The Grizzly, February 13, 1987

Greek Life Grits Teeth at State\u27s Hazing Law • Free Roses for Lorelei • Letter: Fellow Student Reports on Chang • News Notes: R.A. Selection Underway; St. Andrew\u27s Scholarship; National Women in Sports Day • Bears Bump LaSalle and Haverford, Racich Wins 100th • Udovich\u27s Career High Leaves Bears to 74-69 Win • Mer Men\u27s Streak Ends vs. Loyola • Gymnastics Takes Fourth Win • Track Men Break Records • Swimmin Women on Warpathhttps://digitalcommons.ursinus.edu/grizzlynews/1181/thumbnail.jp

The Grizzly, November 14, 1986

Alumnae Jean Garton Returns to Present Controversial Abortion Lecture • Fall Board Meeting Convenes With Retirement Plan and $1000 Tuition Increase • Women Finish 2nd in MAC Cross-Country • Letters: Still the Same After All These Years; Butting; Self-Discipline • Floodgates Should Fly Open for Greaseband Experiment • Renowned Organist to Give Concert • ProTheatre Stages Three More Gems • Profile: Annette Lucas • Red & Gold Days Reflect Well on Ursinus Life • Men\u27s Cross-Country Runs Through Muddy Course to Place 4th in MAC\u27s • Breathing Life Into a Long Sleeping Lady Hoop Program • Brown Hangs Head Now, But Young Passing Attack Sparkles • Dickinson Drowns Ursinus Swimmers in Opener • Dean, AD Discuss Drugs • New Coach Key to Gymnastics\u27 Perfect 10 • Women\u27s Studieshttps://digitalcommons.ursinus.edu/grizzlynews/1175/thumbnail.jp

The Grizzly, February 27, 1987

Depts., Dean, Court New Faculty Free Agent Team • No Busts, But Bummer Booze Bar Dims Lorelei • Grizzly Poll Points Couple to Final Home • Letters: Impossible Crossings?; Adoption Instead of Abortion; Plea for Soviet Jewry • Ecoliers de Francais: Fly to France Pour Parler • Treasuring Modern Art Takes Time ... And Protest • Men\u27s B-Ball Sponsors Art Auction • Fencing Alive at Ursinus • Bears, 20-3, Looking for Fourth or Better at MAC • Swimmers to Celebrate Wins With Skins • Women Runners Capture MAC Title • Men\u27s Track Runs Third at MAC\u27s • Swimmin\u27 Women Go to MAC\u27s • Notes: Meistersingers\u27 50th Tour; Chambliss Family Lecture; Upcoming Forum Scheduled • Bear Dave Durst Dominates Entering MAC Tourney • Migliore Caps Nine-Letter Career with Athlete of the Week Honors • Two U.C. Gymnasts Go to Nat\u27ls • Robert Cray Band\u27s Strong Persuader Receives a B plushttps://digitalcommons.ursinus.edu/grizzlynews/1183/thumbnail.jp

The Grizzly, February 5, 1988

Cavorting Cop Caught • Lewis Disclaims Labels at Forum • Rock\u27N America • Patterns Campaign Nears Completion • Hockey Held as Hokey • Contra-versial Censorship Irks Student • History Department Interviews a New Way • Concert Features Christian Music • Summer Study in France a Fun-do • Notes: R.A. Rap Session Announced; Presidency Probers Convene; ALF Re-runs Rewarding; Child Safety Course Offered • Men\u27s Hoopsters Suffer Temporary Setback • Track Team Making Great Strides • Record Books Rewritten • U.C. Matters: Wrestling Tough and Confident • Men \u27Mers Holding Their Ownhttps://digitalcommons.ursinus.edu/grizzlynews/1203/thumbnail.jp

The Grizzly, December 15, 1986

Letters: Appeal for Artists; Use Common Sense in Regard to Smoke Alarms; Abortion Issue Spawns Another Challenge • Weeding Out the Weak at Musser • After a Prosperous Decade as President, Richter Reflects on his Life at Ursinus • Wrestling Wraps Up Winter With Albright White-Washing • Swimmin\u27 Women get a Trimmin\u27 • Varsity Hoopsters Even Season • All-American Avenue: Football\u27s Odgers; Field Hockey\u27s Johnson; Volleyball\u27s Kraszewski • Gymnastics Team Scores High in Season Opener • Letters: Court Conditions Cause Day\u27s Resignation; Coaching Cited as B-ball\u27s Achilles Heel • Students Able to Create Their Own Courses by Way of College Scholars Program • Going From Bare Douglas Fir to Santa\u27s Showplace • Tumarkin Gives Personal View of his Aggressive Couple • Ursinus\u27 Oldest Symbol • Kutztown Edges Lady-Bears • Weisel Given Peace Prize for Reminding World of the Nazi Horrors • David Marx Tells of Life Under Apartheid • Cub & Key / Sororities\u27 Phonathons • Promoting International Education at Ursinushttps://digitalcommons.ursinus.edu/grizzlynews/1178/thumbnail.jp

The Grizzly, January 30, 1987

U.C. Master Plan Features Art, Roads, Humanities Building • Aggressive Couple Sparks Conflicts and Challenges • Art Critic to Explain Sculpture • Letter: Abortion Issue\u27s Indefinite Life • Editorial: Silent Scream Meets U.C. Yawn • News Notes: Effectiveness Training Course Offered; Stress Management Workshops; Who\u27s Who at Ursinus?; Voice Workshop Offered; Enhance Self Presentation; Grammar and Writing Course • Jones Recalls Fetterolf of Yesteryear • Racich has Bears Rolling Toward MAC Riches • Bear Hoopsters Fall From First • Men Mers Rip Scranton in First Historical Meeting • Men\u27s Track Banking on Distance and Field • Gymnasts Open Semester With Split • Soccer\u27s Quinn a Standout • Swimmin\u27 Women Use Off-Season Workouts to Advantage at 3-3 • Odgers Makes Grade on and off Field • Davidson Assumes Presidency of PSAHPERD • Arthur Vining Davis Foundation Offers $60,000 to Support Residential Village • Development\u27s Randolph Introduces STAR Committee • Alderfer Takes Championship, Badminton Opens • Gall Finds the Way it is Fresh and New • Lionarons Leads Lecture • 1987 Class Chairmen Sought by Applicationhttps://digitalcommons.ursinus.edu/grizzlynews/1179/thumbnail.jp

The Grizzly, January 29, 1988

Social Changes at Ursinus Become Evident • New Student Center Instituted • Restructuring Plagues Pledging System • Commencement Tradition to Change • Letters: Speak for Outside Graduation; Response to Tuition Increase • Swanson: No Chicken Fillet • Lewis to Present Black Perspective • Notes: Wismer Chimneys Smoked Out; Noon Aerobics Active Again; Chic Sharp Shooters Sought; Air Band Contest Announced • Men\u27s B-ball Win Brings Hopes for National Ranking • Match-Tough Matters Ready for Tourney • Gymnasts Take Bear Classic • Swimmers Stroke Victory in Season Opener • Bears Looking Hot in Winter Track • Chemistry Key for 1st Place Bears • Koffel\u27s Silver Anniversary Made Golden • Shikoda Not Far from Home • Europe Encounter Enraptures Jones • Rock \u27N Roll Forum • Robertson\u27s Release Rocks with Rhythmhttps://digitalcommons.ursinus.edu/grizzlynews/1202/thumbnail.jp

The Grizzly, April 10, 1987

Pfahler Hall Flooded • L.C.B. Visits a Second Time • Our Town Debuts • Letters: Director of Security at Sheraton Responds to Student Attack on Lorelei; Brothers of AXE Commended; Grizzly Dogged • Skunked Again • Students to Participate in Model UN Conference • Salamanca to Relate Experiences on Terrorism • Bard Graces Ursinus • Notes: UC / St. Joseph\u27s Host MBA Summer Session; Myrin Holds Semi-Annual Book Sale; New Resident Assistants Announced • Athlete of the Week: Kim Wentzel • Santangelo, O\u27Malley Jump Lady Bears to 6-0 Start • Women\u27s Tennis Served Tough Losses • Track\u27s Record: Record Breaking • Ursinus\u27 Champion Lacrosse Team: Vying for Fourth National Title • Opposition Unfavorable to Bears • Golf Team Drives Record to 8-0 • Softball Assumes First Place Position • Room Selection to Start • The Joshua Tree Rates an A • Young Democrats: Exhibiting New Challenges for the Future • Advanced TV Class Produces Ursinus Magazine For Cable Network • Arbor Day Trees Grow Money • Bear Facts: Ursinus Mascot Bearly Knownhttps://digitalcommons.ursinus.edu/grizzlynews/1187/thumbnail.jp

Epigenome-Wide Association Studies of the Fractional Exhaled Nitric Oxide and Bronchodilator Drug Response in Moderate-to-Severe Pediatric Asthma

Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR) and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA methylation (DNAm) contributes to asthma pathogenesis, the influence of DNAm on BDR and FeNO is scarcely investigated. This study aims to identify DNAm markers in whole blood associated either with BDR or FeNO in pediatric asthma. We analyzed 121 samples from children with moderate-to-severe asthma. The association of genome-wide DNAm with BDR and FeNO has been assessed using regression models, adjusting for age, sex, ancestry, and tissue heterogeneity. Cross-tissue validation was assessed in 50 nasal samples. Differentially methylated regions (DMRs) and enrichment in traits and biological pathways were assessed. A false discovery rate (FDR) < 0.1 and a genome-wide significance threshold of p < 9 × 10−8 were used to control for false-positive results. The CpG cg12835256 (PLA2G12A) was genome-wide associated with FeNO in blood samples (coefficient= −0.015, p = 2.53 × 10−9) and nominally associated in nasal samples (coefficient = −0.015, p = 0.045). Additionally, three CpGs were suggestively associated with BDR (FDR < 0.1). We identified 12 and four DMRs associated with FeNO and BDR (FDR < 0.05), respectively. An enrichment in allergic and inflammatory processes, smoking, and aging was observed. We reported novel associations of DNAm markers associated with BDR and FeNO enriched in asthma-related processes

Epigenome-Wide Association Studies of the Fractional Exhaled Nitric Oxide and Bronchodilator Drug Response in Moderate-to-Severe Pediatric Asthma

Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR) and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA methylation (DNAm) contributes to asthma pathogenesis, the influence of DNAm on BDR and FeNO is scarcely investigated. This study aims to identify DNAm markers in whole blood associated either with BDR or FeNO in pediatric asthma. We analyzed 121 samples from children with moderate-to-severe asthma. The association of genome-wide DNAm with BDR and FeNO has been assessed using regression models, adjusting for age, sex, ancestry, and tissue heterogeneity. Cross-tissue validation was assessed in 50 nasal samples. Differentially methylated regions (DMRs) and enrichment in traits and biological pathways were assessed. A false discovery rate (FDR) < 0.1 and a genome-wide significance threshold of p < 9 × 10−8 were used to control for false-positive results. The CpG cg12835256 (PLA2G12A) was genome-wide associated with FeNO in blood samples (coefficient= −0.015, p = 2.53 × 10−9) and nominally associated in nasal samples (coefficient = −0.015, p = 0.045). Additionally, three CpGs were suggestively associated with BDR (FDR < 0.1). We identified 12 and four DMRs associated with FeNO and BDR (FDR < 0.05), respectively. An enrichment in allergic and inflammatory processes, smoking, and aging was observed. We reported novel associations of DNAm markers associated with BDR and FeNO enriched in asthma-related processes