Book Reviews: Holdouts!; Downtown Retail Development Conditions for Success and Project Profiles

Book reviews of the following: HOLDOUTS!: In the heart of most American planners, there is a deep respect for the efforts of preservation activists. Planners are famous (and infamous) for their advocacy of "interesting" and "diverse" forms of urban development. Buildings of historic and/or architectural significance are guarded zealously. Functional, but perhaps unattractive, retail centers serving the commercial needs of low and moderate income residents often find protection in public planning. This alliance of planners and preservationists is poorly regarded by members of the development community, however. Developers challenge the "professional schizophrenia" of the planning profession; advocates of a "city beautiful" and a "diverse city" urban form effect contradictory planning decisions and confused planning policy. Holdouts!, by Andrew Alpern and Seymore Durst illustrates this policy contradiction in the context of New York City's redevelopment process. It is a graphic study of development compromises and real estate failure caused by the tenacious, stubborn and sometimes gallant preservation efforts of property owners and public planners. Holdouts! is a survey of over fifty-seven cases in New York City where "frightened holdouts", "greedy holdouts", "professional holdouts" and "foolish holdouts" frustrated the planning and development efforts of the city's largest real estate concerns. DOWNTOWN RETAIL DEVELOPMENT: CONDITIONS FOR SUCCESS AND PROJECT PROFILES: American planners would be poorer students and practitioners of real estate development without the efforts and publications of the Urban Land Institute. Among their most recent efforts is Downtown Retail Development; Conditions For Success and Project Profiles by J. Thomas Black, Libby Howland and Stuart Rogel. In this concise, yet comprehensive survey of retail development trends, strategies, and opportunties, the authors detail specific tools and policies available to public and private developers concerned with the revitalization of the nation's central business districts

Book Reviews: Revitalizing America's Cities; Environmental Regulation of Industrial Plant Siting; Getting to Yes

Book reviews of the following: REVITALIZING AMERICA'S CITIES: Revitalizing America's Cities, by Michael Schill and Richard Nathan, is a socioloqical study which attempts to identify and assess the measureable costs and benefits of urban neighborhood revitalization. The study provides an analysis of the reinvestment and redevelopment process within various neighborhoods of Boston, Cinncinnati, Denver, Richmond, and Seattle. Neighborhoods within these cities were selected on the basis of perceived changes in real estate sales, property values and demographic trends. The primary data for the analysis included census material, survey research findings and statements from local public officials. ENVIRONMENTAL REGULATION OF INDUSTRIAL PLANT SITING: In late 1969, Kelly Springfield Tire Company, a subsidiary of Goodyear, began searching for a site on which to build a new factory. The company chose Fayetteville, North Carolina, and thirteen months later produced its first tire. Just six years later, in 1975, Standard Oil of Ohio (SOHIO) announced plans to build a major crude oil terminal and pipeline at the port of Long Beach, California. Before the project could be started, it needed 60 environmental permits, and over three years later, SOHIO scrapped the terminal, citing environmental regulation as the problem. Clearly, the rules for siting industrial facilities had changed drastically by the mid-seventies, when serious environmental problems throughout the country caused all levels of government to enact many new environmental regulations. Corporate planners could no longer choose industrial sites by doing market analyses; they had to depend on qualifying for a series of environmental permits. Changing the rules of the industrial siting game has caused industry to claim that environmental regulations are blocking much needed economic growth. In Environmental Regulation of Industrial Plant Siting , Christopher J. Duerksen explains these concerns of industry by considering what he calls the myths of the impact of environmental regulation. GETTING TO YES: Getting to Yes by Fisher and Ury, is a practical guide to successful negotiation techniques and strategies. The book's concise and highly readable format have contributed to its best-seller status. The authors direct the Harvard Negotiation Project at Harvard University

Comparison of an enzyme-linked immunosorbent assay (ELISA) to gas chromatography (GC) - measurement of polychlorinated biphenyls (PCBs) in selected US fish extracts

The analysis of PCBs in fish tissues by immunoassay methods was evaluated using fish collected from a US monitoring program, the National Contaminant Biomonitoring Program of the US Department of Interior, Fish and Wildlife Service. Selected composite whole fish samples, which represented widely varying concentrations and sources of PCBs, were extracted and subjected to congener PCB analysis by gas chromatography (GC) and total PCB analysis using an ELISA (ePCBs) calibrated against technical Aroclor 1248. PCB congener patterns in these fishes were different from the patterns found in commercial Aroclors or their combinations as demonstrated by principal component analysis of normalized GC congener data. The sum of the PCB congeners measured by GC (total-PCBs) ranged from 37 to 4600 ng/g (wet weight). Concentrations of PCBs as determined by the ELISA method were positively correlated with total-PCBs and the ePCBs/total-PCBs ratios for individual samples ranged from 1 to 6. Ratios of ePCBs/total- PCBs for dilutions of Aroclors 1242, 1254, and 1260 and for matrix spikes range from 0.6 for 1242 to 2.5 for 1254 and 1260. These results suggest that higher chlorinated PCB congeners have higher anffinity for the anti-PCB antibodies. Partial least squares with latent variable analysis of GC and ELISA data of selected Aroclors and fish samples also support the conclusion that ELISA derived PCB concentrations are dependent on the degree of chlorination. © 1999 Elsevier Science Ltd. All rights reserved

Comparison of an enzyme-linked immunosorbent assay (ELISA) to gas chromatography (GC) - measurement of polychlorinated biphenyls (PCBs) in selected US fish extracts

The analysis of PCBs in fish tissues by immunoassay methods was evaluated using fish collected from a US monitoring program, the National Contaminant Biomonitoring Program of the US Department of Interior, Fish and Wildlife Service. Selected composite whole fish samples, which represented widely varying concentrations and sources of PCBs, were extracted and subjected to congener PCB analysis by gas chromatography (GC) and total PCB analysis using an ELISA (ePCBs) calibrated against technical Aroclor 1248. PCB congener patterns in these fishes were different from the patterns found in commercial Aroclors or their combinations as demonstrated by principal component analysis of normalized GC congener data. The sum of the PCB congeners measured by GC (total-PCBs) ranged from 37 to 4600 ng/g (wet weight). Concentrations of PCBs as determined by the ELISA method were positively correlated with total-PCBs and the ePCBs/total-PCBs ratios for individual samples ranged from 1 to 6. Ratios of ePCBs/total- PCBs for dilutions of Aroclors 1242, 1254, and 1260 and for matrix spikes range from 0.6 for 1242 to 2.5 for 1254 and 1260. These results suggest that higher chlorinated PCB congeners have higher anffinity for the anti-PCB antibodies. Partial least squares with latent variable analysis of GC and ELISA data of selected Aroclors and fish samples also support the conclusion that ELISA derived PCB concentrations are dependent on the degree of chlorination. © 1999 Elsevier Science Ltd. All rights reserved

Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders

Objective: Adenosine participates in maintaining the excitatory/inhibitory balance in neuronal circuits. Studies indicate that adenosine levels in the cortex and hippocampus increase and exert sleep pressure in sleep-deprived and control animals, whereas in epilepsy reduced adenosine tone promotes hyperexcitability. To date, the role of adenosine in pathological conditions that result in both seizures and sleep disorders is unknown. Here, we determined adenosine tone in sleep and seizure regulating brain regions of Kv1.1 knockout (KO) mice, a model of temporal epilepsy with comorbid sleep disorders. Methods: 1) Reverse phase-high performance liquid chromatography (RP-HPLC) was performed on brain tissue to determine levels of adenosine and adenine nucleotides. 2) Multi-electrode array extracellular electrophysiology was used to determine adenosine tone in the hippocampal CA1 region and the lateral hypothalamus (LH). Results: RP-HPLC indicated a non-significant decrease in adenosine (~50%, p = 0.23) in whole brain homogenates of KO mice. Regional examination of relative levels of adenine nucleotides indicated decreased ATP and increased AMP in the cortex and hippocampus and increased adenosine in cortical tissue. Using electrophysiological and pharmacological techniques, estimated adenosine levels were ~35% lower in the KO hippocampal CA1 region, and 1–2 fold higher in the KO LH. Moreover, the increased adenosine in KO LH contributed to lower spontaneous firing rates of putative wake-promoting orexin/hypocretin neurons. Interpretation: This is the first study to demonstrate a direct correlation of regionally distinct dichotomous adenosine levels in a single model with both epilepsy and comorbid sleep disorders. The weaker inhibitory tone in the dorsal hippocampus is consistent with lower seizure threshold, whereas increased adenosine in the LH is consistent with chronic partial sleep deprivation. This work furthers our understanding of how adenosine may contribute to pathological conditions that underlie sleep disorders within the epileptic brain

Software Citation Implementation Challenges

The main output of the FORCE11 Software Citation working group (https://www.force11.org/group/software-citation-working-group) was a paper on software citation principles (https://doi.org/10.7717/peerj-cs.86) published in September 2016. This paper laid out a set of six high-level principles for software citation (importance, credit and attribution, unique identification, persistence, accessibility, and specificity) and discussed how they could be used to implement software citation in the scholarly community. In a series of talks and other activities, we have promoted software citation using these increasingly accepted principles. At the time the initial paper was published, we also provided guidance and examples on how to make software citable, though we now realize there are unresolved problems with that guidance. The purpose of this document is to provide an explanation of current issues impacting scholarly attribution of research software, organize updated implementation guidance, and identify where best practices and solutions are still needed

The Grizzly, February 23, 1998

State Representative Speaks to the Ursinus Community • Bringing a Campus Together • Bass Voices His Views on Anti-Semitism • Opinion: Greeks Respond to Rudloff\u27s Article; Alumna Remembers Separate Dorms; A Faculty Member\u27s Concern on American Punishment; Interventionism as United States Policy? • The Grizzly Goes Online • French Exam No Problem for 5 UC Students • Mother Courage Takes the Stage • Specialty Housing News • Mike Green Speaks About A.A. • The Drawing Room Deceits • Basketball Updates • Water Polo, Anyone? • Asper, Johnson Provide Excitement at Regionals • Bears Travel to Hopkins for Playoffs • Men\u27s Hoops Win • Another Commendable Effort by Ursinus Gymnastshttps://digitalcommons.ursinus.edu/grizzlynews/1415/thumbnail.jp