The pharmacologic effects of isoxsuprine

Isoxsuprine is a therapeutic medication used to treat navicular disease and other lower limb problems in horses and is one of the more frequently detected therapeutic agents in racing horses. In crossover studies, horses were administered intravenous and oral isoxsuprine to determine the character and duration of pharmacological effects. Following intravenous administration, isoxsuprine significantly increased heart rate, spontaneous activity, and sweat production. There was an apparent, although statistically insignificant, increase in cutaneous blood flow. Skin temperature decreased below control values, and there was a significant decrease in core temperature. Isoxsuprine also reduced smooth muscle tone. In contrast, after oral dosing, there was no statistical difference between control and isoxsuprine-treated horses for any of the measured variables. It was concluded that the measurable physiologic effects of intravenous isoxsuprine are short-lived, since none of the above responses was apparent four hours or more after intravenous administration

Warrantless Arrest Jurisdiction In Texas: An Analysis And A Proposal

Within the State of Texas, there exist a great number of “peace officers” who are granted a wide range of power and authority. This includes the power to make warrantless arrests and searches pursuant to those arrests. Significant ambiguity exists regarding a peace officer’s jurisdiction. The confusion is largely due to imprecise statutory language and varying judicial interpretations. Article 998 of Texas Revised Civil Statutes, for example, bestowed on city police officers the same powers, authority, and jurisdiction as city marshals. The statute, though, neglected to define the extent of that jurisdiction, or even what “jurisdiction” meant in that context. Article 999, which defined the duties and powers of city marshals, endowed city marshals with “like power, authority, and jurisdiction as the sheriff.” A cursory reading of these articles could lead to the understanding that a city police officer had countywide jurisdiction. In Angel v. State, the court considered the arrest jurisdiction of Tomball city police officers who observed a suspect operating what was later determined to be a stolen road paving machine outside the city limits of Tomball, but within Harris County. The Texas Court of Criminal Appeals concluded that the interweaving of loosely worded statutes, specifically articles 998 and 999, evidences the legislature’s intent to expand the common law jurisdiction of city police officers to the entire county. A city police officer’s territorial jurisdiction for arrest purposes is an issue unduly and unnecessarily complicated by the court’s tracing of ambiguous statutory provisions, and the potential for a similar result exists for other kinds of peace officers

Inclusive Education: Perceptions of Parents of Children with Special Needs of the Individual Program Planning Process

In inclusive education, students with special needs may access the curriculum through adapted or individualistic plans. Parental involvement in developing the individualistic plans is pertinent to the success of both their children’s education and the plan itself. Research from the United States offers insight into how parents perceive the process of developing individualist plans; however, limited research has been conducted with parents of children with special needs in Canada. This current study examines parental perceptions concerning the Individual Program Planning (IPP) process in Nova Scotia, Canada. Eight parents were interviewed using a guided interview format that consisted of 16 questions based on prior research on the subject matter. Qualitative analysis of the eight interviews resulted in the emergence of four key themes: a) Educator-Parent Communication, b) Parental Perception of Educational Climate, c) Parent Knowledge, and d) Improvements to the IPP process. Each category is reviewed here and supported with samples of direct quotations from parent interviewees. Recommendations are then suggested for educators and parents of children with special needs to promote positive and productive Individual Program Planning meetings

The Eerdmans Dictionary of Early Judaism

Angela Kim Harkins is a contributing author, Hymns, Prayers, and Psalms” pp. 753-757. Book description: This comprehensive and authoritative volume is the first reference work devoted exclusively to Second Temple Judaism. A striking and innovative project, it combines the best features of a survey and a reference work. The Eerdmans Dictionary of Early Judaism is ecumenical and international in character, bringing together the contributions of a superb group of Jewish, Christian, and other scholars.https://digitalcommons.fairfield.edu/religiousstudies-books/1014/thumbnail.jp

A novel NGS library preparation method to characterize native termini of fragmented DNA.

Biological and chemical DNA fragmentation generates DNA molecules with a variety of termini, including blunt ends and single-stranded overhangs. We have developed a Next Generation Sequencing (NGS) assay, XACTLY, to interrogate the termini of fragmented DNA, information traditionally lost in standard NGS library preparation methods. Here we describe the XACTLY method, showcase its sensitivity and specificity, and demonstrate its utility in in vitro experiments. The XACTLY assay is able to report relative abundances of all lengths and types (5' and 3') of single-stranded overhangs, if present, on each DNA fragment with an overall accuracy between 80-90%. In addition, XACTLY retains the sequence of each native DNA molecule after fragmentation and can capture the genomic landscape of cleavage events at single nucleotide resolution. The XACTLY assay can be applied as a novel research and discovery tool for fragmentation analyses and in cell-free DNA