Meeting the challenge of environmental data publication: an operational infrastructure and workflow for publishing data

Here we describe the defined workflow and its supporting infrastructure, which are used by the Natural Environment Research Council’s (NERC) Environmental Information Data Centre (EIDC) (http://​eidc.​ceh.​ac.​uk/​) to enable publication of environmental data in the fields of ecology and hydrology. The methods employed and issues discussed are also relevant to publication in other domains. By utilising a clearly defined workflow for data publication, we operate a fully auditable, quality controlled series of steps permitting publication of environmental data. The described methodology meets the needs of both data producers and data users, whose requirements are not always aligned. A stable, logically created infrastructure supporting data publication allows the process to occur in a well-managed and secure fashion, while remaining flexible enough to deal with a range of data types and user requirements. We discuss the primary issues arising from data publication, and describe how many of them have been resolved by the methods we have employed, with demonstrable results. In conclusion, we expand on future directions we wish to develop to aid data publication by both solving problems for data generators and improving the end-user experience

Implementation of a workflow for publishing citeable environmental data: successes, challenges and opportunities from a data centre perspective

In recent years, the development and implementation of a robust way to cite data have encouraged many previously sceptical environmental researchers to publish the data they create, thus ensuring that more data than ever are now open and available for re-use within and between research communities. Here, we describe a workflow for publishing citeable data in the context of the environmental sciences—an area spanning many domains and generating a vast array of heterogeneous data products. The processes and tools we have developed have enabled rapid publication of quality data products including datasets, models and model outputs which can be accessed, re-used and subsequently cited. However, there are still many challenges that need to be addressed before researchers in the environmental sciences fully accept the notion that datasets are valued outputs and time should be spent in properly describing, storing and citing them. Here, we identify current challenges such as citation of dynamic datasets and issues of recording and presenting citation metrics. In conclusion, whilst data centres may have the infrastructure, tools, resources and processes available to publish citeable datasets, further work is required before large-scale uptake of the services offered is achieved. We believe that once current challenges are met, data resources will be viewed similarly to journal publications as valued outputs in a researcher’s portfolio, and therefore both the quality and quantity of data published will increase

Journal publishing with Acrobat: the CAJUN project

The publication of material in electronic form should ideally preserve, in a unified document representation, all of the richness of the printed document while maintaining enough of its underlying structure to enable searching and other forms of semantic processing. Until recently it has been hard to find a document representation which combined these attributes and which also stood some chance of becoming a de facto multi-platform standard. This paper sets out experience gained within the Electronic Publishing Research Group at the University of Nottingham in using Adobe Acrobat software and its underlying PDF (Portable Document Format) notation. The CAJUN project1 (CD-ROM Acrobat Journals Using Networks) began in 1993 and has used Acrobat software to produce electronic versions of journal papers for network and CD-ROM dissemination. The paper describes the project's progress so far and also gives a brief assessment of PDF's suitability as a universal document interchange standard

Testing Lorentz invariance by use of vacuum and matter filled cavity resonators

We consider tests of Lorentz invariance for the photon and fermion sector that use vacuum and matter-filled cavities. Assumptions on the wave-function of the electrons in crystals are eliminated from the underlying theory and accurate sensitivity coefficients (including some exceptionally large ones) are calculated for various materials. We derive the Lorentz-violating shift in the index of refraction n, which leads to additional sensitivity for matter-filled cavities ; and to birefringence in initially isotropic media. Using published experimental data, we obtain improved bounds on Lorentz violation for photons and electrons at levels of 10^-15 and below. We discuss implications for future experiments and propose a new Michelson-Morley type experiment based on birefringence in matter.Comment: 15 pages, 8 table

Cobalt catalysts for the oxidation of diesel soot particulate

Ceria-supported materials prepared by three routes, coprecipitation from aqueous solution containing both Co2+ and Ce3+ ions, and impregnation of preformed ceria gel with either cobalt(II) nitrate or cobalt(II) acetate, have been investigated for catalytic activity towards oxidation of diesel soot. All three materials catalyze the conversion of diesel soot particulate to carbon dioxide under a flow of either 6 vol.% O2 or 0.5 vol.% NO + 6 vol.% O2 in helium in the temperature range 573?613 K. The temperature of maximum conversion rate shows a small dependence on the particular catalyst and the composition of the oxidant. Raman spectroscopy of the ceria-supported cobalt catalysts indicate that the cobalt is present as Co3O4, but its average particle size in Co/CeO2 impregnated with Co acetate is smaller than the other two Co/CeO2 preparations. Features in the temperature-programmed reduction (TPR) profiles in the range 500?600 K, coincident with the temperature of catalytic activity, appear to be associated with reduction of the cobalt, suggesting a redox-type mechanism assisted by oxygen spillover on the CeO2 support. In contrast, cobalt supported on alumina, silica, and tin(IV) oxide obtained by coprecipitation show much lower activity due to the presence of dispersed Co2+ ions in these materials although small amounts of Co3O4 may be present on alumina and tin(IV) oxide.Fil: Harrison, Philip G.. The University of Nottingham; Reino UnidoFil: Ball, Ian K.. The University of Nottingham; Reino Unido. University Of Nottingham; Reino UnidoFil: Daniell, Wayne. Ludwig Maximilians Universitat; AlemaniaFil: Lukinskas, Povilas. Ludwig Maximilians Universitat; AlemaniaFil: Céspedes, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica ; ArgentinaFil: Miro, Eduardo Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica ; ArgentinaFil: Ulla, Maria Alicia del H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica ; Argentin

Platelets: From Formation to Function

Platelets are small, anucleate cells that travel as resting discoid fragments in the circulation. Their average circulating life span is 8–9 days, and their formation is an elegant and finely orchestrated series of cellular processes known as megakaryocytopoiesis and thrombopoiesis. This involves the commitment of haematopoietic stem cells, proliferation, terminal differentiation of megakaryocytic progenitors and maturation of megakaryocytes to produce functional platelets. This complex process occurs in specialised endosteal and vascular niches in the bone marrow where megakaryocytes form proplatelet projections, releasing platelets into the circulation. Upon contact with an injured blood vessel, they prevent blood loss through processes of adhesion, activation and aggregation. Platelets play a central role in cardiovascular disease (CVD), both in the development of atherosclerosis and as the cellular mediator in the development of thrombosis. Platelets have diverse roles not limited to thrombosis/haemostasis, also being involved in many vascular inflammatory conditions. Depending on the physiological context, platelet functions may be protective or contribute to adverse thrombotic and inflammatory outcomes. In this chapter, we will discuss platelets in context of their formation and function. Because of their multifaceted role in maintaining physiological homeostasis, current and development of platelet function testing platforms will be discussed

Assessment of available evidence in the management of gallbladder and bile duct stones:a systematic review of international guidelines

BACKGROUND: Gallstone disease is a frequent disorder in the Western world with a prevalence of 10-20%. Recommendations for the assessment and management of gallstones vary internationally. The aim of this systematic review was to assess quality of guideline recommendations for treatment of gallstones. METHODS: PubMed, EMBASE and websites of relevant associations were systematically searched. Guidelines without a critical appraisal of literature were excluded. Quality of guidelines was determined using the AGREE II instrument. Recommendations without consensus or with low level of evidence were considered to define problem areas and clinical research gaps. RESULTS: Fourteen guidelines were included. Overall quality of guidelines was low, with a mean score of 57/100 (standard deviation 19). Five of 14 guidelines were considered suitable for use in clinical practice without modifications. Ten recommendations from all included guidelines were based on low level of evidence and subject to controversy. These included major topics, such as definition of symptomatic gallstones, indications for cholecystectomy and intraoperative cholangiography. CONCLUSION: Only five guidelines on gallstones are evidence-based and of a high quality, but even in these controversy exists on important topics. High quality evidence is needed in specific areas before an international guideline can be developed and endorsed worldwide