10 research outputs found
Morality, parenting and politics: How to talk about it
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<p>Harland, A.*, & Kurczek, J. (2013, April). Morality, parenting and politics: How to talk about it. <i>Poster presentation at the College of Social and Behavioral Sciences Student Research Conference</i>, Cedar Falls, IA.</p><p>• Metaphors are rich, powerful devices that can be used to easily convey complicated
messages.<br>
• Their use in political discourse serves as a way to potentially influence a person’s
agreeability with or understanding of complex subjects.
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<p>• However, while previous work has implicated that the use of metaphor by both dominant
political parties in the US, the metaphorical roots used by each party can be traced back to
two very distinct, conceptualizations of morality.<br>
• This begs the questions whether one system of metaphorical political discourse is more
effective than the other and whether that is modulated by a person’s own party.
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<p>• Moral views are major factors that influence political opinions. Every political stance can be
explained by one's moral position on the inner value of human beings and their role in
society. </p>
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The microRNA processor DROSHA is a candidate gene for a severe progressive neurological disorder
DROSHA encodes a ribonuclease that is a subunit of the Microprocessor complex and is involved in the first step of microRNA (miRNA) biogenesis. To date, DROSHA has not yet been associated with a Mendelian disease. Here, we describe two individuals with profound intellectual disability, epilepsy, white matter atrophy, microcephaly and dysmorphic features, who carry damaging de novo heterozygous variants in DROSHA. DROSHA is constrained for missense variants and moderately intolerant to loss-of-function (o/e = 0.24). The loss of the fruit fly ortholog drosha causes developmental arrest and death in third instar larvae, a severe reduction in brain size and loss of imaginal discs in the larva. Loss of drosha in eye clones causes small and rough eyes in adult flies. One of the identified DROSHA variants (p.Asp1219Gly) behaves as a strong loss-of-function allele in flies, while another variant (p.Arg1342Trp) is less damaging in our assays. In worms, a knock-in that mimics the p.Asp1219Gly variant at a worm equivalent residue causes loss of miRNA expression and heterochronicity, a phenotype characteristic of the loss of miRNA. Together, our data show that the DROSHA variants found in the individuals presented here are damaging based on functional studies in model organisms and likely underlie the severe phenotype involving the nervous system