766 research outputs found
Neutrinoless Double Beta Decay with SNO+
SNO+ will search for neutrinoless double beta decay by loading 780 tonnes of
linear alkylbenzene liquid scintillator with O(tonne) of neodymium. Using
natural Nd at 0.1% loading will provide 43.7 kg of 150Nd given its 5.6%
abundance and allow the experiment to reach a sensitivity to the effective
neutrino mass of 100-200 meV at 90% C.L in a 3 year run. The SNO+ detector has
ultra low backgrounds with 7000 tonnes of water shielding and self-shielding of
the scintillator. Distillation and several other purification techniques will
be used with the aim of achieving Borexino levels of backgrounds. The
experiment is fully funded and data taking with light-water will commence in
2012 with scintillator data following in 2013.Comment: 4 pages, 2 figures, prepared for TAUP 201
A preliminary review of the existing literature investigating ethnic and gender differences in early childhood development
There exist well documented inequalities in earnings by gender, race and ethnicity. Those disadvantaged groups are usually referred to together as minorities, where the majority is usually "White-male". Empirical research often attributes the lower earnings of minorities to their lower human capital endowments. One view is that minorities choose to invest less in human capital due to expected labour market discrimination. An alternative view is that lower human capital acquisition among the minorities could be determined by pre-labour market factors, such as their adverse socio-economic status. However, the age at which these ability gaps set in is not clear: one could argue that trajectory of these inequalities is established early on in childhood, and just gets accentuated by the adverse socio-economic status.
This paper reports on the findings of a preliminary review of the existing literature investigating ethnic and gender differences in early childhood development
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Adaptability of Closed-Loop during Labour, Delivery and Postpartum: A secondary analysis of data from two randomized crossover trials in type 1 diabetes pregnancy
Background: Tight glucose control during labour and delivery is recommended for pregnant women with type 1 diabetes. This can be challenging to achieve using the current treatment modalities. The automated nature of closed-loop and its ability to adapt to real-time glucose levels make it well suited for use during labour, delivery and the immediate postpartum period.
Methods: We report observational data of participants from two randomized crossover trials who chose to continue using closed-loop during labour, delivery and postpartum. Labour was defined as the 24 hours prior to delivery and postpartum as the 48 hours after delivery. The glucose target range during pregnancy was 3.5-7.8mmol/L (63-140mg/dL) and 3.9-10mmol/L (70-180mg/dL) after delivery.
Results: Twenty-seven (84.4%) of the potential 32 trial participants used closed-loop through labor, delivery, and postpartum. Use of closed-loop was associated with 82.0% (IQR 49.3,93.0) time-in-target range during labor and delivery and a mean glucose of 6.9±1.4mmol/L (124±25mg/dL). Closed-loop performed well throughout vaginal, elective and emergency caesarean section deliveries. Postpartum, women spent 83.3% (IQR 75.2,94.6) time-in-target range (3.9-10.0mmol/L [70-180mg/dL]), with a mean glucose of 7.2±1.4mmol/L (130±25mg/dL). There was no difference in maternal glucose concentration between mothers of infants with and without neonatal hypoglycemia (6.9±1.6 and 6.8±1.1 mmol/L [124±29 and 122±20mg/dL] respectively; p=0.84).
Conclusions: Automated closed-loop insulin delivery is feasible during hospital admissions for labour, delivery and postpartum. Larger scale studies are needed to evaluate its efficacyThe trials were funded by the National Institute for Health Research (HRM Career Development Fellowship, CDF-2013-06-035), Diabetes UK (BDA 07/0003551), Gates Cambridge Trust PhD fellowship (ZAS), Jean Hailes for Women’s Health (ZAS); Allen-Carey Scholarship in Women’s Health (JMY) and a grant from the NIHR Cambridge Biomedical Research Centre (RH). Abbott Diabetes Care supplied discounted CGM devices, sensors, and details of communication protocol to facilitate real-time connectivity. HRM conducts independent research supported by the National Institute for Health Research
The Firefighter Problem: A Structural Analysis
We consider the complexity of the firefighter problem where b>=1 firefighters
are available at each time step. This problem is proved NP-complete even on
trees of degree at most three and budget one (Finbow et al.,2007) and on trees
of bounded degree b+3 for any fixed budget b>=2 (Bazgan et al.,2012). In this
paper, we provide further insight into the complexity landscape of the problem
by showing that the pathwidth and the maximum degree of the input graph govern
its complexity. More precisely, we first prove that the problem is NP-complete
even on trees of pathwidth at most three for any fixed budget b>=1. We then
show that the problem turns out to be fixed parameter-tractable with respect to
the combined parameter "pathwidth" and "maximum degree" of the input graph
Human Vam6p promotes lysosome clustering and fusion in vivo
Regulated fusion of mammalian lysosomes is critical to their ability to acquire both internalized and biosynthetic materials. Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology to the Saccharomyces cerevisiae vacuolar protein sorting gene product Vam6p/Vps39p, the presence of a citron homology (CNH) domain at the NH2 terminus is unique to the human protein. Overexpression of hVam6p results in massive clustering and fusion of lysosomes and late endosomes into large (2–3 μm) juxtanuclear structures. This effect is reminiscent of that caused by expression of a constitutively activated Rab7. However, hVam6p exerts its effect even in the presence of a dominant-negative Rab7, suggesting that it functions either downstream of, or in parallel to, Rab7. Data from gradient fractionation, two-hybrid, and coimmunoprecipitation analyses suggest that hVam6p is a homooligomer, and that its self-assembly is mediated by a clathrin heavy chain repeat domain in the middle of the protein. Both the CNH and clathrin heavy chain repeat domains are required for induction of lysosome clustering and fusion. This study implicates hVam6p as a mammalian tethering/docking factor characterized with intrinsic ability to promote lysosome fusion in vivo
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor
The cation-independent mannose 6-phosphate receptor (CI-MPR) mediates sorting of lysosomal hydrolase precursors from the TGN to endosomes. After releasing the hydrolase precursors into the endosomal lumen, the unoccupied receptor returns to the TGN for further rounds of sorting. Here, we show that the mammalian retromer complex participates in this retrieval pathway. The hVps35 subunit of retromer interacts with the cytosolic domain of the CI-MPR. This interaction probably occurs in an endosomal compartment, where most of the retromer is localized. In particular, retromer is associated with tubular–vesicular profiles that emanate from early endosomes or from intermediates in the maturation from early to late endosomes. Depletion of retromer by RNA interference increases the lysosomal turnover of the CI-MPR, decreases cellular levels of lysosomal hydrolases, and causes swelling of lysosomes. These observations indicate that retromer prevents the delivery of the CI-MPR to lysosomes, probably by sequestration into endosome-derived tubules from where the receptor returns to the TGN
Search for the disappearance of muon antineutrinos in the NuMI neutrino beam
We report constraints on muon antineutrino oscillation parameters that were obtained by using the two MINOS detectors to measure the 7% antineutrino component of the NuMI neutrino beam. In the Far Detector, we select 130 events in the charged-current muon antineutrino sample, compared to a prediction of 136.4 +/- 11.7(stat) ^{+10.2}_{-8.9}(syst) events under the assumption |dm2bar|=2.32x10^-3 eV^2, snthetabar=1.0. A fit to the two-flavor oscillation approximation constrains |dm2bar|<3.37x10^-3 eV^2 at the 90% confidence level with snthetabar=1.0
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Short-term and long-term impact of continuous subcutaneous insulin infusion therapy on HbA1c changes in Type 1 diabetes
Short-term and long-term impact of continuous subcutaneous insulin infusion therapy on HbA1c changes in Type 1 diabetesGates Studentshi
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What factors are associated with success with insulin pumps?
What factors are associated with success with insulin pumps?Diabetes UK conference gran
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