIONS Expertise from ophthalmologists is not only relevant but also critical for the assessment of the adverse drug effect of antimycobacterial treatment along with monitoring therapeutic response and identifying recurrences

Neutrophil Extracellular Trap Induced Dendritic Cell Activation Leads to Th1 Polarization in Type 1 Diabetes

Neutrophils releasing neutrophil extracellular traps (NETs) infiltrate the pancreas prior to type 1 diabetes (T1D) onset; however, the precise nature of their contribution to disease remains poorly defined. To examine how NETs affect immune functions in T1D, we investigated NET composition and their effect on dendritic cells (DCs) and T lymphocytes in T1D children. We showed that T1D patient NET composition differs substantially from that of healthy donors and that the presence of T1D-NETs in a mixed peripheral blood mononuclear cell culture caused a strong shift toward IFNγ-producing T lymphocytes, mediated through activation of innate immunity cells in T1D samples. Importantly, in a monocyte-derived DC (moDC) culture, NETs induced cytokine production, phenotypic change and IFNγ-producing T cells only in samples from T1D patients but not in those from healthy donors. RNA-seq analysis revealed that T1D-NETs presence causes TGFβ downregulation and IFNα upregulation and creates pro-T1D signature in healthy moDCs

Cyclic vomiting syndrome: Pathophysiology, comorbidities, and future research directions

Cyclic vomiting syndrome (CVS) is characterized by severe episodic emesis in adults and children. Cannabinoid hyperemesis syndrome is an increasingly recognized CVS‐like illness that has been associated with chronic cannabis use. There are significant gaps in our understanding of the pathophysiology, clinical features, comorbidities, and effective management options of CVS. Recommendations for treating CVS are based on limited clinical data, as no placebo‐controlled, randomized trials have yet been conducted. Diseases associated with CVS, including migraine, mitochondrial disorders, autonomic dysfunction, and psychiatric comorbidities, provide clues about pathophysiologic mechanisms and suggest potential therapies. We review our current understanding of CVS and propose future research directions with the aim of developing effective therapy. Establishing a multicenter, standardized registry of CVS patients could drive research on multiple fronts including developing CVS‐specific outcome measures to broaden our understanding of clinical profiles, to serve as treatment end points in clinical trials, and to provide a platform for patient recruitment for randomized clinical trials. Such a robust database would also facilitate conduct of research that aims to determine the underlying pathophysiological mechanisms and genetic basis for CVS, as well as identifying potential biomarkers for the disorder. Soliciting government and industry support is crucial to establishing the necessary infrastructure and achieving these goals. Patient advocacy groups such as the Cyclic Vomiting Syndrome Association (CVSA), which partner with clinicians and researchers to disseminate new information, to promote ongoing interactions between patients, their families, clinicians, investigators, to support ongoing CVS research and education, must be an integral part of this endeavor.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149751/1/nmo13607.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149751/2/nmo13607_am.pd

Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association

The increasing recognition of cyclic vomiting syndrome (CVS) in adults prompted the development of these evidence‐based guidelines on the management of CVS in adults, which was sponsored by the American Neurogastroenterology and Motility Society (ANMS) and the Cyclic Vomiting Syndrome Association (CVSA). GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) framework was used and a professional librarian performed the literature search. The expert committee included the President of the CVSA who brought a patient perspective into the deliberations. The committee makes recommendations for the prophylaxis of CVS, treatment of acute attacks, diagnosis, and overall management of CVS. The committee strongly  recommends that adults with moderate‐to‐severe CVS receive a tricyclic antidepressant (TCA), such as amitriptyline, as a first‐line prophylactic medication and receive topiramate or aprepitant as alternate prophylactic medications. Zonisamide or levetiracetam and mitochondrial supplements (Coenzyme Q10, L‐carnitine, and riboflavin) are conditionally recommended as alternate prophylactic medications, either alone or concurrently with other prophylactic medications. For acute attacks, the committee conditionally recommends using serotonin antagonists, such as ondansetron, and/or triptans, such as sumatriptan or aprepitant to abort symptoms. Emergency department treatment is best achieved with the use of an individualized treatment protocol and shared with the care team (example provided). The committee recommended screening and treatment for comorbid conditions such as anxiety, depression, migraine headache, autonomic dysfunction, sleep disorders, and substance use with referral to appropriate allied health services as indicated. Techniques like meditation, relaxation, and biofeedback may be offered as complementary therapy to improve overall well‐being and patient care outcomes.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149730/1/nmo13604.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149730/2/nmo13604_am.pd