Проектирование бизнес-модели спортивного квест-рума «SportQuest»

Цель данной выпускной квалификационной работы – разработка бизнес-модели стартап-проекта по реализации спортивно-развлекательных квестов для населения города Томска. Задачи, которые поставлены для достижения цели: – Проанализировать рынок квест-румов и отдельно спортивных квест-румов в мире, России и городе Томске; – Охарактеризовать бизнес-идею спортивного квест-рума и каждый из видов квеста в стартап-проекте – Построить бизнес-модель стартап-проекта и произвести расчёт показателей эффективности реализации проекта и определить его перспективность в реализации. Объект исследования – спортивный квест-рум в городе Томске. Предмет исследования – бизнес-модель спортивного квест-рума.The purpose of this final qualification work is to develop a business model for a startup project to implement sports and entertainment quests for the population of the city of Tomsk. Tasks that are set to achieve the goal: - Analyze the market of quest rooms and sports quest rooms separately in the world, Russia and the city of Tomsk; - Describe the business idea of the sports quest room and each of the types of quests in the startup project -Build a business model of the startup project and calculate the performance indicators of the project and determine its prospects for implementation. The object of the study is a sports quest room in the city of Tomsk. The subject of the research is the business model of a sports quest room

Feasibility of Prehospital Teleconsultation in Acute Stroke – A Pilot Study in Clinical Routine

BACKGROUND: Inter-hospital teleconsultation improves stroke care. To transfer this concept into the emergency medical service (EMS), the feasibility and effects of prehospital teleconsultation were investigated. METHODOLOGY/PRINCIPAL FINDINGS: Teleconsultation enabling audio communication, real-time video streaming, vital data and still picture transmission was conducted between an ambulance and a teleconsultation center. Pre-notification of the hospital was carried out with a 14-item stroke history checklist via e-mail-to-fax. Beside technical assessments possible influences on prehospital and initial in-hospital time intervals, prehospital diagnostic accuracy and the transfer of stroke specific data were investigated by comparing telemedically assisted prehospital care (telemedicine group) with local regular EMS care (control group). All prehospital stroke patients over a 5-month period were included during weekdays (7.30 a.m.-4.00 p.m.). In 3 of 18 missions partial dropouts of the system occurred; neurological co-evaluation via video transmission was conducted in 12 cases. The stroke checklist was transmitted in 14 cases (78%). Telemedicine group (n = 18) vs. control group (n = 47): Prehospital time intervals were comparable, but in both groups the door to brain imaging times were longer than recommended (median 59.5 vs. 57.5 min, p = 0.6447). The prehospital stroke diagnosis was confirmed in 61% vs. 67%, p = 0.8451. Medians of 14 (IQR 9) vs. 5 (IQR 2) stroke specific items were transferred in written form to the in-hospital setting, p<0.0001. In 3 of 10 vs. 5 of 27 patients with cerebral ischemia thrombolytics were administered, p = 0.655. CONCLUSIONS: Teleconsultation was feasible but technical performance and reliability have to be improved. The approach led to better stroke specific information; however, a superiority over regular EMS care was not found and in-hospital time intervals were unacceptably long in both groups. The feasibility of prehospital tele-stroke consultation has future potential to improve emergency care especially when no highly trained personnel are on-scene. TRIAL REGISTRATION: International Standard Randomised Controlled Trial Number Register (ISRCTN) ISRCTN83270177

Independent induction of two blue light-dependent monovalent anion transport systems in the plasma membrane of Monoraphidium braunii

In the plasma membrane of the green alga Monoraphidium braunii there are at least two monovalent anion transport systems. One of them is specific for bicarbonate. This transport system is activated by blue light and its induction is triggered by a decrease in the external CO2 concentration. The second transport system is responsible for nitrate uptake at least. This transport system is also activated by blue light and its induction occurs when there is no ammonium in the external medium. Both transport systems are synthesized independently. Hence, when M. braunii cells grow with nitrate as the only nitrogen source under high CO2, they have a nitrate transport system but lack a bicarbonate transporter. Conversely, cells grown with ammonium under low CO2, have a bicarbonate transport system but lack a nitrate transporter. Both transport systems are induced in cells irradiated with white light in the absence of a carbon source, suggesting that there may be precursors in the plasma membrane that only need the synthesis and assembly of some component(s) to become fully active. The induction of nitrate and nitrite reductases, however, only takes place when a carbon source is supplied to the cells.Peer reviewe