Multi-gas Emissions Pathways to Meet Climate Targets

So far, climate change mitigation pathways focus mostly on CO2 and a limited number of climate targets. Comprehensive studies of emission implications have been hindered by the absence of a flexible method to generate multi-gas emissions pathways, user-definable in shape and the climate target. The presented method ‘Equal Quantile Walk' (EQW) is intended to fill this gap, building upon and complementing existing multi-gas emission scenarios. The EQW method generates new mitigation pathways by ‘walking along equal quantile paths' of the emission distributions derived from existing multi-gas IPCC baseline and stabilization scenarios. Considered emissions include those of CO2 and all other major radiative forcing agents (greenhouse gases, ozone precursors and sulphur aerosols). Sample EQW pathways are derived for stabilization at 350 ppm to 750 ppm CO2 concentrations and compared to WRE profiles. Furthermore, the ability of the method to analyze emission implications in a probabilistic multi-gas framework is demonstrated. The probability of overshooting a 2 ∘C climate target is derived by using different sets of EQW radiative forcing peaking pathways. If the probability shall not be increased above 30%, it seems necessary to peak CO2 equivalence concentrations around 475 ppm and return to lower levels after peaking (below 400 ppm). EQW emissions pathways can be applied in studies relating to Article 2 of the UNFCCC, for the analysis of climate impacts, adaptation and emission control implications associated with certain climate targets. See http://www.simcap.org for EQW-software and dat

Auf dem Weg nach Paris?

AUF DEM WEG NACH PARIS? Auf dem Weg nach Paris? / Fuentes Hutfilter, Ursula (Rights reserved) ( -

Indicate separate contributions of long-lived and short-lived greenhouse gases in emission targets

European Union funding: 821205, 821003, 820829. Wellcome Trust: 205212/Z/16/

Indicate separate contributions of long-lived and short-lived greenhouse gases in emission targets

European Union funding: 821205, 821003, 820829. Wellcome Trust: 205212/Z/16/

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP. SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors. A defining feature of XLP is exquisite sensitivity to infection with EBV, a B-lymphotropic virus, but not other viruses. Although previous studies have identified defects in lymphocytes from XLP patients, the unique role of SAP in controlling EBV infection remains unresolved. We describe a novel approach to this question using female XLP carriers who, due to random X-inactivation, contain both SAP+ and SAP− cells. This represents the human equivalent of a mixed bone marrow chimera in mice. While memory CD8+ T cells specific for CMV and influenza were distributed across SAP+ and SAP− populations, EBV-specific cells were exclusively SAP+. The preferential recruitment of SAP+ cells by EBV reflected the tropism of EBV for B cells, and the requirement for SAP expression in CD8+ T cells for them to respond to Ag-presentation by B cells, but not other cell types. The inability of SAP− clones to respond to Ag-presenting B cells was overcome by blocking the SLAM receptors NTB-A and 2B4, while ectopic expression of NTB-A on fibroblasts inhibited cytotoxicity of SAP− CD8+ T cells, thereby demonstrating that SLAM receptors acquire inhibitory function in the absence of SAP. The innovative XLP carrier model allowed us to unravel the mechanisms underlying the unique susceptibility of XLP patients to EBV infection in the absence of a relevant animal model. We found that this reflected the nature of the Ag-presenting cell, rather than EBV itself. Our data also identified a pathological signalling pathway that could be targeted to treat patients with severe EBV infection. This system may allow the study of other human diseases where heterozygous gene expression from random X-chromosome inactivation can be exploited

Squaring the circle of mitigation adequacy and equity : options and perspectives

The report surveys current proposals and positions on issues such as differentiated participation of countries in the new agreement, a differentiated spectrum of commitments, effort sharing and options for how to organise the negotiation process. The report finds that for the level of participation, the selection of commitment types, and choice of effort-sharing approaches there is no silver bullet. A portfolio approach that incorporates multiple options may be most suited to ensure environmental effectiveness, cost- effectiveness and political feasibility