WOMEN/FOSTER MOTHERS WHO FED THE HOLY PROPHET (P.B.U.H).

The Prophet of Islam, Hazrat Muhammad (PBUH) is the central personality of Islam. Each and every aspect of his life is of utmost importance to Muslims and thus is studied in detail by researchers and scholars of all times. The aspect of foster mothers of the Prophet PBUH is no different. The present article discusses in detail the names and person of those venerable women in history who got the honor of breastfeeding the Prophet PBUH. Special attention has been given to the research of Makhdoom Hashim Thathvi RA and his renowned book on this topic

Hemodynamic Comparison between modified saddle block and subarachnoid block for Transurethral Resection of Prostate

BACKGROUND:   Spinal anesthesia is often the mode of anesthesia in transurethral resection of prostate (TURP) albeit with risk of hypotension. However, hemodynamic derangement is often less pronounced in saddle block. This study was conducted to compare the mean fall in Mean arterial Pressure (MAP) and Heart rate (HR) between modified saddle block and subarachnoid block for TURP.  OBJECTIVE:   To compare the mean fall in MAP and HR between modified saddle block and subarachnoid block for TURP.  METHODS:   In this randomized controlled trial 120 patients undergoing elective TURP were included and divided into two groups. Group A Patients received subarachnoid block and Group B received modified saddle block. Baseline hemodynamics were recorded before and then at 5 minutes after anesthesia. All the collected data was entered into SPSS version 22 and analyzed. Quantitative data like age, BMI, ASA-PS score, duration of surgery and baseline hemodynamics were presented as means and standard deviations. The fall of mean arterial pressure (MAP) & heart rate (HR) were compared among groups by independent t test and P value < 0.05 was considered as statistically significant.   RESULTS:  Mean fall in MAP was 8.98±1.28 mmHg and 3.13±0.68 mmHg (p<0.001) in group A and B, respectively. Mean fall in HR was 7.17±0.98 and 2.78±0.59 (p<0.001) in group A and group B, respectively.  CONCLUSION:   Modified saddle block resulted in significantly decreased fall in MAP and HR as compared with subarachnoid block for TURP.  KEY WORDS:   Modified Saddle Block; Subarachnoid Block; Mean Arterial Pressure &nbsp

Prokinetic and laxative effects of the crude methanolic extract of Viola betonicifolia whole plant in rodents

Abstract Background: The present study was aimed to provide ethnopharmacological basis for the medicinal use of Viola betonicifolia whole plant in indigestion and constipation. Methods: Mice were used in in-vivo prokinetic and laxative studies while in-vitro experiments were conducted on isolated tissues of rabbit and guinea-pig gut preparations suspended in a tissue bath to measure isotonic contractions. Results: The crude methanolic extract of Viola betonicifolia (VBME) showed partially atropine-sensitive prokinetic (50 and 100 mg/kg) and laxative (30 and 100 mg/kg) activities in mice. When tested in isolated rabbit jejunum and guinea-pig ileum, VBME caused dose-dependent contractions at 0.01-0.3 mg/mL and 0.03-5 mg/mL, respectively. The spasmogenic effect was partially sensitive to atropine, while the presence of pyrilamine, SB203186 or hexamethonium had no effect in both gut preparations. VBME partially inhibited acetylcholinesterase enzyme (19%) in the in-vitro assay. The spasmodic effect of VBME was more efficacious in guinea-pig ileum than rabbit jejunum preparation. The phytochemical analysis of the crude methanolic extract for total alkaloids and saponins revealed that the VBME is a rich source of alkaloids and saponins. Conclusions: This study showed the prokinetic and laxative effects of Viola betonicifolia in mice, partially mediated through cholinergic action. The in-vitro spasmodic effect of the plant extract was also partially sensitive to atropine indicating more than one mechanisms in the gut stimulant effect. This study provides a rationale for the medicinal use of Viola betonicifolia in indigestion and constipation

Effects of IV Magnesium Sulphate on Hemodynamic Response To Pneumoperitoneum In Laparoscopic Cholecyctectomy; A Randomized Control Trial

Objective: To determine the effect of IV Magnesium sulphate (MgSO4) in attenuating the hemodynamic effects of pneumoperitoneum. Methodology: Our single blind randomized control trial (based on computer generated randomize allocation) was carried out at Holy Family Hospital and included 60 patients, not allergic to MgSO4 and belonging to the American Society of Anesthesiology (class 1 and 2. Patients were divided into two groups with Intervention group (M group) receiving 30 mg/kg of MgSO4 and the control group (C group) receiving a placebo. Hemodynamic parameters were then measured at different points of time during surgery. Data was collected and analyzed by using statistical package for the social sciences (SPSS) version 25.0. Results: Out of 60 patients selected 86.7% were females while 13.3% were males. Mean age was 35.78(SD=8.26). As compared to group, patients belonging to group had significantly lower heart rate, systolic and diastolic blood pressure at 15 minutes, after release of pneumoperitoneum and at extubation with p values less than 0.05. Conclusion: Our study concludes that 30 mg/kg of MgSO4 given as a bolus just before creation of pneumoperitoneum protect against its possible adverse hemodynamic effects

Assessment of apparent diffusion coefficient values as predictor of aggressiveness in peripheral zone prostate cancer: comparison with Gleason score

Purpose. To determine association between apparent diffusion coefficient value on diffusion-weighted imaging and Gleason score in patients with prostate cancer. Methods. This retrospective case series was conducted at Radiology Department of Aga Khan University between June 2009 and June 2011. 28 patients with biopsy-proven prostate cancer were included who underwent ultrasound guided sextant prostate biopsy and MRI. MRI images were analyzed on diagnostic console and regions of interest were drawn. Data were entered and analyzed on SPSS 20.0. ADC values were compared with Gleason score using one-way ANOVA test. Results. In 28 patients, 168 quadrants were biopsied and 106 quadrants were positive for malignancy. 89 lesions with proven malignancy showed diffusion restriction. The mean ADC value for disease with a Gleason score of 6 was 935mm(2)/s (SD = 248.4mm(2)/s); Gleason score of 7 was 837mm(2)/s (SD = 208.5mm(2)/s); Gleason score of 8 was 614mm(2)/s (SD = 108mm(2)/s); and Gleason score of 9 was 571mm(2)/s (SD = 82mm(2)/s). Inverse relationship was observed between Gleason score and mean ADC values. Conclusion. DWI and specifically quantitative ADC values may help differentiate between low-risk (Gleason score, 6), intermediate-risk (Gleason score, 7), and high-risk (Gleason score 8 and 9) prostate cancers, indirectly determining the aggressiveness of the disease

DESIGN, DEVELOPMENT AND PERFORMANCE OF OPTIMUM WATER SOFTENER

Water is an important factor of life for all living organisms and it is now deteriorated very rapidly due to industrial effluents, municipal and agriculture waste leaching down the groundwater. The percolation of water through the deposits of limestone and chalk which are largely made up of calcium and magnesium carbonates increases the mineral contents. So, the presence of high mineral contents creates water hardness. Water hardness is mainly occurring by the existence of calcium and magnesium, their high concentration in water makes water hard which cause several hazardous impacts on human life. Therefore, certain concentration standard limits have been fixed by different organizations. According to WHO 500 mg/l is allowable limit for water hardness. So regular use of high concentration of Calcium and magnesium ions above standard limits is causing real problems for human beings and environment. In daily routine life different harmful incidence occurs due to hard water. To overcome this problem water softening is a technique that serves the removal of cations which are most likely the hardness factors are calcium and magnesium. Water softening is the most useful technique to remove hardness. Therefore, a water softener is developed for domestic purpose. As the development of an optimum water softener was very essential for domestic use. The water softener can have performed efficiently with a hardness range of 1000-1200 mg/l and TDS may be up to 1500mg/l. The water softener plant is also cost efficient that have almost one-time production cost and very low maintenance and running cost. After the manufacturing of water softening plant hardness, pH, DO, TDS and EC is calculated to check its efficiency. The hardness, TDS and conductivity reduces after passing the sample water through the sample, DO was increased to little extent and pH was remained in a specific rang

Quality of Hypospadias Surgery in a High Volume Hospital: Review of Short to Medium-Term Outcomes after Snodgrass Hypospadias Repair

OBJECTIVES The study aimed to review short-term and medium-term outcomes of Snodgrass repair from one-year to two-year follow-up. METHODOLOGY It’s a retrospective review of 114 patients (secondary data) with distal penile hypospadias without curvature who underwent Snodgrass repair performed by a single surgeon in the department of Urology, Lady Reading Hospital Peshawar from March 2021 to March 2022. Hypospadias objective score Evaluation (HOSE) was used for functional and cosmetic outcomes. RESULTSThe mean age at the time of presentation for surgery was 3 years. The mean documented follow-up was 13 months (2-23 months). 51% (58) of patients presented with coronal hypospadias, followed by sub-coronal, distal and glanular hypospadias. Overall complication rate was 10%. Three patients developed a total breakdown of their wounds that needed further staged procedures. Meatal stenosis was noted in three patients requiring meatal dilatation, and another two came back with non-obliterative strictures. One had gentle dilatation, and the other underwent an optical urethrotomy. The rest of the four patients developed urethrocutanoeus fistulae (UCF), ultimately getting repaired 6 months postoperatively. Good cosmetic and functional results were achieved in 93% of cases (HOSE score of 14 or above). CONCLUSION This study shows that Snodgrass repair is the best option for mainly correcting distal penile and midshaft hypospadias and has an acceptably low complication rate with better short to medium-term outcomes

Food Dehydration Recent Advances and Approaches

Dehydration of organic material is undoubtedly a controlled attempt to conserve or construct a novel construct that will satisfy functional devotions. Food dehydration is reviewed in light of the latest progress in food materials research. Understanding the mechanics behind the drying process is crucial in food and agricultural product dehydration. Among the most crucial steps in preserving food is dehydration. Food drying innovations include photovoltaic, thermal imaging, microwave-assisted, and comparable hybrid technologies. According to a recent study, unique food dehydration technologies might increase drying efficiency by decreasing energy usage while improving product quality. Unique drying methods reduce food component degradation and create novel items for customers. Each method’s use of specific foods will be reviewed in this chapter