The Aflatoxin M1 level and Antibiotic Residues in raw milk supplied across the city of Bojnurd in 2016

Background: Milk is considered as one of the most complete foods, consumption of raw milk contained with aflatoxin M1 and antibiotics has raised consumer concerns. The aim of this study was to determine the level of aflatoxin and antibiotic residues in raw milk in Bojnurd, Khorasan province, Iran. Methods: In this study, 40 samples of raw milk from their distribution centers in the city of Bojnourd, were taken randomly in summer and fall of 2016. Samples were evaluated for aflatoxin and antibiotic residues by ELISA method and Coupons kit respectively. Descriptive statistics including means and standard deviations were used to summarize the data. Data was analyzed with SPSS 19. Results: According to the results, no residues of antibiotics were found in raw milk and the aflatoxin concentrations were between 5.1 and 65 ng per ml and the levels were lower than the Iran standards in all samples. Conclusion: According to the results, antibiotics residues and aflatoxin M1 levels in raw milk of Bojnoord city are within the acceptable level. However, it is recommended to evaluate these parameters in all seasons

Cannabinoids as a Promising Therapeutic Approach for the Treatment of Glioblastoma Multiforme: A Literature Review

Gliobalstoma multiforme (GBM) or grade 4 astrocytoma is the most malignant form of primary brain tumor. Treatment of glioblastoma is difficult despite of surgery, radiotherapy and chemotherapy. Patients with glioblastoma survive for less than 12 months. Considering to biology function of glioblastoma, researchers have recently offered new therapeutic approaches such as cannabinoid therapy for glioblastoma. Cannabinoids are active compounds of Cannabis sativa that operate in the body similar to endogenous canabinoids –the endocannabinoids- through cell surface receptors. It is interesting that cannabinoids could exert a wide spectrum from antiproliferative effects in condition of the cell culture, animal models of glioblastoma and clinical trials. As a result, Cannabinoids seem to modulate intracellular signaling pathways and the endoplasmic reticulum stress response in glioma cells. Those play antitumoral effects through apoptosis induction and inhibition of glioblastoma angiogenesis. The goal of this study was to discuss cannabinoid therapy and also what cellular mechanisms are involved in the tumoricidal effect of the cannabinoids. In this review article, we will focus on cannabinoids, their receptor dependent functional roles against glioblastoma acccording to growth, angiogenesis, metastasis, and future purposes in exploring new possible therapeutic opportunities