Classification of consumer goods according to the generalized distance on six dimensions

社会学部設立十周年記念特

Classification of consumer goods according to the generalized distance on six psychologicaI dimensions

中井駿二教授古稀記念特

TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella

Cilia/flagella are assembled and maintained by the process of intraflagellar transport (IFT), a highly conserved mechanism involving more than 20 IFT proteins. However, the functions of individual IFT proteins are mostly unclear. To help address this issue, we focused on a putative IFT protein TTC26/DYF13. Using live imaging and biochemical approaches we show that TTC26/DYF13 is an IFT complex B protein in mammalian cells and Chlamydomonas reinhardtii. Knockdown of TTC26/DYF13 in zebrafish embryos or mutation of TTC26/DYF13 in C. reinhardtii, produced short cilia with abnormal motility. Surprisingly, IFT particle assembly and speed were normal in dyf13 mutant flagella, unlike in other IFT complex B mutants. Proteomic and biochemical analyses indicated a particular set of proteins involved in motility was specifically depleted in the dyf13 mutant. These results support the concept that different IFT proteins are responsible for different cargo subsets, providing a possible explanation for the complexity of the IFT machinery. DOI: http://dx.doi.org/10.7554/eLife.01566.00

Origin of activated combustion in steady-state premixed burner flame with superposition of dielectric barrier discharge

The objective of this work is to understand the mechanism of plasma-assisted combustion in a steady-state premixed burner flame. We examined the spatiotemporal variation of the density of atomic oxygen in a premixed burner flame with the superposition of dielectric barrier discharge (DBD). We also measured the spatiotemporal variations of the optical emission intensities of Ar and OH. The experimental results reveal that atomic oxygen produced in the preheating zone by electron impact plays a key role in the activation of combustion reactions. This understanding is consistent with that described in our previous paper indicating that the production of "cold OH(A(2) Sigma(+))" via CHO + O -> OH(A(2)Sigma(+)) + CO has the sensitive response to the pulsed current of DBD [K. Zaima and K. Sasaki, Jpn. J. Appl. Phys. 53, 110309 (2014)]

回腸新膀胱の2つのタイプの排尿

回腸新膀胱による禁制型尿路変向術を再発性表在性膀胱腫瘍8例に被膜下前立腺摘出下膀胱摘出後に施行し, 術後の排尿状態を検討した.患者は平均55.3歳, サントリニー静脈叢を結紮切除せず順行性に膀胱を切除後, 前立腺は膀胱頸部より2cm末梢側で切除し被膜下前立腺摘出した.1例で代用膀胱と尿道の間に3cmの腸管部分を残し, その蠕動運動のため排尿が著明に遷延し, 再手術を要した.他7名は脱管腔化した新膀胱を直接前立腺被膜に縫合し, 排尿は良好であった.内圧-尿流検査を7名に施行し, fast bladderとintermittent flowが見られ, 後者は排尿筋・括約筋協調不全様所見がみられたEight patients were evaluated clinically, radiologically, and urodynamically to determine the outcome of continent urinary diversion with ileal neobladder performed to treat the recurrent superficial bladder cancer after cystectomy with subcapsular prostatectomy. The mean age of the patients was 55.3 years. After descending dissection of the urinary bladder without ligation or dissection of Santorini's plexus, the prostate was cut to the bladder neck distally for 2 cm under the subcapular prostatectomy. One patient who had a short 3 cm intestinal segment between the pouch and the urethra, had severely prolonged micturition with peristalsis in this short segment, and required a re-operation. Micturition was good in the other seven patients, all with detubularized neobladder directly to the prostate capsule in anastomosis. Pressure flow studies performed on these seven patients revealed two types of micturition; "fast bladder" and "intermittent flow", the latter resembling detrusor sphincter dyssynergia

Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function

This is the peer reviewed version of the following article: Abe G.L., Sasaki J.I., Tsuboi R., et al. Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function. Journal of Biomedical Materials Research - Part B Applied Biomaterials 112, e35365 (2024), which has been published in final form at https://doi.org/10.1002/jbm.b.35365. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.Guided bone regeneration (GBR) is a treatment strategy used to recover bone volume. Barrier membranes are a key component of GBR protocols, and their properties can impact treatment outcomes. This study investigated the efficacy of an experimental, slow-degrading, bilayer barrier membrane for application in GBR using in vivo animal models. A synthetic copolymer of poly(lactic acid/caprolactone) (PLCL) was used to prepare a slow-degrading bilayer membrane. The biodegradability of PLCL was evaluated by subcutaneous implantation in a rat model. The barrier function of the PLCL membrane was investigated in a rat calvaria defect model and compared with commercially available membranes composed of type I collagen (Col) and poly(lactic-co-glycolic acid) (PLGA). An alveolar bone defect model in beagle dogs was used to simulate GBR protocols to evaluate the bone regeneration ability of the experimental PLCL membrane. The PLCL membrane showed slow biodegradation, resulting in an efficient and prolonged barrier function compared with commercial materials. In turn, this barrier function enabled the space-making ability of PLCL membrane and facilitated bone regeneration. In the alveolar bone defect model, significantly greater regeneration was achieved by treatment with PLCL membrane compared with Col and PLGA membranes. Additionally, a continuous alveolar ridge contour was observed in PLCL-treated bone defects. In conclusion, the PLCL bilayer membrane is a promising biomaterial for use in GBR given its slow degradation and prolonged barrier function

【ED診療の手順】 検査 特殊検査 ED専門医の行う検査

雑誌掲載

Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice

Recently it has been postulated that mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channels rather than sarcolemmal K(ATP) (sarcK(ATP)) channels are important as end effectors and/or triggers of ischemic preconditioning (IPC). To define the pathophysiological significance of sarcK(ATP) channels, we conducted functional experiments using Kir6.2-deficient (KO) mice. Metabolic inhibition with glucose-free, dinitrophenol-containing solution activated sarcK(ATP) current and shortened the action potential duration in ventricular cells isolated from wild-type (WT) but not KO mice. MitoK(ATP) channel function was preserved in KO ventricular cells. In anesthetized mice, IPC reduced the infarct size in WT but not KO mice. Following global ischemia/reperfusion, the increase of left ventricular end-diastolic pressure during ischemia was more marked, and the recovery of contractile function was worse, in KO hearts than in WT hearts. Treatment with HMR1098, a sarcK(ATP) channel blocker, but not 5-hydroxydecanoate, a mitoK(ATP) channel blocker, produced a deterioration of contractile function in WT hearts comparable to that of KO hearts. These findings suggest that sarcKATP channels figures prominently in modulating ischemia/reperfusion injury in the mouse. The rapid heart rate of the mouse (>600 beats per minute) may magnify the relative importance of sarcK(ATP) channels during ischemia, prompting caution in the extrapolation of the conclusions to larger mammals

Urethral hemangioma: How to investigate as a cause of hematuria after male sexual activities

Introduction Urethral hemangioma is an extremely rare occurrence and is not typically considered a common cause of hematuria. Since 2000, only 22 male cases have been reported. Case presentation A 45‐year‐old man presented with recurrent painless gross hematuria and the passage of blood clots after ejaculation. The patient underwent a transurethral resection of a 6‐mm hemangioma. This isolated sessile lesion was situated between the distal end of the verumontanum and the external sphincter, following an induced erection. The patient remained asymptomatic during the 1‐month follow‐up visit. Conclusion This study included the assessment of patient symptoms, diagnoses, and treatments and the literature review of 22 patients. We propose that relaxation of the external urethral sphincter muscle under general anesthesia and artificially inducing an erection can aid in the identification of urethral hemangiomas near the verumontanum during cystourethroscopy