Study on comprehensive policy review of anti-trafficking projects funded by the European Commission:HOME/2014/ISFP/PR/THBX/0052

This report addresses four objectives: 1. To conduct a comprehensive review of European Commission (EC) funded anti-trafficking projects so as to enhance coordination, avoid duplication and provide a solid basis for coherent, cost-effective and strategic planning, including potentially for the further development of anti-trafficking policies at EU level, thereby supporting the dual aims of enhanced coordination and cooperation among key actors and policy coherence. 2. To map and analyse the distribution of EC-funded anti-trafficking projects according to their scope of intervention, geographic areas of intervention, fields, actors, target beneficiaries, funding level, types of output, policy recommendations and other relevant aspects. 3. To identify and assess the common, unique or complementary contribution of the impact and results of these funded projects to the objectives of the EU anti-trafficking strategy, including whether their contribution has yet been taken into account. 4. To identify trends, emerging research and policy question

La mariée mise à nu par ses célibataires, même

OVERTIME was an exhibition that explored the differences between office spaces and the artists’ studio. SEIZE Leeds invited 26 artists to respond to an office space – to explore the tools and working methods common to such spaces through making art. Occupying a disused floor of Wellington Park House, in Leeds’ busy financial district, the exhibition brought together a diverse range of artists in order to showcase both emerging and more established practitioners from across the UK. SEIZE Leeds is an artist-led organisation that works to engage and support emerging and mid-career artists both regionally and nationally through a programme of ambitious art shows and events. They work with vacant spaces in situ to produce exciting and accessible exhibitions that explore ideas relevant to each location and promote talent

The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

Abstract The Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit in melanoma and lung cancer patients who progressed on immunotherapy. Here we show that modelling of intermittent ceralasertib treatment in mouse tumor models reveals CD8+ T-cell dependent antitumor activity, which is separate from the effects on tumor cells. Ceralasertib suppresses proliferating CD8+ T-cells on treatment which is rapidly reversed off-treatment. Ceralasertib causes up-regulation of type I interferon (IFNI) pathway in cancer patients and in tumor-bearing mice. IFNI is experimentally found to be a major mediator of antitumor activity of ceralasertib in combination with PD-L1 antibody. Improvement of T-cell function after ceralasertib treatment is linked to changes in myeloid cells in the tumor microenvironment. IFNI also promotes anti-proliferative effects of ceralasertib on tumor cells. Here, we report that broad immunomodulatory changes following intermittent ATR inhibition underpins the clinical therapeutic benefit and indicates its wider impact on antitumor immunity