Farm Production Diversity and Household Dietary Diversity: Panel Data Evidence From Rural Households in Tanzania

Evidence on whether diversifying farm production leads to improved household dietary diversity and nutrition remains inconclusive. Existing studies analyzing the link between production diversity and dietary diversity are mainly based on cross-sectional methods, which could be biased by omitted confounding factors. Using two waves of a panel household survey of 900 rural households in Tanzania, this paper examines the link between production diversity and dietary diversity, while minimizing potential confounding effects. We estimate four regression models with two different production diversity measures and two panel estimation methods—fixed effect (FE) and random effect (RE). In three out of the four models, production diversity is significantly and positively associated with the dietary diversity measure of the food consumption score. The production diversity indicator is represented by the total crop and livestock species count, as well as by counting only crop species. The total crop and livestock species count shows a significant positive association with dietary diversity across estimation methods while the positive association with crop species count is not significant in the FE method. Our results suggest that the selection of appropriate production diversity indicators tailored to the specific circumstances of the local agricultural system is likely one key factor in identifying a robust relationship between production diversity and dietary diversity

Farm Production Diversity and Household Dietary Diversity: Panel Data Evidence From Rural Households in Tanzania

Evidence on whether diversifying farm production leads to improved household dietary diversity and nutrition remains inconclusive. Existing studies analyzing the link between production diversity and dietary diversity are mainly based on cross-sectional methods, which could be biased by omitted confounding factors. Using two waves of a panel household survey of 900 rural households in Tanzania, this paper examines the link between production diversity and dietary diversity, while minimizing potential confounding effects. We estimate four regression models with two different production diversity measures and two panel estimation methods—fixed effect (FE) and random effect (RE). In three out of the four models, production diversity is significantly and positively associated with the dietary diversity measure of the food consumption score. The production diversity indicator is represented by the total crop and livestock species count, as well as by counting only crop species. The total crop and livestock species count shows a significant positive association with dietary diversity across estimation methods while the positive association with crop species count is not significant in the FE method. Our results suggest that the selection of appropriate production diversity indicators tailored to the specific circumstances of the local agricultural system is likely one key factor in identifying a robust relationship between production diversity and dietary diversity.Peer Reviewe

Integrated food-based multi-actor approach to combat malnutrition

Despite initial progress, overall development toward zero hunger is not promising. Combating all forms of malnutrition is a complex challenge that requires complex answers from the local to global scales. To support a common understanding and to develop a joint approach that adequately addresses these challenges, an expert panel discussion was organized during the “Nutrition for Growth Summit Tokyo” on (7–8) December 2021 entitled “Multi-sectoral systems approach to holistically tackle malnutrition” upon which this article is based. We highpoint the requirement for actual access to ideas that move beyond the abstract and mostly figurative acknowledgment of the importance of bringing all actors together to combat malnutrition. Four entry points for a food-based multi-sectoral system approach to holistically tackle the burden of malnutrition were agreed upon. These entry points are not discrete, single entities but rather require integrated approaches. While we argue for an integrated approach building on all four interlinked components, it is important to note that the degree of each component's integration is context-dependent and that the examples presented as possible implementation strategies do not apply to all countries alike.Peer Reviewe

Psychophysiological effects of synchronous versus asynchronous music during cycling

"This is a non-final version of an article published in final form in (https://journals.lww.com/acsm-msse/pages/articleviewer.aspx?year=2014&issue=02000&article=00024&type=abstract )"Purpose: Synchronizing movement to a musical beat may reduce the metabolic cost of exercise, but findings to date have been equivocal. Our aim was to examine the degree to which the synchronous application of music moderates the metabolic demands of a cycle ergometer task. Methods: Twenty-three recreationally active men made two laboratory visits. During the first visit, participants completed a maximal incremental ramp test on a cycle ergometer. At the second visit, they completed four randomized 6-min cycling bouts at 90% of ventilatory threshold (control, metronome, synchronous music, and asynchronous music). Main outcome variables were oxygen uptake, HR, ratings of dyspnea and limb discomfort, affective valence, and arousal. Results: No significant differences were evident for oxygen uptake. HR was lower under the metronome condition (122 T 15 bpm) compared to asynchronous music (124 T 17 bpm) and control (125 T 16 bpm). Limb discomfort was lower while listening to the metronome (2.5 T 1.2) and synchronous music (2.3 T 1.1) compared to control (3.0 T 1.5). Both music conditions, synchronous (1.9 T 1.2) and asynchronous (2.1 T 1.3), elicited more positive affective valence compared to metronome (1.2 T 1.4) and control (1.2 T 1.2), while arousal was higher with synchronous music (3.4 T 0.9) compared to metronome (2.8 T 1.0) and control (2.8 T 0.9). Conclusions: Synchronizing movement to a rhythmic stimulus does not reduce metabolic cost but may lower limb discomfort. Moreover, synchronous music has a stronger effect on limb discomfort and arousal when compared to asynchronous music

Integrated food-based multi-actor approach to combat malnutrition

Despite initial progress, overall development toward zero hunger is not promising. Combating all forms of malnutrition is a complex challenge that requires complex answers from the local to global scales. To support a common understanding and to develop a joint approach that adequately addresses these challenges, an expert panel discussion was organized during the “Nutrition for Growth Summit Tokyo” on (7–8) December 2021 entitled “Multi-sectoral systems approach to holistically tackle malnutrition” upon which this article is based. We highpoint the requirement for actual access to ideas that move beyond the abstract and mostly figurative acknowledgment of the importance of bringing all actors together to combat malnutrition. Four entry points for a food-based multi-sectoral system approach to holistically tackle the burden of malnutrition were agreed upon. These entry points are not discrete, single entities but rather require integrated approaches. While we argue for an integrated approach building on all four interlinked components, it is important to note that the degree of each component's integration is context-dependent and that the examples presented as possible implementation strategies do not apply to all countries alike

The Lantern Vol. 30, No. 1, February 1963

• Mechanical Duplicity • The Practical Profits of Purism • \u27Tis Better • Misha • Manuel • An American Fairy Tale • The Christ of Christopher Street • Nocturne • Various Reflections • He Came and Gently Lifted Me • Poem, In a Minor Key • World Fell to Ruin • The Map • On Being Jilted • Manna • Traitor • The Leaves Cling • Oh Freedom! • The Insurance Man • Translation - The Vampire • Four Poems • Sanguis • Phoney is the Color of My Love\u27s Life • To a Barmaidhttps://digitalcommons.ursinus.edu/lantern/1083/thumbnail.jp

Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells

CD4-based decoy approaches against HIV-1 are attractive options for long-term viral control, but initial designs, including soluble CD4 (sCD4) and CD4-Ig, were ineffective. To evaluate a therapeutic that more accurately mimics HIV-1 target cells compared with monomeric sCD4 and dimeric CD4-Ig, we generated virus-like nanoparticles that present clusters of membrane-associated CD4 (CD4-VLPs) to permit high-avidity binding of trimeric HIV-1 envelope spikes. In neutralization assays, CD4-VLPs were >12,000-fold more potent than sCD4 and CD4-Ig and >100-fold more potent than the broadly neutralizing antibody (bNAb) 3BNC117, with >12,000-fold improvements against strains poorly neutralized by 3BNC117. CD4-VLPs also neutralized patient-derived viral isolates that were resistant to 3BNC117 and other bNAbs. Intraperitoneal injections of CD4-CCR5-VLP produced only subneutralizing plasma concentrations in HIV-1–infected humanized mice but elicited CD4-binding site mutations that reduced viral fitness. All mutant viruses showed reduced sensitivity to sCD4 and CD4-Ig but remained sensitive to neutralization by CD4-VLPs in vitro. In vitro evolution studies demonstrated that CD4-VLPs effectively controlled HIV-1 replication at neutralizing concentrations, and viral escape was not observed. Moreover, CD4-VLPs potently neutralized viral swarms that were completely resistant to CD4-Ig, suggesting that escape pathways that confer resistance against conventional CD4-based inhibitors are ineffective against CD4-VLPs. These findings suggest that therapeutics that mimic HIV-1 target cells could prevent viral escape by exposing a universal vulnerability of HIV-1: the requirement to bind CD4 on a target cell. We propose that therapeutic and delivery strategies that ensure durable bioavailability need to be developed to translate this concept into a clinically feasible functional cure therapy

Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells

CD4-based decoy approaches against HIV-1 are attractive options for long-term viral control, but initial designs, including soluble CD4 (sCD4) and CD4-Ig, were ineffective. To evaluate a therapeutic that more accurately mimics HIV-1 target cells compared with monomeric sCD4 and dimeric CD4-Ig, we generated virus-like nanoparticles that present clusters of membrane-associated CD4 (CD4-VLPs) to permit high-avidity binding of trimeric HIV-1 envelope spikes. In neutralization assays, CD4-VLPs were >12,000-fold more potent than sCD4 and CD4-Ig and >100-fold more potent than the broadly neutralizing antibody (bNAb) 3BNC117, with >12,000-fold improvements against strains poorly neutralized by 3BNC117. CD4-VLPs also neutralized patient-derived viral isolates that were resistant to 3BNC117 and other bNAbs. Intraperitoneal injections of CD4-CCR5-VLP produced only subneutralizing plasma concentrations in HIV-1–infected humanized mice but elicited CD4-binding site mutations that reduced viral fitness. All mutant viruses showed reduced sensitivity to sCD4 and CD4-Ig but remained sensitive to neutralization by CD4-VLPs in vitro. In vitro evolution studies demonstrated that CD4-VLPs effectively controlled HIV-1 replication at neutralizing concentrations, and viral escape was not observed. Moreover, CD4-VLPs potently neutralized viral swarms that were completely resistant to CD4-Ig, suggesting that escape pathways that confer resistance against conventional CD4-based inhibitors are ineffective against CD4-VLPs. These findings suggest that therapeutics that mimic HIV-1 target cells could prevent viral escape by exposing a universal vulnerability of HIV-1: the requirement to bind CD4 on a target cell. We propose that therapeutic and delivery strategies that ensure durable bioavailability need to be developed to translate this concept into a clinically feasible functional cure therapy