Hereditary Cancer Genetic Panel Testing: A Review of the Literature

Cancer genetic testing (CGT) is a powerful diagnostic test that improves cancer prevention and early detection among individuals at high genetic risk of cancer. Since the completion of the mapping of the Human Genome Project, CGT has become increasingly available in the clinical setting. However, as gene discovery and sequencing technology improve, the impact of these advancements on patients is less understood. The use of multigene cancer gene panel tests has become increasingly prevalent; as such, the likelihood of incidental or inconclusive findings has increased. The author conducted a literature review to outline the science on CGT methods, the psychosocial responses to testing among patients, and the unique role of nurses in this process. A significant gap in the literature exists regarding multigene cancer genetic panel tests and the associated experiences and decision-making processes among individuals who have had testing. Future research will specifically explore the experiences of young women with breast cancer who have undergone hereditary cancer risk assessment genetic panel testing that reveals incidental or inconclusive findings

Additional Ultracool White Dwarfs Found in the Sloan Digital Sky Survey

We identify seven new ultracool white dwarfs discovered in the Sloan Digital Sky Survey (SDSS). The SDSS photometry, spectra, and proper motions are presented, and additional BVRI data are given for these and other previously discovered ultracool white dwarfs. The observed colors span a remarkably wide range, qualitatively similar to colors predicted by models for very cool white dwarfs. One of the new stars (SDSS J1251+44) exhibits strong collision-induced absorption (CIA) in its spectra, while the spectra and colors of the other six are consistent with mild CIA. Another of the new discoveries (SDSS J2239+00A) is part of a binary system -- its companion is also a cool white dwarf, and other data indicate that the companion exhibits an infrared flux deficiency, making this the first binary system composed of two CIA white dwarfs. A third discovery (SDSS J0310-00) has weak Balmer emission lines. The proper motions of all seven stars are consistent with membership in the disk or thick disk.Comment: Accepted for Astrophysical Journal. 16 pages (includes 3 figures

SDSS Standard Star Catalog for Stripe 82: the Dawn of Industrial 1% Optical Photometry

We describe a standard star catalog constructed using multiple SDSS photometric observations (at least four per band, with a median of ten) in the $ugriz$ system. The catalog includes 1.01 million non-variable unresolved objects from the equatorial stripe 82 ($|\delta_{J2000}|<$ 1.266$^\circ$) in the RA range 20h 34m to 4h 00m, and with the corresponding $r$ band (approximately Johnson V band) magnitudes in the range 14--22. The distributions of measurements for individual sources demonstrate that the photometric pipeline correctly estimates random photometric errors, which are below 0.01 mag for stars brighter than (19.5, 20.5, 20.5, 20, 18.5) in $ugriz$, respectively (about twice as good as for individual SDSS runs). Several independent tests of the internal consistency suggest that the spatial variation of photometric zeropoints is not larger than $\sim$0.01 mag (rms). In addition to being the largest available dataset with optical photometry internally consistent at the $\sim$1% level, this catalog provides practical definition of the SDSS photometric system. Using this catalog, we show that photometric zeropoints for SDSS observing runs can be calibrated within nominal uncertainty of 2% even for data obtained through 1 mag thick clouds, and demonstrate the existence of He and H white dwarf sequences using photometric data alone. Based on the properties of this catalog, we conclude that upcoming large-scale optical surveys such as the Large Synoptic Survey Telescope will be capable of delivering robust 1% photometry for billions of sources.Comment: 63 pages, 24 figures, submitted to AJ, version with correct figures and catalog available from http://www.astro.washington.edu/ivezic/sdss/catalogs/stripe82.htm

Street-scale dispersion modelling framework of road-traffic derived air pollution in Hanoi, Vietnam

Traffic is an important source of air pollution in Vietnamese cities. The spatio-temporal variation of air pollution derived from traffic is poorly understood. Application of dispersion modelling can help but is hindered by the local scarcity of suitable input data. This study fills the data gap, by establishing a framework employing open-access global data to model emission from traffic activities in Hanoi. The outlined methodology explicitly defines road sources, calculates their emission, and employs background pollution profiles from Copernicus Atmospheric Monitoring Service (CAMS) to produce street-scale distribution maps for CO, PM10 and PM2.5. Pollution hotspots are found near major traffic flows with the highest hourly average CO, PM10 and PM2.5 concentrations at 1206, 87.5 and 61.5 μgm−3, respectively. The relationship between concentrations and properties of the road network is assessed. Motorcycles are the main emitters of the traffic sector. Emission from Heavy Good Vehicles dominate during the night, with contribution percentages increase as it gets further away from the city core. Modelled concentrations are underestimated mainly due to low vehicular emission factor. Adjusting emission factors according to vehicle quality in Vietnam greatly improves agreement. The presence of non-traffic emission sources contributes to the model underestimation. Results for comparisons of daily averaged PM values are broadly in agreement between models and observations; however, diurnal patters are skewed. This results partly from the uncertainties linked with background pollution levels from CAMS, and partly from non-traffic sources which are not accounted for here. Further work is needed to assess the use of CAMS's concentrations in Vietnam. Meteorological input contributes to the temporal disagreement between the model and observations. The impact is most noticeable with CO concentrations during morning traffic rush hours. This study recommends approaches to improve input for future model iterations and encourage applications of dispersion modelling studies in similar economic settings

Two More Candidate AM Canum Venaticorum (AM CVn) Binaries from the Sloan Digital Sky Survey

AM CVn systems are a select group of ultracompact binaries with the shortest orbital periods of any known binary subclass; mass-transfer is likely from a low-mass (partially-)degenerate secondary onto a white dwarf primary, driven by gravitational radiation. In the past few years, the Sloan Digital Sky Survey (SDSS) has provided five new AM CVns. Here we report on two further candidates selected from more recent SDSS data. SDSS J1208+3550 is similar to the earlier SDSS discoveries, recognized as an AM CVn via its distinctive spectrum which is dominated by helium emission. From the expanded SDSS Data Release 6 (DR6) spectroscopic area, we provide an updated surface density estimate for such AM CVns of order 10^{-3.1} to 10^{-2.5} per deg^2 for 15<g<20.5. In addition, we present another new candidate AM CVn, SDSS J2047+0008, that was discovered in the course of followup of SDSS-II supernova candidates. It shows nova-like outbursts in multi-epoch imaging data; in contrast to the other SDSS AM CVn discoveries, its (outburst) spectrum is dominated by helium absorption lines, reminiscent of KL Dra and 2003aw. The variability selection of SDSS J2047+0008 from the 300 deg^2 of SDSS Stripe 82 presages further AM CVn discoveries in future deep, multicolor, and time-domain surveys such as LSST. The new additions bring the total SDSS yield to seven AM CVns thus far, a substantial contribution to this rare subclass, versus the dozen previously known.Comment: 19 pages, 5 figures, 1 table; submitted to A

Two Rare Magnetic Cataclysmic Variables with Extreme Cyclotron Features Identified in the Sloan Digital Sky Survey

Two newly identified magnetic cataclysmic variables discovered in the Sloan Digital Sky Survey (SDSS), SDSSJ155331.12+551614.5 and SDSSJ132411.57+032050.5, have spectra showing highly prominent, narrow, strongly polarized cyclotron humps with amplitudes that vary on orbital periods of 4.39 and 2.6 hrs, respectively. In the former, the spacing of the humps indicates the 3rd and 4th harmonics in a magnetic field of ~60 MG. The narrowness of the cyclotron features and the lack of strong emission lines imply very low temperature plasmas and very low accretion rates, so that the accreting area is heated by particle collisions rather than accretion shocks. The detection of rare systems like these exemplifies the ability of the SDSS to find the lowest accretion rate close binaries.Comment: Accepted for publication in the Astrophysical Journal, vol. 583, February 1, 2003; slight revisions and additions in response to referee's comments; 17 pages, 6 figures, AASTeX v4.

An Initial Survey of White Dwarfs in the Sloan Digital Sky Survey

An initial assessment is made of white dwarf and hot subdwarf stars observed in the Sloan Digital Sky Survey. In a small area of sky (190 square degrees), observed much like the full survey will be, 269 white dwarfs and 56 hot subdwarfs are identified spectroscopically where only 44 white dwarfs and 5 hot subdwarfs were known previously. Most are ordinary DA (hydrogen atmosphere) and DB (helium) types. In addition, in the full survey to date, a number of WDs have been found with uncommon spectral types. Among these are blue DQ stars displaying lines of atomic carbon; red DQ stars showing molecular bands of C_2 with a wide variety of strengths; DZ stars where Ca and occasionally Mg, Na, and/or Fe lines are detected; and magnetic WDs with a wide range of magnetic field strengths in DA, DB, DQ, and (probably) DZ spectral types. Photometry alone allows identification of stars hotter than 12000 K, and the density of these stars for 15<g<20 is found to be ~2.2 deg^{-2} at Galactic latitudes 29-62 deg. Spectra are obtained for roughly half of these hot stars. The spectra show that, for 15<g<17, 40% of hot stars are WDs and the fraction of WDs rises to ~90% at g=20. The remainder are hot sdB and sdO stars.Comment: Accepted for AJ; 43 pages, including 12 figures and 5 table

The Milky Way Tomography With SDSS. III. Stellar Kinematics

We study Milky Way kinematics using a sample of 18.8 million main-sequence stars with r 20 degrees). We find that in the region defined by 1 kpc < Z < 5 kpc and 3 kpc < R < 13 kpc, the rotational velocity for disk stars smoothly decreases, and all three components of the velocity dispersion increase, with distance from the Galactic plane. In contrast, the velocity ellipsoid for halo stars is aligned with a spherical coordinate system and appears to be spatially invariant within the probed volume. The velocity distribution of nearby (Z < 1 kpc) K/M stars is complex, and cannot be described by a standard Schwarzschild ellipsoid. For stars in a distance-limited subsample of stars (< 100 pc), we detect a multi-modal velocity distribution consistent with that seen by HIPPARCOS. This strong non-Gaussianity significantly affects the measurements of the velocity-ellipsoid tilt and vertex deviation when using the Schwarzschild approximation. We develop and test a simple descriptive model for the overall kinematic behavior that captures these features over most of the probed volume, and can be used to search for substructure in kinematic and metallicity space. We use this model to predict further improvements in kinematic mapping of the Galaxy expected from Gaia and the Large Synoptic Survey Telescope.NSF AST-615991, AST-0707901, AST-0551161, AST-02-38683, AST-06-07634, AST-0807444, PHY05-51164NASA NAG5-13057, NAG5-13147, NNXO-8AH83GPhysics Frontier Center/Joint Institute for Nuclear Astrophysics (JINA) PHY 08-22648U.S. National Science FoundationMarie Curie Research Training Network ELSA (European Leadership in Space Astrometry) MRTN-CT-2006-033481Fermi Research Alliance, LLC, United States Department of Energy DE-AC02-07CH11359Alfred P. Sloan FoundationParticipating InstitutionsJapanese MonbukagakushoMax Planck SocietyHigher Education Funding Council for EnglandMcDonald Observator

The Milky Way Tomography with SDSS: III. Stellar Kinematics

We study Milky Way kinematics using a sample of 18.8 million main-sequence stars with r<20 and proper-motion measurements derived from SDSS and POSS astrometry, including ~170,000 stars with radial-velocity measurements from the SDSS spectroscopic survey. Distances to stars are determined using a photometric parallax relation, covering a distance range from ~100 pc to 10 kpc over a quarter of the sky at high Galactic latitudes (|b|>20 degrees). We find that in the region defined by 1 kpc <Z< 5 kpc and 3 kpc <R< 13 kpc, the rotational velocity for disk stars smoothly decreases, and all three components of the velocity dispersion increase, with distance from the Galactic plane. In contrast, the velocity ellipsoid for halo stars is aligned with a spherical coordinate system and appears to be spatially invariant within the probed volume. The velocity distribution of nearby ($Z<1$ kpc) K/M stars is complex, and cannot be described by a standard Schwarzschild ellipsoid. For stars in a distance-limited subsample of stars (<100 pc), we detect a multimodal velocity distribution consistent with that seen by HIPPARCOS. This strong non-Gaussianity significantly affects the measurements of the velocity ellipsoid tilt and vertex deviation when using the Schwarzschild approximation. We develop and test a simple descriptive model for the overall kinematic behavior that captures these features over most of the probed volume, and can be used to search for substructure in kinematic and metallicity space. We use this model to predict further improvements in kinematic mapping of the Galaxy expected from Gaia and LSST.Comment: 90 pages, 26 figures, submitted to Ap