Insensitive control technology development

THe investigation of two insensitive controller synthesis techniques was reported. The finite dimensional inverse approach produces a time varying insensitive controller and/or parameter identifier by constructing inverse functions derived from a finite number of input output pair relationships. The MD/IM concept relies on the information matrix theory that was developed in the estimation and identification field. The MD/IM synthesis technique is based on the hypothesis that minimizing the information matrix will reduce system identifiability and consequently system sensitivity to uncertain parameters. The controllers designed with both techniques were evaluated on a realistic C-5A aircraft flight control problem. Results indicate that the FDI controller is more suited to trajectory type problems because of its time varying nature. The MD/IM controller performed as well as the top-rated controllers of the initial effort and has direct application to aircraft flight control problems

A Comparative Study of the Magnitude, Frequency and Distribution of Intense Rainfall in the United Kingdom

During the 1960s, a study was made of the magnitude, frequency and distribution of intense rainfall over the UK, employing data from more than 120 daily-read rain gauges covering the period 1911 to 1960. Using the same methodology, that study was recently updated utilizing data for the period 1961 to 2006 for the same gauges, or from those nearby. This paper describes the techniques applied to ensure consistency of data and statistical modelling. It presents a comparison of patterns of extreme rainfalls for the two periods and discusses the changes that have taken place. Most noticeably, increases up to 20% have occurred in the north west of the country and in parts of East Anglia. There have also been changes in other areas, including decreases of the same magnitude over central England. The implications of these changes are considered

Development of primary invasive pneumococcal disease caused by serotype 1 pneumococci is driven by early increased type I interferon response in the lung

The pneumococcus is the world's foremost respiratory pathogen, but the mechanisms allowing this pathogen to proceed from initial asymptomatic colonization to invasive disease are poorly understood. We have examined the early stages of invasive pneumococcal disease (IPD) by comparing host transcriptional responses to an invasive strain and a noninvasive strain of serotype 1 Streptococcus pneumoniae in the mouse lung. While the two strains were present in equal numbers in the lung 6 h after intranasal challenge, only the invasive strain (strain 1861) had invaded the pleural cavity at that time point; this correlated with subsequent development of bacteremia in mice challenged with strain 1861 but not the noninvasive strain (strain 1). Progression beyond the lung was associated with stronger induction of the type I interferon (IFN-I) response in the lung at 6 h. Suppression of the IFN-I response through administration of neutralizing antibody to IFNAR1 (the receptor for type I interferons) led to significantly reduced invasion of the pleural cavity by strain 1861 at 6 h postchallenge. Our data suggest that strong induction of the IFN-I response is a key factor in early progression of invasive serotype 1 strain 1861 beyond the lung during development of IPD

Seafood Safety and Trade

Food Consumption/Nutrition/Food Safety, International Relations/Trade,

Design and preliminary test results at Mach 5 of an axisymmetric slotted sound shield

The basic theory and sound attenuation mechanisms, the design procedures, and preliminary experimental results are presented for a small axisymmetric sound shield for supersonic wind tunnels. The shield consists of an array of small diameter rods aligned nearly parallel to the entrance flow with small gaps between the rods for boundary layer suction. Results show that at the lowest test Reynolds number (based on rod diameter) of 52,000 the noise shield reduced the test section noise by about 60 percent ( or 8 db attenuation) but no attenuation was measured for the higher range of test reynolds numbers from 73,000 to 190,000. These results are below expectations based on data reported elsewhere on a flat sound shield model. The smaller attenuation from the present tests is attributed to insufficient suction at the gaps to prevent feedback of vacuum manifold noise into the shielded test flow and to insufficient suction to prevent transition of the rod boundary layers to turbulent flow at the higher Reynolds numbers. Schlieren photographs of the flow are shown

A phylogeny of birds based on over 1,500 loci collected by target enrichment and high-throughput sequencing

Evolutionary relationships among birds in Neoaves, the clade comprising the vast majority of avian diversity, have vexed systematists due to the ancient, rapid radiation of numerous lineages. We applied a new phylogenomic approach to resolve relationships in Neoaves using target enrichment (sequence capture) and high-throughput sequencing of ultraconserved elements (UCEs) in avian genomes. We collected sequence data from UCE loci for 32 members of Neoaves and one outgroup (chicken) and analyzed data sets that differed in their amount of missing data. An alignment of 1,541 loci that allowed missing data was 87% complete and resulted in a highly resolved phylogeny with broad agreement between the Bayesian and maximum-likelihood (ML) trees. Although results from the 100% complete matrix of 416 UCE loci were similar, the Bayesian and ML trees differed to a greater extent in this analysis, suggesting that increasing from 416 to 1,541 loci led to increased stability and resolution of the tree. Novel results of our study include surprisingly close relationships between phenotypically divergent bird families, such as tropicbirds (Phaethontidae) and the sunbittern (Eurypygidae) as well as between bustards (Otididae) and turacos (Musophagidae). This phylogeny bolsters support for monophyletic waterbird and landbird clades and also strongly supports controversial results from previous studies, including the sister relationship between passerines and parrots and the non-monophyly of raptorial birds in the hawk and falcon families. Although significant challenges remain to fully resolving some of the deep relationships in Neoaves, especially among lineages outside the waterbirds and landbirds, this study suggests that increased data will yield an increasingly resolved avian phylogeny.Comment: 30 pages, 1 table, 4 figures, 1 supplementary table, 3 supplementary figure