6 research outputs found
Whole genome sequencing for the investigation of rare anaemias: challenges and real-world outcomes
Ravulizumab (ALXN1210) versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria: pharmacokinetics and pharmacodynamics observed in two Phase 3 randomized, multicenter studies
RationaleIntracerebral haemorrhage caused Ë3 million deaths worldwide in 2015. Twoâthirds of survivors are left dependent on others. Roughly one third of patients are taking antiplatelet drugs at the time of intracerebral haemorrhage in highâincome countries, and this proportion has been increasing over time. Preâstroke antiplatelet drug use is associated with a 27% relative increase in oneâmonth case fatality compared to patients not using antithrombotic drugs. Platelet transfusion, tranexamic acid, and recombinant activated factor VII do not seem to improve outcome after antiplateletâassociated intracerebral haemorrhage, but desmopressin has seemed promising in nonârandomised pilot studies.ObjectivesWe aim to assess the feasibility of screening, checking the eligibility, approaching, randomising, administering desmopressin or placebo, and completing followâup for patients with antiplateletâassociated intracerebral haemorrhage. DesignWe aim to include 50 patients within 12 hours of spontaneous intracerebral haemorrhage onset, associated with oral antiplatelet drug(s) use in the preceding seven days. Exclusion criteria are: known secondary cause for intracerebral haemorrhage; risk of fluid retention associated with desmopressin; significant hypotension (SBP ConclusionThis is a feasibility trial, which will inform the design of a definitive trial.</div
Le Torrent / P. Delanoë ; P. Harvet ; Léo Carmi. BAMBINO : ("Guaglione") / J. Larue ; Fanciulli. Ah ! les américains / Théodore ; Bazin. Concerto d'automne / Denoncin ; Ithier ; Bargoni ; ArsÚne Hic et son orch. d'empoisonneurs diplÎmés
Titre uniforme : [Bambino]Titre uniforme : [Bambino]BnF-Partenariats, Collection sonore - BelieveContient une table des matiĂšre