31,619 research outputs found
Monopole clusters in Abelian projected gauge theories
We show that the monopole currents which one obtains in the maximally Abelian
gauge of SU(2) fall into two quite distinct classes (when the volume is large
enough). In each field configuration there is precisely one cluster that
permeates the whole lattice volume. It has a current density and a magnetic
screening mass that scale and it produces the whole of the string tension. The
remaining clusters have a number density that follows an approximate power law
proportional to the inverse cube of l where l is the length of the monopole
world line in lattice units. These clusters are localised in space-time with
radii which vary as the square root of l. In terms of the radius r these
`lumps' have a scale-invariant distribution proportional to (dr/r . 1/{r^4}).
Moreover they appear not to contribute at all to the string tension. The fact
that they are scale-invariant at small distances would seem to rule out an
instanton origin.Comment: LaTeX, 31 pages, 11 PostScript figures. Typo in Table 2 correcte
CRISPR/Cas9 gene editing therapies for cystic fibrosis
INTRODUCTION: Cystic fibrosis (CF) is a life-limiting genetic disorder affecting approximately 70,000 people worldwide. Current burden of treatment is high. While the latest pharmaceutical innovation has benefitted many, patients with certain genotypes remain excluded. Gene editing has the potential to correct the underlying cause of disease for all patients, representing a permanent cure. Areas covered: Various DNA editing-based strategies for treatment are currently being developed. Different strategies are called for based upon location of mutations (intronic vs. exonic), delivery mechanism of editing machinery, and cell type being targeted. Furthermore, the unique physiology of the CF lung presents a variety of barriers to delivery of CRISPR-Cas9 machinery. Expert opinion: The most significant obstacle to the use of CRISPR-Cas9 in vivo is the fact that the most clinically relevant and accessible CF tissue, the airway epithelium, is made up of non-dividing cells where precise editing via homology-directed repair (HDR) does not occur; rather, potentially deleterious imprecise editing via non-homologous end joining (NHEJ) dominates. Future research should focus on the development of either more precise NHEJ-based approaches, access to airway basal cells, editing approaches that do not involve introducing genomic double-strand breaks, and strategies with ex vivo edited cells
Query Complexity of Approximate Equilibria in Anonymous Games
We study the computation of equilibria of anonymous games, via algorithms
that may proceed via a sequence of adaptive queries to the game's payoff
function, assumed to be unknown initially. The general topic we consider is
\emph{query complexity}, that is, how many queries are necessary or sufficient
to compute an exact or approximate Nash equilibrium.
We show that exact equilibria cannot be found via query-efficient algorithms.
We also give an example of a 2-strategy, 3-player anonymous game that does not
have any exact Nash equilibrium in rational numbers. However, more positive
query-complexity bounds are attainable if either further symmetries of the
utility functions are assumed or we focus on approximate equilibria. We
investigate four sub-classes of anonymous games previously considered by
\cite{bfh09, dp14}.
Our main result is a new randomized query-efficient algorithm that finds a
-approximate Nash equilibrium querying
payoffs and runs in time . This improves on the running
time of pre-existing algorithms for approximate equilibria of anonymous games,
and is the first one to obtain an inverse polynomial approximation in
poly-time. We also show how this can be utilized as an efficient
polynomial-time approximation scheme (PTAS). Furthermore, we prove that
payoffs must be queried in order to find any
-well-supported Nash equilibrium, even by randomized algorithms
Impact of a theoretically based sex education programme (SHARE) delivered by teachers on NHS registered conceptions and terminations: final results of cluster randomised trial
<b>Objective</b>: To assess the impact of a theoretically based sex education programme (SHARE) delivered by teachers compared with conventional education in terms of conceptions and terminations registered by the NHS.
Design Follow-up of cluster randomised trial 4.5 years after intervention.
<b>Setting</b>: NHS records of women who had attended 25 secondary schools in east Scotland.
<b>Participants</b>: 4196 women (99.5% of those eligible).
<b>Intervention</b>: SHARE programme (intervention group) v existing sex education (control group).
<b>Main outcome measure</b>: NHS recorded conceptions and terminations for the achieved sample linked at age 20.
<b>Results</b>: In an "intention to treat" analysis there were no significant differences between the groups in registered conceptions per 1000 pupils (300 SHARE v 274 control; difference 26, 95% confidence interval –33 to 86) and terminations per 1000 pupils (127 v 112; difference 15, –13 to 42) between ages 16 and 20.
<b>Conclusions</b>: This specially designed sex education programme did not reduce conceptions or terminations by age 20 compared with conventional provision. The lack of effect was not due to quality of delivery. Enhancing teacher led school sex education beyond conventional provision in eastern Scotland is unlikely to reduce terminations in teenagers
Extent of regretted sexual intercourse among young teenagers in Scotland: a cross sectional survey
No abstract available
On the glueball spectrum in O(a)-improved lattice QCD
We calculate the light `glueball' mass spectrum in N_f=2 lattice QCD using a
fermion action that is non-perturbatively O(a) improved. We work at lattice
spacings a ~0.1 fm and with quark masses that range down to about half the
strange quark mass. We find the statistical errors to be moderate and under
control on relatively small ensembles. We compare our mass spectrum to that of
quenched QCD at the same value of a. Whilst the tensor mass is the same (within
errors), the scalar mass is significantly smaller in the dynamical lattice
theory, by a factor of ~(0.84 +/- 0.03). We discuss what the observed m_q
dependence of this suppression tells us about the dynamics of glueballs in QCD.
We also calculate the masses of flux tubes that wind around the spatial torus,
and extract the string tension from these. As we decrease the quark mass we see
a small but growing vacuum expectation value for the corresponding flux tube
operators. This provides clear evidence for `string breaking' and for the
(expected) breaking of the associated gauge centre symmetry by sea quarks.Comment: 33pp LaTeX. Version to appear in Phys. Rev.
The effects of stimulus modality and task integrality: Predicting dual-task performance and workload from single-task levels
The influence of stimulus modality and task difficulty on workload and performance was investigated. The goal was to quantify the cost (in terms of response time and experienced workload) incurred when essentially serial task components shared common elements (e.g., the response to one initiated the other) which could be accomplished in parallel. The experimental tasks were based on the Fittsberg paradigm; the solution to a SternBERG-type memory task determines which of two identical FITTS targets are acquired. Previous research suggested that such functionally integrated dual tasks are performed with substantially less workload and faster response times than would be predicted by suming single-task components when both are presented in the same stimulus modality (visual). The physical integration of task elements was varied (although their functional relationship remained the same) to determine whether dual-task facilitation would persist if task components were presented in different sensory modalities. Again, it was found that the cost of performing the two-stage task was considerably less than the sum of component single-task levels when both were presented visually. Less facilitation was found when task elements were presented in different sensory modalities. These results suggest the importance of distinguishing between concurrent tasks that complete for limited resources from those that beneficially share common resources when selecting the stimulus modalities for information displays
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Stand-replacing wildfires increase nitrification for decades in southwestern ponderosa pine forests.
Stand-replacing wildfires are a novel disturbance within ponderosa pine (Pinus ponderosa) forests of the southwestern United States, and they can convert forests to grasslands or shrublands for decades. While most research shows that soil inorganic N pools and fluxes return to pre-fire levels within a few years, we wondered if vegetation conversion (ponderosa pine to bunchgrass) following stand-replacing fires might be accompanied by a long-term shift in N cycling processes. Using a 34-year stand-replacing wildfire chronosequence with paired, adjacent unburned patches, we examined the long-term dynamics of net and gross nitrogen (N) transformations. We hypothesized that N availability in burned patches would become more similar to those in unburned patches over time after fire as these areas become re-vegetated. Burned patches had higher net and gross nitrification rates than unburned patches (P < 0.01 for both), and nitrification accounted for a greater proportion of N mineralization in burned patches for both net (P < 0.01) and gross (P < 0.04) N transformation measurements. However, trends with time-after-fire were not observed for any other variables. Our findings contrast with previous work, which suggested that high nitrification rates are a short-term response to disturbance. Furthermore, high nitrification rates at our site were not simply correlated with the presence of herbaceous vegetation. Instead, we suggest that stand-replacing wildfire triggers a shift in N cycling that is maintained for at least three decades by various factors, including a shift from a woody to an herbaceous ecosystem and the presence of fire-deposited charcoal
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