Book reviews

Teaching/Communication/Extension/Profession,

A Comparative Evaluation of Gait between Children with Autism and Typically Developing Matched Controls

Anecdotal reports suggest children with autism spectrum disorder (ASD) ambulate differently than peers with typical development (TD). Little empirical evidence supports these reports. Children with ASD exhibit delayed motor skills, and it is important to determine whether or not motor movement deficits exist during walking. The purpose of the study was to perform a comprehensive lower-extremity gait analysis between children (aged 5–12 years) with ASD and age- and gender-matched-samples with TD. Gait parameters were normalized to 101 data points and the gait cycle was divided into seven sub-phases. The Model Statistic procedure was used to test for statistical significance between matched-pairs throughout the entire gait cycle for each parameter. When collapsed across all participants, children with ASD exhibited large numbers of significant differences (p \u3c 0.05) throughout the gait cycle in hip, knee, and ankle joint positions as well as vertical and anterior/posterior ground reaction forces. Children with ASD exhibited unique differences throughout the gait cycle, which supports current literature on the heterogeneity of the disorder. The present work supports recent findings that motor movement differences may be a core symptom of ASD. Thus, individuals may benefit from therapeutic movement interventions that follow precision medicine guidelines by accounting for individual characteristics, given the unique movement differences observed

The Assignment of Errors in Appellate Briefs

Few subjects have troubled courts more and legal writers less than faulty assignments of error. Since the subject has received little attention outside the reports themselves, there has developed a mass of hitherto unassimilated case authority which, because of its size, is an obstacle rather than an aid to courts and attorneys. This article is the product of a survey of those cases. It will add little to the general store of information on the subject, but it is designed to do two things: (1) call the attention of the Bar to some of the clearer and better written discussions of the problem in the Washington cases, and (2) to segregate, throughout the footnotes, the particular decisions dealing with specific problems posed by the requirement that all briefs contain an assignment of the errors relied upon for reversal

High-Potential C112D/M121X (X = M, E, H, L) Pseudomonas aeruginosa Azurins

Site-directed mutagenesis of Pseudomonas aeruginosa azurin C112D at the M121 position has afforded a series of proteins with elevated Cu^(II/I) reduction potentials relative to the CuII aquo ion. The high potential and low axial hyperfine splitting (Cu^(II) electron paramagnetic resonance A|) of the C112D/M121L protein are remarkably similar to features normally associated with type 1 copper centers

Hinode EUV Imaging Spectrometer Observations of Solar Active Region Dynamics

The EUV Imaging Spectrometer (EIS) on the Hinode satellite is capable of measuring emission line center positions for Gaussian line profiles to a fraction of a spectral pixel, resulting in relative solar Doppler-shift measurements with an accuracy of less than a km/s for strong lines. We show an example of the application of that capability to an active region sit-and-stare observation in which the EIS slit is placed at one location on the Sun and many exposures are taken while the spacecraft tracking keeps the same solar location within the slit. For the active region examined (NOAA 10930), we find that significant intensity and Doppler-shift fluctuations as a function of time are present at a number of locations. These fluctuations appear to be similar to those observed in high-temperature emission lines with other space-borne spectroscopic instruments. With its increased sensitivity over earlier spectrometers and its ability to image many emission lines simultaneously, EIS should provide significant new constraints on Doppler-shift oscillations in the corona.Comment: 7 Pages, 7 figure

Phosphorus in Missouri soils (1993)

Revised October 1993

Observation and Modeling of Coronal "Moss" With the EUV Imaging Spectrometer on Hinode

Observations of transition region emission in solar active regions represent a powerful tool for determining the properties of hot coronal loops. In this Letter we present the analysis of new observations of active region moss taken with the Extreme Ultraviolet Imaging Spectrometer (EIS) on the \textit{Hinode} mission. We find that the intensities predicted by steady, uniformly heated loop models are too intense relative to the observations, consistent with previous work. To bring the model into agreement with the observations a filling factor of about 16% is required. Furthermore, our analysis indicates that the filling factor in the moss is nonuniform and varies inversely with the loop pressure

Synchronous vs Asynchronous Chain Motion in α-Synuclein Contact Dynamics

α-Synuclein (α-syn) is an intrinsically unstructured 140-residue neuronal protein of uncertain function that is implicated in the etiology of Parkinson’s disease. Tertiary contact formation rate constants in α-syn, determined from diffusion-limited electron-transfer kinetics measurements, are poorly approximated by simple random polymer theory. One source of the discrepancy between theory and experiment may be that interior-loop formation rates are not well approximated by end-to-end contact dynamics models. We have addressed this issue with Monte Carlo simulations to model asynchronous and synchronous motion of contacting sites in a random polymer. These simulations suggest that a dynamical drag effect may slow interior-loop formation rates by about a factor of 2 in comparison to end-to-end loops of comparable size. The additional deviations from random coil behavior in α-syn likely arise from clustering of hydrophobic residues in the disordered polypeptide

Planetary science

The following types of experiments for a proposed Space Station Microgravity Particle Research Facility are described: (1) low velocity collisions between fragile particles; (2) low velocity collisions of ice particles; (3) plasma-dust interaction; and (4) aggregation of finely-comminuted geological materials. The required capabilities and desired hardware for the facility are detailed