Longitudinal Insights into Student Behaviors and Program Impact: A Multi-Year Analysis of Post-Program Surveys Pre- and Post-COVID-19

Substance use is arguably the most pertinent concern for college students. The prolonged use of substances has consequences that may impact many aspects of one’s life. As a result of decades worth of research, multiple evidence-based interventions have been created to help aid college students. One of these interventions includes BASICS, Brief Alcohol Screening and Intervention for College Students. This study examined experiences of the BASICS program participants with special attention to the impact of COVID-19. It used a convenience sample of 44 after-program survey respondents from 2015 to 2022 at a faith-based private university in Texas. This study found no statistically significant difference in major outcomes before and after the onset of COVID-19. A consistent patten in the reduction of drinking after BASICS program across all time points implies that BASICS may be a promising practice model to address substance use problems of college students. Given the limitations of this study, it is recommended that practitioners improve the ways to monitor and evaluate the program

SNTP environmental, safety, and health

Viewgraphs on space nuclear thermal propulsion (SNTP) environmental, safety, and health are presented. Topics covered include: program safety policy; program safety policies; and DEIS public hearing comments

Effects of the Selective Protein Kinase C Inhibitor, Ro 31-7549, on the Proliferation of Cultured Mouse Epidermal Keratinocytes

We have investigated the effects of Ro 31-7549, a selective protein kinase C (PKC) inhibitor, on DNA synthesis and proliferation in two primary mouse epidermal keratinocyte culture systems. In differentiating keratinocytes incubated in medium containing 10% serum and high calcium (approximately 0.5 mM), Ro 31-7549 blocked the inhibitory effect of the phorbol ester 12-0-tetradecanoyl-13-acetate (TPA) (a PKC activator) on keratinocyte DNA synthesis at 24 h [50% maximal response concentration (EC50) = 1 μM], consistent with inhibition of PKC-mediated differentiation. Continuous treatment of the differentiative culture system with the PKC inhibitor resulted in a marked (fourfold) stimulation of [3H]thymidine incorporation at day 7 of exposure, with an EC50 of 0.25 μM. The potencies of these effects of Ro 31-7549 are comparable to that reported for inhibition of TPA-induced platelet 47-kD protein phosphorylation [50% inhibitory concentration (IC50) = 4.4 μM]. The time course of [3H]thymidine incorporation indicated that Ro 31-7549 did not directly stimulate DNA synthesis but instead prevented the loss of proliferative capacity associated with continued culture in this medium. Maximal stimulation (2.6 times) of DNA synthesis was observed on day 4, whereas DNA synthesis at day 1 was unaffected. In a highly proliferative culture system using serum-free medium containing 25 μM calcium, TPA dose-dependently inhibited proliferation with an IC50 of approximately 0.3 nM. This antiproliferative effect of TPA was largely reversed by 0.1 M Ro 31-7549. In the proliferative culture system, 0.75 M Ro 31-7549 also essentially reversed the inhibition of proliferation caused by switching to high (1.0 mM) calcium. These results suggest that the loss of proliferative capacity in differentiating epidermal keratinocyte cultures maybe mediated, at least in part, by PKC

Associations between national viral hepatitis policies/programmes and country-level socioeconomic factors: a sub-analysis of data from the 2013 WHO viral hepatitis policy report

BACKGROUND: As more countries worldwide develop national viral hepatitis strategies, it is important to ask whether context-specific factors affect their decision-making. This study aimed to determine whether country-level socioeconomic factors are associated with viral hepatitis programmes and policy responses across WHO Member States (MS). METHODS: WHO MS focal points completed a questionnaire on national viral hepatitis policies. This secondary analysis of data reported in the 2013 Global Policy Report on the Prevention and Control of Viral Hepatitis in WHO Member States used logistic regression to examine associations between four survey questions and four socioeconomic factors: country income level, Human Development Index (HDI), health expenditure and physician density. RESULTS: This analysis included 119 MS. MS were more likely to have routine viral hepatitis surveillance and to have a national strategy and/or policy/guidelines for preventing infection in healthcare settings if they were in the higher binary categories for income level, HDI, health expenditure and physician density. In multivariable analyses, the only significant finding was a positive association between having routine surveillance and being in the higher binary HDI category (adjusted odds ratio 26; 95% confidence interval 2.0-340). CONCLUSION: Countries with differing socioeconomic status indicators did not appear to differ greatly regarding the existence of key national policies and programmes. A more nuanced understanding of the multifaceted interactions of socioeconomic factors, health policy, service delivery and health outcomes is needed to support country-level efforts to eliminate viral hepatitis

Colorado Native Plant Society Newsletter, Vol. 3 No. 1, January-February 1979

The Colorado Native Plant Society Newsletter will be published on a bimonthly basis. The contents will consist primarily of a calendar of events, notes of interest, editorials, listings of new members and conservation news. Until there is a Society journal, the Newsletter will include short articles also. The deadline for the Newsletter is one month prior to its release.https://epublications.regis.edu/aquilegia/1012/thumbnail.jp

Striatal mGlu5-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways

Metabotropic glutamate receptor 5 (mGl

A major outburst from the X-ray binary RX J0520.5-6932

We report on the analysis of 8 years of MAssive Compact Halo Objects (MACHO) data for the source RX J0520.5-6932. A regular period of 24.4 days has been confirmed, however this is manifest almost entirely in the red part of the spectrum. A major outburst, lasting approximately 200 days, was observed which increased the apparent brightness of the object by approximately 0.15 magnitudes without significantly altering its V-R colour index. This outburst was also seen in X-ray data. The evidence from this analysis points to the identification of this object as a Be/X-ray binary with a periodically variable circumstellar disk and a very early optical counterpart.Comment: Paper has been accepted by MNRA