Identifying studies for systematic reviews - An example from medical imaging

Objectives: To determine if published figures on the proportion of articles included in systematic reviews and identified in electronic databases are applicable to an example from medical imaging. Methods: A systematic review was performed. Additionally, sensitivity and precision of a MEDLINE search were compared with values from three published searches, each customized for a specific field. Results: All articles included in the systematic review were in electronic databases. The MEDLINE search had low precision compared with searches in other fields. Conclusions: in a specific area of medical imaging, electronic databases, including MEDLINE, are reliable sources of articles

Like Parent, Like Child: Intergenerational Patterns of Cardiovascular Risk Factors at Midlife

Purpose: We aimed to assess the prevalence of four cardiovascular risk factors (obesity, diabetes, excessive alcohol intake, and cigarette smoking) for parents and their adult children at the same approximate midlife age. We also evaluated associations of parents' cardiovascular risk factors, childhood health exposures, and social contexts (i.e., family, school, and neighborhood) during adolescence with adult children's cardiovascular health at midlife. Methods: We used data from respondents at Wave V of the National Longitudinal Study of Adolescent to Adult Health who had corresponding parent (mostly mothers) data from Wave I. The final sample included 10,466 adult children with a mean age of 37.8 years. Descriptive statistics and logistic regression models were estimated, accounting for the National Longitudinal Study of Adolescent to Adult Health sampling design. Results: At similar ages (i.e., 35–45 years) to their parents, adult children had higher rates of excessive drinking and obesity than their parents, lower rates of diabetes, and similar rates of smoking. Adult children's health largely converged and correlated with their parents' health at similar ages. Cardiovascular risks for adult children were also significantly associated with their childhood health exposures and social contexts during adolescence. Some associations varied with respect to the health status of parents at Wave I. Conclusions: The cardiovascular risk of parents at midlife is strongly associated with the cardiovascular risk of their adult children at midlife. The status of parents' health during adolescence can also modify the significance and magnitude of associations between childhood health exposures or adolescent social contexts and adult children's cardiovascular risk factors

The Role of Family Health History in Predicting Midlife Chronic Disease Outcomes

Introduction: The generational relevance for determining disease risk for the leading causes of morbidity and mortality for U.S. adults is a source of debate. Methods: Data on 12,300 adults (Add Health Study Members) participating in Wave V (2016–2018) of the National Longitudinal Study of Adolescent to Adult Health (also known as Add Health) were merged with data from respondents’ parents (n=2,013) participating in the Add Health Parent Study (2015–2017). Analyses beginning in January 2020 examined the concordance in lifetime occurrence of chronic conditions across 4 generations, including cardiovascular disease, diabetes, hypertension, hyperlipidemia, obesity, cancer, and depression and examined the associations between individual disease history and ones’ family health history for the same condition. Results: Mean ages were 37.4 years for Add Health Study Members and 62.9 years for Add Health Parent Study mothers. The histories of mothers from the Add Health Parent Study on hyperlipidemia (AOR=1.61, 95% CI=1.04, 2.48), obesity (AOR=1.77, 95% CI=1.27, 2.48), and depression (AOR=1.87, 95% CI=1.19, 2.95) were significantly associated with increased odds of Add Health Study Member report of these conditions. Maternal great grandparent hyperlipidemia history was significantly associated with the Add Health Study Member hyperlipidemia (AOR=2.81, 95% CI=1.51, 5.21). Histories of diabetes in maternal grandfather (AOR=2.41, 95% CI=1.24, 4.69) and maternal great grandparent (AOR=3.05, 95% CI=1.45, 6.43) were significantly associated with Add Health Study Member diabetes. Each additional point in the Add Health Parent Study mothers’ cardiometabolic risk factor index was associated with an 11% increase (incidence rate ratio=1.11, 95% CI=1.04, 1.19) in the expected count of cardiometabolic risk conditions for the Add Health Study Members. Conclusions: Multigenerational health histories have value for quantifying the probability of diabetes, obesity, depression, and hyperlipidemia in early mid-adulthood. Family health history knowledge is relevant for health promotion and disease prevention strategies

Survival after postoperative morbidity: a longitudinal observational cohort study

Prolonged morbidity after surgery is associated with a risk of premature death for a longer duration than perhaps is commonly thought; however, this risk falls with time. We suggest that prolonged postoperative morbidity measured in this way may be a valid indicator of the quality of surgical healthcare. Our findings reinforce the importance of research and quality improvement initiatives aimed at reducing the duration and severity of postoperative complication

Can routine offering of influenza vaccination in office-based settings reduce racial and ethnic disparities in adult influenza vaccination?

BACKGROUND: Influenza vaccination remains below the federally targeted levels outlined in Healthy People 2020. Compared to non-Hispanic whites, racial and ethnic minorities are less likely to be vaccinated for influenza, despite being at increased risk for influenza-related complications and death. Also, vaccinated minorities are more likely to receive influenza vaccinations in office-based settings and less likely to use non-medical vaccination locations compared to non-Hispanic white vaccine users. OBJECTIVE: To assess the number of "missed opportunities" for influenza vaccination in office-based settings by race and ethnicity and the magnitude of potential vaccine uptake and reductions in racial and ethnic disparities in influenza vaccination if these "missed opportunities" were eliminated. DESIGN: National cross-sectional Internet survey administered between March 4 and March 14, 2010 in the United States. PARTICIPANTS: Non-Hispanic black, Hispanic and non-Hispanic white adults living in the United States (N = 3,418). MAIN MEASURES: We collected data on influenza vaccination, frequency and timing of healthcare visits, and self-reported compliance with a potential provider recommendation for vaccination during the 2009-2010 influenza season. "Missed opportunities" for seasonal influenza vaccination in office-based settings were defined as the number of unvaccinated respondents who reported at least one healthcare visit in the Fall and Winter of 2009-2010 and indicated their willingness to get vaccinated if a healthcare provider strongly recommended it. "Potential vaccine uptake" was defined as the sum of actual vaccine uptake and "missed opportunities." KEY RESULTS: The frequency of "missed opportunities" for influenza vaccination in office-based settings was significantly higher among racial and ethnic minorities than non-Hispanic whites. Eliminating these "missed opportunities" could have cut racial and ethnic disparities in influenza vaccination by roughly one half. CONCLUSIONS: Improved office-based practices regarding influenza vaccination could significantly impact Healthy People 2020 goals by increasing influenza vaccine uptake and reducing corresponding racial and ethnic disparities

Resolving the Outer Disks and Halos of Nearby Galaxies

In a hierarchical merging scenario, the outer parts of a galaxy are a fossil record of the galaxy's early history. Observations of the outer disks and halos of galaxies thus provide a tool to study individual galaxy histories and test formation theories. Locally, an impressive effort has been made to understand the halo of the Milky Way, Andromeda, and M33. However, due to the stochastic nature of halo formation, a better understanding of this process requires a large sample of galaxies with known halo properties. The GHOSTS project (PI: R. de Jong) aims to characterize the halos and outer portions of 14 nearby (D=4-14 Mpc) spiral galaxies using the Hubble Space Telescope. Detection of individual stars in the outer parts of these galaxies enables us to study both the morphological properties of the galaxies, and determine the stars' metallicity and age.Comment: Contributed talk; to appear in the proceedings of "Galaxies in the Local Volume" Sydney 8-13 July 200

The host range, annual cycle and parasitoids of the African rice gall midge Orseolia oryzivora (Diptera: Cecidomyiidae) in central and southeast Nigeria

Host range experiments and field sampling in Nigeria produced no evidence that African rice gall midge, Orseolia oryzivora Harris - Gagné, can develop on plants other than Oryza species. Sampling in three outbreak areas during 1994 showed that the insect's annual cycle varied according to the agroecological zone and rice cropping pattern. In the humid forest zone, Orseolia oryzivora persisted through the short dry season on ratoons of cultivated rice Oryza sativa at a rainfed site and on dry season rice crops at an irrigated one. In contrast, at rainfed sites in the moist savannah zone the pest survived the longer dry season on the perennial wild rice O. longistaminata, while ratoons and volunteers of O. sativa provided 'bridges' between the wild host and wet season rice crops. Early in the wet season at rainfed sites, galls of Orseolia oryzivora were not found at high density on wild rice, ratoons or volunteers. The heavy infestations which developed by October resulted primarily from rapid multiplication on rice crops themselves during the wet season. At all 13 sites sampled, the large majority of galls were found on fallow or cropped rice fields, rather than in ditches, bunds or uncultivated wetland, irrespective of the time of year or the hosts involved. From gall dissections, the parasitoids Aprostocetus procerae (Risbec) and Platygaster diplosisae Risbec caused over 30% mortality at some sites by October but generally increased too late to prevent crop damage. Implications of the results for the management of Orseolia oryzivora are discusse

Description of a new species of Orseolia (Diptera: Cecidomyiidae) from Paspalum in West Africa, with notes on its parasitoids, ecology and relevance to natural biological control of the African rice gall midge, O. oryzivora

Field sampling of grasses growing in and near rice fields at 12 sites in Nigeria during April/May 1994 recorded the presence of galls on Paspalum scrobiculatumat densities of up to 10.9 galls per m2. These galls were induced by Orseolia bonzii Harris, sp. n., which is described. This species is morphologically close to, but distinct from, the African rice gall midge, Orseolia oryzivora Harris & Gagné, with which it has been confused in earlier studies of that pest species. In host-transfer experiments O. bonzii did not transfer to rice, Oryza sativa. Six hymenopterous parasitoids were reared from galls of O. bonzii and the most abundant of these were Platygaster diplosisae Risbec, Aprostocetus nr. procerae (Risbec) and Neanastatusnr. cinctiventris Girault. Host-transfer experiments with the Platygasterand Aprostocetus species from O. bonzii on Paspalum indicated that the Platygaster may not transfer onto O. oryzivora on rice whereas the Aprostocetus does. The overlap between the parasitoid faunas of the two species of Orseolia is potentially useful as it may be possible to enhance the natural biological control of O. oryzivora by manipulating parasitoid populations on Paspalu

Neighborhood disadvantage across the transition from adolescence to adulthood and risk of metabolic syndrome

This study investigates the association between neighborhood disadvantage from adolescence to young adulthood and metabolic syndrome using a life course epidemiology framework. Data from the United States-based National Longitudinal Study of Adolescent to Adult Health (n = 9500)and a structural equation modeling approach were used to test neighborhood disadvantage across adolescence, emerging adulthood, and young adulthood in relation to metabolic syndrome. Adolescent neighborhood disadvantage was directly associated with metabolic syndrome in young adulthood. Evidence supporting an indirect association between adolescent neighborhood disadvantage and adult metabolic syndrome was not supported. Efforts to improve cardiometabolic health may benefit from strategies earlier in life