Genetic Diversity of SARS-CoV2 and Environmental Settings: Possible Association with Neurological Disorders

International audienceThe new coronavirus (CoV), called novel coronavirus disease 2019 (COVID-19), belongs to the Coronaviridae family which wasoriginated from the sea market in Wuhan city in China, at the end of the year 2019. COVID-19 and severe acute respiratorysyndrome (SARS) are belonging to the same family (Coronaviridae). The current outbreak of COVID-19 creates public concernand threats all over the world and now it spreads out to more than 250 countries and territories. The researchers and scientists fromall over the world are trying to find out the therapeutic strategies to abate the morbidity and mortality rate of the COVID-19 pandemic. The replication, spreading, and severity of SARS-CoV2 depend on environmental settings. Noteworthy, meteorological parameters are considered as crucial factors that affect respiratory infectious disorders, although the controversial effectof the meteorological parameter is exposed against COVID-19. Besides, COVID-19 accelerates the pathogenesis of the neurological disorders. However, the pathogenic mechanisms between COVID-19 and neurological disorders are still unclear. Hence,this review is focused on the genomics and ecology of SARS-CoV2 and elucidated the effects of climatic factors on theprogression of COVID-19. This review also critically finds out the vulnerability between COVID-19 and neurological disordersbased on the latest research data

COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management

International audienceAt the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective treatment of this newly life-threatening and devastating virus. Therefore, it is crucial to search for alternative methods that alleviate or inhibit the spread of COVID-19. In this review, we try to find out the etiology, epidemiology, symptoms as well as transmissions of this novel virus. We also summarize therapeutic interventions and suggest antiviral treatments, immune-enhancing candidates, general supplements, and CoV specific treatments that control replication and reproduction of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV)