PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients

Cervical cancer is the third largest cause of cancer mortality in India. The objectives of the study were to compare the pre and the post treatment quality of life in cervical cancer patients and to develop a prediction model to provide an insight into the possibilities in the treatment modules.status: publishe

Demographic and clinical characteristics of the patient cohort^*.

<p>*Values are means ± standard deviations.</p>†<p>FIGO, International Federation of Gynecology and Obstetrics.</p>‡<p>Some patients received multiple treatment interventions.</p

Mean Area Under Receiver Operating Characteristic (ROC) curve.

<p>Mean ROC (AUC) for Support Vector Machine algorithm with Linear Kernel for (A) Prediction of Symptom scale was 0.90. (B) Prediction of Global Health/QoL was 0.84. (C) Prediction of Functional scale was 0.85.</p

Coefficients(coef) of significant variables for Symptom scale, Functional scale and Global health/Quality of Life (GH/QoL) post treatment in Logistic Regression model, a Generalized linear model (GLM) type.

<p>Coefficients(coef) of significant variables for Symptom scale, Functional scale and Global health/Quality of Life (GH/QoL) post treatment in Logistic Regression model, a Generalized linear model (GLM) type.</p

The performance comparison of four machine learning algorithms on symptom, global health/QoL and functional scales for the prediction of post treatment cervical cancer quality of life outcomes.

<p>MSE = Mean Squared Error, AUC = Mean Area Under ROC(Receiver Operating Characteristics) Curve, AMI = Adjusted-for-chance Mutual Information Index, SVM(Linear) = Support Vector Machine with Linear Kernel, SVM(RBF) = Support Vector Machine with Radial Basis Function Kernel, LR = Logistic Regression, ANN = Artificial Neural Network.</p

EORTC QLQ CX-24 cervical cancer module scores in cervical cancer woman pre and post treatment.

<p>*P values are comparisons between groups with or student’s test.</p><p>Higher scores in the functioning and global health status scales represented better functioning and QOL, whereas higher scores in the symptom scales indicated greater problems.</p

Comparative pre and post treatment EORTC QLQ C-30 Quality of Life scores in cervical cancer women.

<p>*P values are comparisons between groups with or student’s test.</p><p>Higher scores in the functioning and global health status scales represented better functioning and QOL, whereas higher scores in the symptom scales indicated greater problems.</p

PrediQt-Cx: Post Treatment Health Related Quality of Life Prediction Model for Cervical Cancer Patients

<div><p>Background</p><p>Cervical cancer is the third largest cause of cancer mortality in India. The objectives of the study were to compare the pre and the post treatment quality of life in cervical cancer patients and to develop a prediction model to provide an insight into the possibilities in the treatment modules.</p><p>Methodology/Principal Findings</p><p>A total of 198 patients were assessed with two structured questionnaires of Health Related Quality of Life (The European Organisation for Research and Treatment of Cancer, EORTC QLQ C-30 and CX-24). The baseline observations were recorded when the patients first reported (T1) and second evaluation was done at 6 months post treatment (T2). The mean age of detection was 50.9 years with the literacy level being non-educated or less than high school. Majority of them were married/cohabiting 179 (90.4%). On histopathological examination (HPE) squamous cell carcinoma was found to be the most common cell type carcinoma 147 (74.2%) followed by Adenocarcinoma 31 (15.7%). Radical hysterectomy was the most common treatment modality 76 (38.4%), followed by Wertheims Hysterectomy 46 (23.2%) and Radiochemotherapy 59 (29.8%). The mean score of global health of cervical cancer patients post treatment was 77.90, which was significantly higher than the pre - treatment score (54.32). Mean “symptoms score” post treatment was 21.69 with an aggravation of 7.32 compared to pre treatment scores. Patients experienced substantial decrease in sexual activity post treatment.</p><p>Conclusions/Significance</p><p>The prediction model(PrediQt-Cx), based on Support Vector Machine(SVM) for predicting post treatment HRQoL in cervical cancer patients was developed and internally cross validated. After external validation PrediQt-Cx can be easily employed to support decision making by clinicians and patients from north India region, through openly made available for access at <a href="http://prediqt.org" target="_blank">http://prediqt.org</a>.</p></div