Genetic Diversity of SARS-CoV2 and Environmental Settings: Possible Association with Neurological Disorders

Abstract

International audienceThe new coronavirus (CoV), called novel coronavirus disease 2019 (COVID-19), belongs to the Coronaviridae family which wasoriginated from the sea market in Wuhan city in China, at the end of the year 2019. COVID-19 and severe acute respiratorysyndrome (SARS) are belonging to the same family (Coronaviridae). The current outbreak of COVID-19 creates public concernand threats all over the world and now it spreads out to more than 250 countries and territories. The researchers and scientists fromall over the world are trying to find out the therapeutic strategies to abate the morbidity and mortality rate of the COVID-19 pandemic. The replication, spreading, and severity of SARS-CoV2 depend on environmental settings. Noteworthy, meteorological parameters are considered as crucial factors that affect respiratory infectious disorders, although the controversial effectof the meteorological parameter is exposed against COVID-19. Besides, COVID-19 accelerates the pathogenesis of the neurological disorders. However, the pathogenic mechanisms between COVID-19 and neurological disorders are still unclear. Hence,this review is focused on the genomics and ecology of SARS-CoV2 and elucidated the effects of climatic factors on theprogression of COVID-19. This review also critically finds out the vulnerability between COVID-19 and neurological disordersbased on the latest research data