24 research outputs found
Asymmetric Michael reaction of diethyl malonate with crotonaldehyde catalyzed by chiral aminocarboxylates, amino alcoholates, and amino phenolates
Asymmetric Michael reaction of diethyl malonate with crotonaldehyde catalyzed by chiral aminocarboxylates, amino alcoholates, and amino phenolates
Asymmetric Michael reaction of diethyl malonate with crotonaldehyde catalyzed by chiral aminocarboxylates, amino alcoholates, and amino phenolates
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms
Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance in JAK2V617F-negative MPN: rs12339666 (JAK2; meta-analysis P=1.27 × 10−10) and rs2201862 (MECOM; meta-analysis P=1.96 × 10−9). Two additional SNPs, rs2736100 (TERT) and rs9376092 (HBS1L/MYB), achieve genome-wide significance when including JAK2V617F-positive cases. rs9376092 has a stronger effect in JAK2V617F-negative cases with CALR and/or MPL mutations (Breslow–Day P=4.5 × 10−7), whereas in JAK2V617F-positive cases rs9376092 associates with essential thrombocythemia (ET) rather than polycythemia vera (allelic χ2 P=7.3 × 10−7). Reduced MYB expression, previously linked to development of an ET-like disease in model systems, associates with rs9376092 in normal myeloid cells. These findings demonstrate that multiple germline variants predispose to MPN and link constitutional differences in MYB expression to disease phenotype
The GAPS Programme at TNG: XXXV. Fundamental properties of transiting exoplanet host stars
Context. Exoplanetary properties strongly depend on stellar properties: to know the planet with accuracy and precision it is necessary to know the star as accurately and precisely as possible. Aims. Our immediate aim is to characterize in a homogeneous and accurate way a sample of 27 transiting planet-hosting stars observed within the Global Architecture of Planetary System program. For the wide visual binary XO-2, we considered both components (N: hosting a transiting planet; S: without a known transiting planet). Our final goal is to widely analyze the sample by deriving several stellar properties, abundances of many elements, kinematic parameters, and discuss them in the context of planetary formation. Methods. We determined the stellar parameters (effective temperature, surface gravity, rotational velocity) and abundances of 26 elements (Li, C, N, O, Na, Mg, Al, Si, S, Ca, Sc, Ti, V, Cr, Fe, Mn, Co, Ni, Cu, Zn, Y, Zr, Ba, La, Nd, Eu). Our study is based on high-resolution HARPS-N at TNG and FEROS at ESO spectra and uniform techniques. Depending on stellar parameters and chemical elements, we used line equivalent widths or spectral synthesis methods. We derived kinematic properties taking advantage of Gaia data and for the first time in exoplanet host stars we estimated ages using elemental ratios as chemical clocks. Results. The effective temperature of our stars is ∼4400-6700 K, while the iron abundance [Fe/H] is within -0.3 and 0.4 dex. Lithium is present in seven stars. The [X/H] and [X/Fe] abundances versus [Fe/H] are consistent with the Galactic chemical evolution. The dependence of [X/Fe] with the condensation temperature is critically analyzed with respect to stellar and kinematic properties. All targets with measured C and O abundances show C/O < 0.8, compatible with Si present in rock-forming minerals. Mean C/O and [C/O] values are slightly lower than for the Sun. Most of targets show 1.0 < Mg/Si < 1.5, compatible with Mg distributed between olivine and pyroxene, and mean Mg/Si lower than for the Sun. HAT-P-26, the target hosting the lowest-mass planet, shows the highest Mg/Si ratio. From our chemodynamical analysis we find agreement between ages and position within the Galactic disk. Finally, we note a tendency for higher-density planets to be around metal-rich stars and hints of higher stellar abundances of some volatiles (e.g., O) for lower-mass planets. We cannot exclude that part of our results could be also related to the location of the stars within the Galactic disk. Conclusions. We try to trace the planetary migration scenario from the composition of the planets related to the chemical composition of the hosting stars. This kind of study will be useful for upcoming space mission data to get more insights into the formation-migration mechanisms
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The GAPS Programme at TNG: XXXV. Fundamental properties of transiting exoplanet host stars
Context. Exoplanetary properties strongly depend on stellar properties: to know the planet with accuracy and precision it is necessary to know the star as accurately and precisely as possible. Aims. Our immediate aim is to characterize in a homogeneous and accurate way a sample of 27 transiting planet-hosting stars observed within the Global Architecture of Planetary System program. For the wide visual binary XO-2, we considered both components (N: hosting a transiting planet; S: without a known transiting planet). Our final goal is to widely analyze the sample by deriving several stellar properties, abundances of many elements, kinematic parameters, and discuss them in the context of planetary formation. Methods. We determined the stellar parameters (effective temperature, surface gravity, rotational velocity) and abundances of 26 elements (Li, C, N, O, Na, Mg, Al, Si, S, Ca, Sc, Ti, V, Cr, Fe, Mn, Co, Ni, Cu, Zn, Y, Zr, Ba, La, Nd, Eu). Our study is based on high-resolution HARPS-N at TNG and FEROS at ESO spectra and uniform techniques. Depending on stellar parameters and chemical elements, we used line equivalent widths or spectral synthesis methods. We derived kinematic properties taking advantage of Gaia data and for the first time in exoplanet host stars we estimated ages using elemental ratios as chemical clocks. Results. The effective temperature of our stars is ∼4400-6700 K, while the iron abundance [Fe/H] is within -0.3 and 0.4 dex. Lithium is present in seven stars. The [X/H] and [X/Fe] abundances versus [Fe/H] are consistent with the Galactic chemical evolution. The dependence of [X/Fe] with the condensation temperature is critically analyzed with respect to stellar and kinematic properties. All targets with measured C and O abundances show C/O < 0.8, compatible with Si present in rock-forming minerals. Mean C/O and [C/O] values are slightly lower than for the Sun. Most of targets show 1.0 < Mg/Si < 1.5, compatible with Mg distributed between olivine and pyroxene, and mean Mg/Si lower than for the Sun. HAT-P-26, the target hosting the lowest-mass planet, shows the highest Mg/Si ratio. From our chemodynamical analysis we find agreement between ages and position within the Galactic disk. Finally, we note a tendency for higher-density planets to be around metal-rich stars and hints of higher stellar abundances of some volatiles (e.g., O) for lower-mass planets. We cannot exclude that part of our results could be also related to the location of the stars within the Galactic disk. Conclusions. We try to trace the planetary migration scenario from the composition of the planets related to the chemical composition of the hosting stars. This kind of study will be useful for upcoming space mission data to get more insights into the formation-migration mechanisms
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The GAPS Programme at TNG XXXVII. A precise density measurement of the young ultra-short period planet TOI-1807 b
Context. Great strides have been made in recent years in the understanding of the mechanisms involved in the formation and evolution of planetary systems. Despite this, many observational findings have not yet been corroborated by astrophysical explanations. A fine contribution to the study of planetary formation processes comes from the study of young, low-mass planets, with short orbital periods (.100 days). In the last three years, the NASA/TESS satellite has identified many planets of this kind and their characterization is clearly necessary in order to understand how they formed and evolved. Aims. Within the framework of the Global Architecture of Planetary System (GAPS) project, we performed a validation and characterization (radius and mass) of the ultra-short period planet TOI-1807 b, which orbits its young host star BD+39 2643 (∼300 Myr) in only 13 h. This is the youngest ultra-short period planet discovered so far. Methods. Thanks to a joint modeling of the stellar activity and planetary signals in the TESS light curve and in new HARPS-N radial-velocity measurements, combined with accurate estimation of stellar parameters, we validated the planetary nature of TOI-1807 b and measured its orbital and physical parameters. Results. By using astrometric, photometric, and spectroscopic observations, we found that BD+39 2643 is a young, active K dwarf star and a member of a 300 ± 80 Myr old moving group. Furthermore, it rotates in Prot = 8.8 ± 0.1 days. This star hosts an ultra-short period planet, exhibiting an orbital period of only Pb = 0.54937 ± 0.00001 days. Thanks to the exquisite photometric and spectroscopic series, along with the accurate information on its stellar activity, we measured both the radius and the mass of TOI-1807 b with high precision, obtaining RP,b = 1.37 ± 0.09 R⊕ and MP,b = 2.57 ± 0.50 M⊕. These planet parameters correspond to a rocky planet with an Earth-like density (ρb = 1.0 ± 0.3 ρ⊕) and no extended H/He envelope. From the analysis of the age-RP distribution for planets with well measured ages, we inferred that TOI-1807 b may have already lost a large part of its atmosphere over the course of its 300 Myr lifetime
The GAPS Programme with HARPS-N at TNG:. Atmospheric Rossiter-McLaughlin effect and improved parameters of KELT-9b
Neutral Iron Emission Lines from the Dayside of KELT-9b:The GAPS Program with HARPS-N at TNG XX
The GAPS programme at TNG XXXIX. Multiple molecular species in the atmosphere of the warm giant planet WASP-80 b unveiled at high resolution with GIANO-B
Interstellar matter and star formatio